Combination chemotherapy for breast carcinoma using a combination of cyclophosphamide, methotrexate and 5‐fluorouracil (CMF) causes a platelet aggregation defect

Kumar, Anand; Chaturvedi, Pankaj; Gupta, Y. N.

doi:10.1002/(sici)1097-0215(19960410)66:2<159::aid-ijc3>3.3.co;2-3

Cited by 11 publications

(13 citation statements)

References 6 publications

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“…Especially, PVA owns the characteristics of ease of production, good biodegradability and mechanical properties, and high chemical stability, which make it a suitable candidate for biomedical applications. [ 28 ] Moreover, PVA‐based hydrogels can be prepared by physical method primarily generating the network by freeze‐thaw technique without the need for a toxic crosslinking agent, which are very beneficial for biomedical applications. [ 29 ]…”

Section: Introductionmentioning

confidence: 99%

Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds

Liu

et al. 2021

Macromolecular Bioscience

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In this work, a 3D printed double‐network (DN) hydrogel scaffold is designed with chitosan (CS) and polyvinyl alcohol (PVA) as the framework matrix. The addition of PVA into the CS‐based hydrogel clearly enhances the mechanical properties and lowers the swelling behaviors of the hydrogels. The crosslinking of CS with genipin can perform the pre‐crosslinking to improve the viscosity and 3D printability of the hydrogel precursor, while increasing the PVA content results in lowering the viscosity and 3D printability of the pre‐crosslinked hydrogel. The antibacterial property results of the DN hydrogel display that the hydrogel have favorable long‐lasting antibacterial ability. The appropriate pre‐crosslinked hydrogel with the CS/PVA mass ratio of 3:10 and pre‐crosslinking time of 7 h is used for 3D printing to prepare the 3D printed porous DN hydrogels. Moreover, the anti‐tumor drug doxorubicin (DOX) is loaded into the 3D printed porous DN hydrogels and the in vitro release study displays the sustainable drug release behavior. And the DOX release from hydrogel scaffold can be adjusted by the pH value of release environment. All of the results indicate that the porous DN CS/PVA hydrogel scaffolds have great application potential for tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds

Liu

et al. 2021

Macromolecular Bioscience

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“…[ 11,12 ] Second, their resemblance to biological tissues make them the most ideal materials for tissue engineering. [ 13 ] In cell culturing, the elastic modulus of hydrogel should be on the same order of magnitude as that of the cells to promote adhesion between cells and hydrogel, [ 14 ] and to better mimic physiological conditions. In stem cell studies, the modulus of hydrogels can also affect the differentiation, [ 15 ] proliferation, [ 16 ] mitigation, [ 17 ] and spreading [ 18 ] of stem cells.…”

mentioning

confidence: 99%

“…Poly(vinyl alcohol) (PVA) was used as a model system here, because of the simple molecular structure of the amphiphilic macromolecule composed of a hydrophobic (CH 2 CH 2 ) backbone and hydrophilic (OH) side‐groups. Besides, it has many other outstanding merits such as biodegradability, biocompatibility, and nontoxicity [ 13 ] which have been well studied and made as hydrogels with various methods, such as freeze‐thaw, chemically crosslinking, and mechanical training. [ 10,13 ] These make PVA an ideal exemplary polymer for the systematic study of the effects of various anions and cations on hydrogel networks, and to develop hydrogels with widely tunable mechanical, structural, and physical properties.…”

mentioning

confidence: 99%

“…Besides, it has many other outstanding merits such as biodegradability, biocompatibility, and nontoxicity [ 13 ] which have been well studied and made as hydrogels with various methods, such as freeze‐thaw, chemically crosslinking, and mechanical training. [ 10,13 ] These make PVA an ideal exemplary polymer for the systematic study of the effects of various anions and cations on hydrogel networks, and to develop hydrogels with widely tunable mechanical, structural, and physical properties. In this study, by gelation of PVA in various salt solutions, we have fabricated an ultratough hydrogel (strain 2100 ± 300%, stress 15 ± 1 MPa, toughness, 150 ± 20 MJ m −3 ) which has larger strain and stress than the most tough hydrogels reported previously and is even tougher than the synthetic polymers like PDMS, synthetic rubber, and natural spider silk.…”

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confidence: 99%

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Poly(vinyl alcohol) Hydrogels with Broad‐Range Tunable Mechanical Properties via the Hofmeister Effect

et al. 2021

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Hydrogels, exhibiting wide applications in soft robotics, tissue engineering, implantable electronics, etc., often require sophisticately tailoring of the hydrogel mechanical properties to meet specific demands. For examples, soft robotics necessitates tough hydrogels; stem cell culturing demands various tissue‐matching modulus; and neuron probes desire dynamically tunable modulus. Herein, a strategy to broadly alter the mechanical properties of hydrogels reversibly via tuning the aggregation states of the polymer chains by ions based on the Hofmeister effect is reported. An ultratough poly(vinyl alcohol) (PVA) hydrogel as an exemplary material (toughness 150 ± 20 MJ m−3), which surpasses synthetic polymers like poly(dimethylsiloxane), synthetic rubber, and natural spider silk is fabricated. With various ions, the hydrogel's various mechanical properties are continuously and reversibly in situ modulated over a large window: tensile strength from 50 ± 9 kPa to 15 ± 1 MPa, toughness from 0.0167 ± 0.003 to 150 ± 20 MJ m−3, elongation from 300 ± 100% to 2100 ± 300%, and modulus from 24 ± 2 to 2500 ± 140 kPa. Importantly, the ions serve as gelation triggers and property modulators only, not necessarily required to remain in the gel, maintaining the high biocompatibility of PVA without excess ions. This strategy, enabling high mechanical performance and broad dynamic tunability, presents a universal platform for broad applications from biomedicine to wearable electronics.

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“…Various parameters of coagulation are documented in the literature and have been shown to be clinically significant as regards the platelet function studies. 7 The platelet aggregation and PF 3 availability did not correlate with alterations in other coagulation parameters, such as platelet count, prothrombin time, clotting time and prothrombin consumption index.…”

Section: Discussionmentioning

confidence: 83%

5-Fluorouracil induces defects in platelet function

Kumar¹,

Kumar²,

Sandilium³

et al. 1999

CPLA

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Platelet factor-3 (PF(3)) availability and platelet aggregation to ADP (4 micromol/l) and adrenaline (1.2 micromol/l) were evaluated in patients being treated with 5-fluorouracil (5-FU) for gastrointestinal malignancy. It produced a significant reduction in platelet aggregation and platelet factor-3 (PF(3)) availability ( P < 0.001) without being associated with thrombocytopenia. The changes in platelet aggregation occurred during the first week of chemotherapy and continued with subsequent courses. This acquired abnormality may be responsible for a haemorrhagic diathesis even without obvious thrombocytopenia. Study of platelet function is important and may be considered to assess the haematological toxicity in patients being treated with systemic 5-FU therapy.

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Combination chemotherapy for breast carcinoma using a combination of cyclophosphamide, methotrexate and 5‐fluorouracil (CMF) causes a platelet aggregation defect

Cited by 11 publications

References 6 publications

Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds

Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds

Poly(vinyl alcohol) Hydrogels with Broad‐Range Tunable Mechanical Properties via the Hofmeister Effect

5-Fluorouracil induces defects in platelet function

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