Combination antioxidant effect of α-tocoferol and erdosteine in ischemia–reperfusion injury in rat model

Yurdakul, Talat; Kulaksızoğlu, Haluk; Pişkin, Mehmet Mesut; Avunduk, Mustafa Cihat; Ertemli, Esra; Gökçe, Gürhan; Barışkaner, Hülagü; Büyükbaş, Sadık; Kocabaş, Volkan

doi:10.1007/s11255-009-9641-y

Cited by 24 publications

(18 citation statements)

References 29 publications

(33 reference statements)

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“…In the literature, there is no agreement on antioxidant enzyme levels in various organs during the I/R state. However, some studies that measured activities of SOD showed reduced levels of these enzymes (31,33,34). SOD protects cells against the toxic effects of superoxide radicals by catalyzing their conversion to H 2 O 2 (30).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats

Sirmali¹,

Armağan²,

Öktem³

et al. 2015

Turk J Med Sci

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Background/aim: To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R).Materials and methods: Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined.Results: MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II (P < 0.01). Additionally, SOD, CAT, and GSH-Px activities were considerably (P < 0.05) decreased in group II. While CAT and GSH-Px activities were restored (P < 0.01) by vitamin E and C treatment, SOD activity was not significantly affected. While GSH-Px activities were higher (P < 0.05) with erdosteine administration, SOD and CAT activities were unchanged. Conclusion:The protective effect of vitamins C and E is higher than that of erdosteine treatment in reducing the oxidative stress after renal ischemia in this animal model.

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Section: Discussionmentioning

confidence: 99%

Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats

Sirmali¹,

Armağan²,

Öktem³

et al. 2015

Turk J Med Sci

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“…While the protective effect of vitamin E against AKI was first reported over 20 years ago, since then the therapeutic action of vitamin E has been demonstrated in many different animals (including mice [16,21], rats [13,22,23], rabbits [14], dogs [24], and pigs [25]) by using a variety of modeling methods (including ischemia/reperfusion [14,26,27], cisplatin [25,28], and other methods [13,29,30]), and has even been demonstrated in clinical studies [31,32] (Supplementary Table 1. Detailed information on the AKI models applied in the investigation of the protective effect of vitamin E).…”

Section: Therapeutic Action Of Vitamin E Against Akimentioning

confidence: 99%

Protective effect of vitamin E against acute kidney injury

Liu

Feng

Wang

et al. 2015

BME

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Abstract. It has been well-known for many years now that vitamin E is an essential nutrient; however, some of the physiological functions of this vitamin are still far from being understood. In recent years, a series of preclinical and clinical studies proposed a protective role of vitamin E on acute kidney injury (AKI), which has a high morbidity rate and mortality rate in clinical investigations. Based on the benefits associated with vitamin E, such as strong antioxidant function, low toxicity, rare side-effects, and low cost, this therapy strategy has garnered an extensive amount of interest in the scientific community for the development of new therapy modes against AKI. In this review, a concise overview of the application of vitamin E in the treatment of AKI is provided as well as a summary of a series of published data regarding the combination therapy modes and detailed therapy mechanisms of vitamin E-based therapy against AKI. At present, there are critical points of this therapy mode that are still in need of further clarification, meaning the current understanding of the role of vitamin E in the treatment of AKI remains incomplete. However, the development of more reliable pharmacological or biotechnical strategies with vitamin E for the eventual treatment of patients with AKI may guide the next chapter of vitamin E research.

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“…In another study, Yurdakul et al reported that levels of MDA and xanthine oxidase were decreased by erdosteine treatment (19). To our knowledge, this is the first study demonstrating the protective effect of erdosteine on I/R injury by erythrocyte deformability in an experimental lower limb I/R injury rat model.…”

Section: Discussionmentioning

confidence: 60%

Protective effect of erdosteine on erythrocyte deformabilityin a rat model of lower limb ischemia/reperfusion injury

Özer¹,

Demirtaş²,

Çomu³

et al. 2018

Turk J Med Sci

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Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteine on erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion. Materials and methods:Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized control group (group 'control' , n = 6), an ischemia/reperfusion group without erdosteine (group 'ischemia/reperfusion' , n = 6), and an ischemia/ reperfusion group with erdosteine at 150 mg kg -1 , intraperitoneally (group 'ischemia/reperfusion -erdosteine' , n = 6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were conducted.Results: Comparisons of the control and ischemia/reperfusion -erdosteine groups revealed similar results (P = 0.051). The values of the ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion -erdosteine groups (P < 0.0001 and P = 0.024, respectively). Relative resistance, a marker of erythrocyte deformability, was increased significantly by ischemia/ reperfusion compared to the control and ischemia/reperfusion -erdosteine groups (P < 0.05). Conclusion:We detected unfavorable effects of ischemia/reperfusion on erythrocyte deformability, which may lead to disturbance in blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that erdosteine had beneficial effects by reversing undesirable effects of ischemia/reperfusion. However, these promising results should be further supported by more detailed studies with larger volumes.

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Combination antioxidant effect of α-tocoferol and erdosteine in ischemia–reperfusion injury in rat model

Cited by 24 publications

References 29 publications

Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats

Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats

Protective effect of vitamin E against acute kidney injury

Protective effect of erdosteine on erythrocyte deformabilityin a rat model of lower limb ischemia/reperfusion injury

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