Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells

Xu, Li Chong; Cuixia, Gao; Wu, Yupei; Cheng, C. Yan; Xia, Weiliang; Zhang, Zhiping

doi:10.1039/c4tb01764a

Cited by 56 publications

(39 citation statements)

References 37 publications

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“…Exploiting the specific affinity of HA for CD44 is thus an attractive strategy for targeted cancer treatments. Poly(lactic acid/glycolic acid) (PLGA), a FDA-approved biodegradable copolymer, can efficiently encapsulate hydrophobic drugs to form NPs, and thus has been widely used in drug delivery by our group and others [27, 34, 35]. To our knowledge, little effort has been made to develop HA-functionalized PLGA NPs for CPT and CUR co-delivery.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy

et al. 2015

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Nanoparticle (NP)-based combination chemotherapy has been proposed as an effective strategy for achieving synergistic effects and targeted drug delivery for colon cancer therapy. Here, we fabricated a series of hyaluronic acid (HA)-functionalized camptothecin (CPT)/curcumin (CUR)-loaded polymeric NPs (HA-CPT/CUR-NPs) with various weight ratios of CPT to CUR (1:1, 2:1 and 4:1). The resultant spherical HA-CPT/CUR-NPs had a desirable particle size (around 289 nm), relative narrow size distribution, and slightly negative zeta potential. These NPs exhibited a simultaneous sustained release profile for both drugs throughout the time frame examined. Subsequent cellular uptake experiments demonstrated that the introduction of HA to the NP surface endowed NPs with colon cancer-targeting capability and markedly increased cellular uptake efficiency compared with chitosan-coated NPs. Importantly, the combined delivery of CPT and CUR in one HA-functionalized NP exerted strong synergistic effects. HA-CPT/CUR-NP (1:1) showed the highest antitumor activity among the three HA-CPT/CUR-NPs, resulting in an extremely low combination index. Collectively, our findings indicate that this HA-CPT/CUR-NP can be exploited as an efficient formulation for colon cancer-targeted combination chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy

et al. 2015

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“…Among these, PLGA is a FDA-approved biodegradable copolymer that can encapsulate hydrophobic drugs to form NPs with high efficiency. Accordingly, it has been widely used in drug delivery [31, 32]. Unfortunately, the negative surface charge of PLGA NPs tends to impair their interaction with the cell surface, leading to low cellular internalization [33].…”

Section: Introductionmentioning

confidence: 99%

Co-delivery of camptothecin and curcumin by cationic polymeric nanoparticles for synergistic colon cancer combination chemotherapy

et al. 2015

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Nanoparticle (NP)-based combination chemotherapy has been proposed as a potent strategy for enhancing intracellular drug concentrations and achieving synergistic effects in colon cancer therapy. Here, we fabricated a series of chitosan-functionalized camptothecin (CPT)/curcumin (CUR)-loaded polymeric NPs with various weight ratios of CPT to CUR. The resultant cationic spherical CPT/CUR-NPs had a desirable particle size (193–224 nm), relatively narrow size distribution, and slightly positive zeta-potential. These NPs exhibited a simultaneous sustained release profile for both drugs throughout the study period with a slight, initial burst release. Subsequent cellular uptake experiments demonstrated that the introduction of chitosan to the NP surface markedly increased cellular-uptake efficiency compared with other drug formulations, and thus increased the intracellular drug concentrations. Importantly, the combined delivery of CPT and CUR in a single NP enhanced synergistic effects of the two drugs. Among the five cationic CPT/CUR-NPs tested, NPs with a CPT/CUR weight ratio of 4:1 showed the highest anticancer activity, resulting in a combination index of approximately 0.46. In summary, our study represents the first report of combinational application of CPT and CUR with a one-step–fabricated co-delivery system for effective colon cancer combination chemotherapy.

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“…Among the challenges associated to cancer treatment, it is the development of multidrug resistance (MDR), which negatively impacts the effect of chemotherapy drugs, and consequently treatment success. It was previously proposed that one of the viable solutions to overcome MDR is to combine two chemotherapeutic drugs, acting synergistically to target multiple key pathways to inhibit tumor progression [187,188]. In this context, the combination of β-elemene with other chemotherapeutic agents (i.e., cisplatin and doxorubicin) and other therapeutic adjuvant has demonstrated great potential to inhibit tumor cells and tumor growth.…”

Section: β-Elemenementioning

confidence: 99%

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

et al. 2020

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Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9-tetrahydrocannabinol (Δ9-THC)—as well as the G-protein-coupled cannabinoid receptors (CBR), named cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-2 (CB2R), both part of the now known endocannabinoid system (ECS). Cannabinoids is a vast term that defines several compounds that have been characterized in three categories: (i) endogenous, (ii) synthetic, and (iii) phytocannabinoids, and are able to modulate the CBR and ECS. Particularly, phytocannabinoids are natural terpenoids or phenolic compounds derived from Cannabis sativa. However, these terpenoids and phenolic compounds can also be derived from other plants (non-cannabinoids) and still induce cannabinoid-like properties. Cannabimimetic ligands, beyond the Cannabis plant, can act as CBR agonists or antagonists, or ECS enzyme inhibitors, besides being able of playing a role in immune-mediated inflammatory and infectious diseases, neuroinflammatory, neurological, and neurodegenerative diseases, as well as in cancer, and autoimmunity by itself. In this review, we summarize and critically highlight past, present, and future progress on the understanding of the role of cannabinoid-like molecules, mainly terpenes, as prospective therapeutics for different pathological conditions.

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Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells

Cited by 56 publications

References 37 publications

Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy

Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy

Co-delivery of camptothecin and curcumin by cationic polymeric nanoparticles for synergistic colon cancer combination chemotherapy

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

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