“…These include switching of antidepressants, combinations of antidepressants and augmentation of antidepressants with other medications. While switching of antidepressants has been associated with up to 50% response rates with the new antidepressant (Kennedy et al, 2001), no clear advantage has yet been shown in studies of antidepressant combinations and there is a potential risk of serious adverse events (Olver et al, 2007). Augmentation strategies have the advantage of avoiding delays due to changing of medications, retaining any partial gains achieved with the antidepressant and may be associated with rapid onset of effect.…”