Combinação de anlodipino e enalaprila em pacientes hipertensos com doença coronariana

Rienzo, Marcos; Saraiva, José Francisco Kerr; Nogueira, Paulo Roberto; Gomes, Everli Pinheiro de Souza Gonçalves; Moretti, Miguel Antônio; Ferreira, João Fernando Monteiro; Armagnajian, Dikran; Mansur, Antônio de Pádua; Ramires, José Antônio Franchini; César, Luiz Antonio Machado

doi:10.1590/s0066-782x2009000300004

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…The participants in both groups had the same clinical profiles, had chronic coronary arterial disease, and had been followed as outpatients at the institution. Some of these trials were published with all patients here enrolled ( 13 , 14 ) and other were part of the casuistic of the final trial ( 15 ).…”

Section: Methodsmentioning

confidence: 99%

Motivation and frustration in cardiology trial participation: The patient perspective

Meneguin¹,

Cesar²

2012

Clinics

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OBJECTIVE:The participation of humans in clinical cardiology trials remains essential, but little is known regarding participant perceptions of such studies. We examined the factors that motivated participation in such studies, as well as those that led to participant frustration.METHODS:Patients who had participated in hypertension and coronary arterial disease (phases II, III, and IV) clinical trials were invited to answer a questionnaire. They were divided into two groups: Group I, which included participants in placebo-controlled clinical trials after randomization, and Group II, which included participants in clinical trials in which the tested treatment was compared to another drug after randomization and in which a placebo was used in the washout period.RESULTS:Eighty patients (47 patients in Group I and 33 patients in Group II) with different socio-demographic characteristics were interviewed. Approximately 60% of the patients were motivated to participate in the trial with the expectation of personal benefit. Nine participants (11.2%) expressed the desire to withdraw, which was due to their perception of risk during the testing in the clinical trial (Group I) and to the necessity of repeated returns to the institution (Group II). However, the patients did not withdraw due to fear of termination of hospital treatment.CONCLUSIONS:Although this study had a small patient sample, the possibility of receiving a benefit from the new tested treatment was consistently reported as a motivation to participate in the trials.

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Section: Methodsmentioning

confidence: 99%

Motivation and frustration in cardiology trial participation: The patient perspective

Meneguin¹,

Cesar²

2012

Clinics

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Original research articles on the cardiopulmonary system recently appeared in Brazilian clinical and surgical journals

Patel¹,

Caramelli²,

Silva³

2011

Revista da Associação Médica Brasileira

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Original research articles on the cardiopulmonary system recently appeared in Brazilian clinical and surgical journals

Patel¹,

Caramelli

Silva

2011

Revista da Associação Médica Brasileira (English Edition)

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Combinação de anlodipino e enalaprila em pacientes hipertensos com doença coronariana

Abstract: SummaryBackground: Patients (pts) with stable coronary artery disease (CAD) can benefit from a decrease in the blood pressure (BP), according to recent studies.

Cited by 8 publications

References 22 publications

Motivation and frustration in cardiology trial participation: The patient perspective

Motivation and frustration in cardiology trial participation: The patient perspective

Original research articles on the cardiopulmonary system recently appeared in Brazilian clinical and surgical journals

Original research articles on the cardiopulmonary system recently appeared in Brazilian clinical and surgical journals

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