Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months

Asiimwe‐Kateera, Brenda; Veldhuijzen, Nienke J.; Balinda, Jean Paul; Rusine, John; Eagle, Sally; Vyankandondera, Joseph; Mugabekazi, Julie; Ondoa, Pascale; Boer, Kimberly R.; Asiimwe, Anita; Lange, Joep M. A.; Reiss, Peter; Wijgert, Janneke van de

doi:10.1155/2015/740212

Cited by 2 publications

(2 citation statements)

References 21 publications

(28 reference statements)

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“…Two studies found no difference in pregnancy incidence by ART and one found higher pregnancy incidence among women not yet on ART than among those on ART , but these studies did not adjust for sociodemographic or health differences between the groups.…”

Section: Resultsmentioning

confidence: 98%

Impact of ART on the fertility of HIV‐positive women in sub‐Saharan Africa

Yeatman

Eaton

Beckles

et al. 2016

Tropical Med Int Health

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Objective: Understanding the fertility of HIV-positive women is critical to estimating HIV epidemic trends from surveillance data and planning resource needs and coverage of prevention-of-motherto-child transmission services in sub-Saharan Africa. In light of the considerable scale-up in antiretroviral therapy (ART) coverage over the last decade, we conducted a systematic review of the impact of ART on the fertility outcomes of HIV-positive women. Methods:We searched Medline, Embase, Popline, PubMed and African Index Medicus. Studies were included if they were conducted in sub-Saharan Africa and provided estimates of fertility outcomes (live births or pregnancies) among women on ART relative to a comparison group. Accepted Article Accepted ArticleThis article is protected by copyright. All rights reserved. Conclusions:Existing data are insufficient to characterize how ART has affected the fertility of HIVpositive women in sub-Saharan Africa. Improving evidence about fertility among women on ART is an urgent priority for planning HIV resource needs and understanding HIV epidemic trends. Alternative data sources such as antenatal clinic data, general population cohorts and population-based surveys can be harnessed to understand the issue.

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Section: Resultsmentioning

confidence: 98%

Impact of ART on the fertility of HIV‐positive women in sub‐Saharan Africa

Yeatman

Eaton

Beckles

et al. 2016

Tropical Med Int Health

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“…Patients with HIV infections are at risk of acute and chronic kidney diseases due to antiretroviral drugs and the balance of electrolytes and fluid can be altered leading to an imbalance of certain electrolytes and patients are at an increased risk of death 6 . This study was conducted to assess the kidney function and explore the association with electrolytes imbalance that can increase the risk of death in HIV patients under ART.…”

Section: Introductionmentioning

confidence: 99%

Association between kidney dysfunction and electrolytes imbalance among HIV patients attending Muhororo District Hospital

Fabrice,

Angelique,

Jean de Dieu

et al. 2024

J. Drug Delivery Ther.

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Background: Kidney diseases has been recognized as one of the challenging complications in HIV infected people. Hyponatremia and hyperkalemia are the most disturbed electrolytes associated with an increased risk of death both in hospitalized and in ambulatory HIV patients. Aim: The study aimed to assess the association between renal dysfunction and serum electrolytes disorders among HIV infected patients. Method: It was a retrospective study conducted at Muhororo district hospital from May up to July 2023. HIV infected patients were enrolled in the study and their serum creatinine, sodium, potassium and chloride were tested and the results analyzed by using SPSS version 22. A P-value less than 0.05 was considered statistically significance. Result: Among 115 HIV infected patients, 67.8% were females and 32.1% were males. The Mean serum creatinine was elevated among HIV infected patients [1.01(mg/dl) ±0.27, 0.99(mg/dl) ±0.26], and 40.8% had hyponatremia, 8% had hypernatremia, 6% had hypokalemia 7.8% had hyperkalemia 17.3% had hypochloremia and 20% had hyperchloremia Mean serum sodium was slightly decreased [134.1(mmol/l) ±11.8], there was no change in mean of both serum K+ and CL_ [4.4 (mmol/l) SD±1 / 100.7(mmol/l) with SD±14.2 for serum Cl-]. Serum creatinine was significantly associated with Na+ and K+ [P=0.04, r=-0.19/ p=0.01, r= 0.22] however the correlation between Cl- and Serum creatinine was not statistically significant [P=0.3, r=-0.08]. Conclusion: The study found elevated serum creatinine and, the weak correlation between creatinine and electrolytes in HIV infected patients on ART. The present findings need to be confirmed with further studies with large sample size. HIV infected patients should change life style that predispose their health to the development of kidney diseases they must also stick on healthcare provider’s counselling. Keywords: HIV, Kidney Dysfunction, Serum electrolytes.

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Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months

Cited by 2 publications

References 21 publications

Impact of ART on the fertility of HIV‐positive women in sub‐Saharan Africa

Impact of ART on the fertility of HIV‐positive women in sub‐Saharan Africa

Association between kidney dysfunction and electrolytes imbalance among HIV patients attending Muhororo District Hospital

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