Combination Chemotherapy prior to Definitive Local Therapy in Squamous Cell Carcinoma of the Head and Neck

Dj, Adelstein; Jd, Hines; Vm, Sharan; Rr, Streeter; As, Earle; Cd, Haria; Sg, Carter; Ac, Shah; Vlastou, Catherine; Damm, C.

doi:10.1159/000226005

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…Despite repeated evaluation, since the 1970s, studies of induction chemotherapy have failed to demonstrate a significant LC or survival benefit. [7][8][9][10][11][12][13][14][15] In contradistinction, recent studies clearly demonstrate a survival benefit for concurrent chemoradiation therapy in comparison with RT alone. 16 -20 Many nonsurgical organ preservation protocols have also justified the use of induction chemotherapy to reduce distant metastases, in addition to selecting patients for nonsurgical therapy as described earlier, but this strategy may be of questionable benefit based on the results of RTOG 91-11, which indicate a reduced survivorship in patients experiencing initial local failure and no benefit from induction therapy.…”

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confidence: 99%

Survival Impact of Planned Restaging and Early Surgical Salvage Following Definitive Chemoradiation for Locally Advanced Squamous Cell Carcinomas of the Oropharynx and Hypopharynx

Yom

Machtay

Biel³

et al. 2005

American Journal of Clinical Oncology

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For patients with T3/4 resectable nonlaryngeal head and neck cancers, planned clinical, radiographic, and pathologic restaging at 1 to 2 months after definitive RT provides the opportunity for early surgical salvage in those who fail at the primary site. This practice produces improved overall local control and survival rates compared with the literature reports for delayed attempted salvage with timing based on the findings of routine postradiation clinical surveillance. Future efforts may focus on the improved selection of patients who would be most likely to require early surgical intervention.

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mentioning

confidence: 99%

Survival Impact of Planned Restaging and Early Surgical Salvage Following Definitive Chemoradiation for Locally Advanced Squamous Cell Carcinomas of the Oropharynx and Hypopharynx

Yom

Machtay

Biel³

et al. 2005

American Journal of Clinical Oncology

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“…cin, cisplatin regimen gives a high response rate; it has moderate toxicity and is easy to ad minister [10,11].…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated Carcinoma of the Sinuses and Cranial Basis Successfully Treated with Radiochemotherapy

Chandrasekaran

Baba²,

Othman³

et al. 1994

Chemotherapy

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Chemotherapy of Head and Neck Cancer

Kies

Levitan²,

Hong³

1988

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

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Single agent chemotherapy employing either hydroxyurea, cyclophosphamide, bleomycin, o r methotrexate has been reported to produce objective remissions in 30-40% of patients with advanced epidermoid carcinoma of the head and neck region. Responses are usually incomplete with remission durations of a few months. Methotrexate, the most extensively studied agent, appears to be most effective when used in a n intermittent (every 4-7 day) dosage schedule o r when used in high dosage followed by leucovorin "rescue." I n some reports, the intra-arterial administration of these drugs achieved better response rates, but the value of this approach is diminished by the high frequency of lesions that extend beyond the infused arterial supply and the high complication rate of catheterization procedures. Initial studies with dichlo-romethotrexate, a n equipotent analog of methotrexate which is hydroxylated to a n inactive form by the liver, suggest that intra-arterial use of this unique compound may be of value. Several studies indicate that the use of drugs in combination with radiotherapy may achieve greater tumor regression and longer response durations than radiotherapy alone; however, more controlled studies will be needed to establish this. T h e availability of effective agents with diverse mechanisms of action strongly suggests that major gains in chemotherapy of these tumors will be made in the next decade using combinations of drugs. PIDERMOID CARCINOMA OF T H E HEAD AND E neck region continues to be a therapeutic challenge to the surgeon, the radiotherapist , and the medical oncologist. Despite the fact that most of these lesions tend to remain local, and spread to a variable degree to regional nodes, cure rates for the advanced lesions, especially those with lymph node involvement , remain poor. Five-year survival rates's for these Stage 111 and IV lesions range from 3-34%, depending on the anatomic site, the histologic grade, and the presence or absence of nodal disease. Therefore, ideally each lesion should be carefully stagecIlSJ6 accord

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Combination Chemotherapy prior to Definitive Local Therapy in Squamous Cell Carcinoma of the Head and Neck

Cited by 8 publications

References 13 publications

Survival Impact of Planned Restaging and Early Surgical Salvage Following Definitive Chemoradiation for Locally Advanced Squamous Cell Carcinomas of the Oropharynx and Hypopharynx

Survival Impact of Planned Restaging and Early Surgical Salvage Following Definitive Chemoradiation for Locally Advanced Squamous Cell Carcinomas of the Oropharynx and Hypopharynx

Undifferentiated Carcinoma of the Sinuses and Cranial Basis Successfully Treated with Radiochemotherapy

Chemotherapy of Head and Neck Cancer

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