Combination activity of neuraminidase inhibitor oseltamivir and α-tocopherol in influenza virus A (H3N2) infection in mice

Galabov, Angel S.; Mileva, Milka; Simeonova, Lora; Gegova, G

doi:10.1177/2040206616656263

Cited by 17 publications

(13 citation statements)

References 44 publications

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“…Moreover, in addition to its membrane protective effect in the influenza virus target area, vitamin E manifests pronounced activities as an antioxidant agent and as a protein kinase C inhibitor and a protector of lung tissue during inflammatory lung illnesses [59,80]. The study discussed above [76] convincingly demonstrates a strong beneficial effect of the combination of vitamin E and oseltamivir in the treatment of experimental infection with influenza virus A/H3N2 in mice.…”

Section: Vitamin E In the Influenza Therapymentioning

confidence: 85%

“…The in vivo antiviral activity of the combination vitamin E + oseltamivir, expressed by a marked protective effect on the survival of influenza A virus-infected animals, was recorded when vitamin E was administered simultaneously with oseltamivir phosphate via a 5-day course post virus inoculation [76]. This effect was not observed when the vitamin E course started 120 or 48 hours before viral inoculation.…”

Section: Vitamin E In the Influenza Therapymentioning

confidence: 99%

“…Recently, a strong beneficial effect of the combination of α-tocopherol (a component of vitamin E) and oseltamivir was demonstrated in the treatment of experimental infection with influenza virus A/H3N2 in mice [76]. The results showed that this combination of agents simultaneously suppressed the two main processes in the pathogenesis of influenza-the development of pulmonary lesions in the respiratory tract as a result of virus replication and the oxidative stress damage to membranes of small vessels and other tissues in the bodythus characterizing it as a very good prospect for flu therapy.…”

Section: Vitamin E In the Influenza Therapymentioning

confidence: 99%

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Vitamin E and Influenza Virus Infection

Mileva¹,

Galabov²

2018

Vitamin E in Health and Disease

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Influenza is an infectious disease causing huge medical and economic losses. Influenza pathogenesis is associated with two processes in the human body: (i) lung damage due to viral replication in the columnar ciliary epithelium of bronchi and bronchioles and (ii) inflammatory burst inducing an increase in reactive oxygen species generation that causes extensive damage in cellular membranes of the small vessels. The oxidative stress in influenza virus-infected organism provokes free-radical oxidation of unsaturated lipid chains in the cell membranes. As vitamin E is a lipid-soluble substance and possesses a hydrophobic tail, it tends to accumulate within lipid membranes. There, it acts as the most important chain breaker, reacting with lipid peroxyl radicals much faster than they can react with adjacent fatty acid side chains. Among the antioxidants tested in influenza virus infections in mice, vitamin E occupies the leading position because of its efficacy in preventing oxidative damage through its free-radical scavenging activity. Although vitamin E is not possessing specific antiviral action, its antioxidant effect probably plays important role in lung and liver protection. Attention should be paid to the synergistic character of antiviral effect of the combination vitamin E and oseltamivir. Vitamin E could be recommended as a component in multitarget influenza therapy.

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Section: Vitamin E In the Influenza Therapymentioning

confidence: 85%

Section: Vitamin E In the Influenza Therapymentioning

confidence: 99%

Section: Vitamin E In the Influenza Therapymentioning

confidence: 99%

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Vitamin E and Influenza Virus Infection

Mileva¹,

Galabov²

2018

Vitamin E in Health and Disease

Self Cite

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“…Among the antiviral strategies make use of anti-oxidants, alpha-tocopherol (Figure 19) enjoys a long history since 1960s (263)(264)(265)(266). Further researches revealed that alpha-tocopherol (or combination) could normalize the lipid peroxidation processes caused by viral infection (264,(267)(268)(269)(270)(271)(272).…”

Section: Anti-oxidantsmentioning

confidence: 99%

“…A classical combination is M2 blockers and NA inhibitors to avoid drug-resistance. Many studies have been carried out to evaluate the efficacy of combination therapies and single-drug treatment, and most combination therapies showed superior outcomes in mice models (272,(318)(319)(320)(321).…”

Section: Immunomodulatory Agentsmentioning

confidence: 99%

Progress of small molecular inhibitors in the development of anti-influenza virus agents

Wu¹,

Wu²,

Sun³

et al. 2017

Theranostics

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The influenza pandemic is a major threat to human health, and highly aggressive strains such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to combat these pathogens. Influenza anti-viral agents, especially active small molecular inhibitors play important roles in controlling pandemics while vaccines are developed. Currently, only a few drugs, which function as influenza neuraminidase (NA) inhibitors and M2 ion channel protein inhibitors, are approved in clinical. However, the acquired resistance against current anti-influenza drugs and the emerging mutations of influenza virus itself remain the major challenging unmet medical needs for influenza treatment. It is highly desirable to identify novel anti-influenza agents. This paper reviews the progress of small molecular inhibitors act as antiviral agents, which include hemagglutinin (HA) inhibitors, RNA-dependent RNA polymerase (RdRp) inhibitors, NA inhibitors and M2 ion channel protein inhibitors etc. Moreover, we also summarize new, recently reported potential targets and discuss strategies for the development of new anti-influenza virus drugs.

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Supplementation of α-Tocopherol Attenuates Minerals Disturbance, Oxidative Stress and Apoptosis Occurring in Favism

2016

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The favism is a metabolic disease that characterized with an acute hemolytic anemia where α-tocopherol is a type of tocopherol accumulated inside the human body. The objective of such a study was established to evaluate the effect of α-tocopherol in favism disorders. A total of 75 human cases were divided into 5 groups as follow; group 1 normal cases without any treatment and group 2 normal cases orally administrated α-tocopherol (200 mg/kg) once a day over 30 days period. Group 3 favism patients without any treatment. Groups 4 and 5 favism patients orally administrated 100 and 200 mg α-tocopherol/kg, respectively once a day over 30 days period. The results obtained revealed that oral administration of α-tocopherol into normal cases over 30 days period did not induce any biological change. In favism, hemoglobin, hematocrit, red and white blood cells, serum glucose, glucose-6-phosphate dehydrogenase, total protein, albumin, globulin, aspartate and alanine aminotransferases, blood glutathione, superoxide dismutase, glutathione peroxidase and serum calcium, phosphorous, sodium, potassium and chloride levels were significantly decreased. On the other hand, serum alkaline phosphatase, bilirubin, selenium, zinc, manganese, copper and iron, malondialdehyde levels showed significant increase in favism. Supplementation with α-tocopherol into favism restores all the above mentioned parameters to approach the normal levels. Also, α-tocopherol has anti-apoptotic effect in favism. In conclusion, α-tocopherol attenuates minerals disturbance, oxidative stress and apoptosis occurring in favism.

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Combination activity of neuraminidase inhibitor oseltamivir and α-tocopherol in influenza virus A (H3N2) infection in mice

Abstract: Evidently, α-tocopherol could be considered as prospective component of influenza therapy in combination with oseltamivir.

Cited by 17 publications

References 44 publications

Vitamin E and Influenza Virus Infection

Vitamin E and Influenza Virus Infection

Progress of small molecular inhibitors in the development of anti-influenza virus agents

Supplementation of α-Tocopherol Attenuates Minerals Disturbance, Oxidative Stress and Apoptosis Occurring in Favism

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