Combgap Relays Wingless Signal Reception to the Determination of Cortical Cell Fate in the Drosophila Visual System

Song, Yohan; Chung, Soohee; Kunes, Sam

doi:10.1016/s1097-2765(00)00112-x

Cited by 21 publications

(33 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As described above, Ds is expressed in a gradient that decreases with distance from the Wg domains (Song et al, 2000) (Fig. 4D,E).…”

Section: The Role Of Scaffold Axons In Glial Migrationsupporting

confidence: 58%

“…The Wingless expressing cells of the dorsal and ventral domains are located in areas of complex gene expression controlled by Wingless (Wg) signaling activity (Fig. 4A) (Kaphingst and Kunes, 1994;Song et al, 2000). Adjacent to the Wg domains are non-overlapping cell populations that express the TGF-β family member Decapentaplegic (Dpp; Fig.…”

Section: Clonal Analysis Defines the Origins Of Glia And The Neurons mentioning

confidence: 99%

“…Both the Wg-and Dpppositive cell populations express the transcription factor Optomotor Blind (Omb; Fig. 4D) (Poeck et al, 1993;Huang and Kunes, 1998;Song et al, 2000). Dachsous (Ds), a Cadherin family member (Clark et al, 1995), is expressed a graded fashion with respect to the Wg domains (Fig.…”

Section: Clonal Analysis Defines the Origins Of Glia And The Neurons mentioning

confidence: 99%

“…Dachsous (Ds), a Cadherin family member (Clark et al, 1995), is expressed a graded fashion with respect to the Wg domains (Fig. 4D,E) (Song et al, 2000). These three genes, though expressed in different patterns, are under the control of Wg activity (Song et al, 2000).…”

Section: Clonal Analysis Defines the Origins Of Glia And The Neurons mentioning

confidence: 99%

“…4D,E) (Song et al, 2000). These three genes, though expressed in different patterns, are under the control of Wg activity (Song et al, 2000).…”

Section: Clonal Analysis Defines the Origins Of Glia And The Neurons mentioning

confidence: 99%

See 4 more Smart Citations

An axon scaffold induced by retinal axons directs glia to destinations in theDrosophilaoptic lobe

Dearborn

Kunes

2004

Development

Self Cite

View full text Add to dashboard Cite

In the developing Drosophila visual system, glia migrate into stereotyped positions within the photoreceptor axon target fields and provide positional information for photoreceptor axon guidance. Glial migration conversely depends on photoreceptor axons, as glia precursors stall in their progenitor zones when retinal innervation is eliminated. Our results support the view that this requirement for retinal innervation reflects a role of photoreceptor axons in the establishment of an axonal scaffold that guides glial cell migration. Optic lobe cortical axons extend from dorsal and ventral positions towards incoming photoreceptor axons and establish at least four separate pathways that direct glia to proper destinations in the optic lobe neuropiles. Photoreceptor axons induce the outgrowth of these scaffold axons. Most glia do not migrate when the scaffold axons are missing. Moreover, glia follow the aberrant pathways of scaffold axons that project aberrantly, as occurs in the mutant dachsous. The local absence of glia is accompanied by extensive apoptosis of optic lobe cortical neurons. These observations reveal a mechanism for coordinating photoreceptor axon arrival in the brain with the distribution of glia to multiple target destinations, where they are required for axon guidance and neuronal survival.

show abstract

“…As described above, Ds is expressed in a gradient that decreases with distance from the Wg domains (Song et al, 2000) (Fig. 4D,E).…”

Section: The Role Of Scaffold Axons In Glial Migrationsupporting

confidence: 58%

Section: Clonal Analysis Defines the Origins Of Glia And The Neurons mentioning

confidence: 99%

Section: Clonal Analysis Defines the Origins Of Glia And The Neurons mentioning

confidence: 99%

Section: Clonal Analysis Defines the Origins Of Glia And The Neurons mentioning

confidence: 99%

“…4D,E) (Song et al, 2000). These three genes, though expressed in different patterns, are under the control of Wg activity (Song et al, 2000).…”

Section: Clonal Analysis Defines the Origins Of Glia And The Neurons mentioning

confidence: 99%

See 3 more Smart Citations

An axon scaffold induced by retinal axons directs glia to destinations in theDrosophilaoptic lobe

Dearborn

Kunes

2004

Development

Self Cite

View full text Add to dashboard Cite

show abstract

Misexpression screen for genes altering the olfactory map in Drosophila

Zhang

Zhou

Yin

et al. 2006

Genesis

View full text Add to dashboard Cite

Despite the identification of a number of guidance molecules, a comprehensive picture has yet to emerge to explain the precise anatomy of the olfactory map. From a misexpression screen of 1,515 P{GS} lines, we identified 23 genes that, when forcibly expressed in the olfactory receptor neurons, disrupted the stereotyped anatomy of the Drosophila antennal lobes. These genes, which have not been shown previously to control olfactory map development, encode novel proteins as well as proteins with known roles in axonal outgrowth and cytoskeletal remodeling. We analyzed Akap200, which encodes a Protein Kinase A-binding protein. Overexpression of Akap200 resulted in fusion of the glomeruli, while its loss resulted in misshapen and ectopic glomeruli. The requirement of Akap200 validates our screen as an effective approach for recovering genes controlling glomerular map patterning. Our finding of diverse classes of genes reveals the complexity of the mechanisms that underlie olfactory map development.

show abstract

Axin: An emerging key scaffold at the synapse

Chen

2013

IUBMB Life

View full text Add to dashboard Cite

Neurons communicate through neurotransmission at the synapse. Precise regulation of the synaptic structure and signaling during the formation and remodeling of synapses is vital for information processing between neurons. Scaffold proteins play key roles in synapses by tethering the signaling cascades spatially and temporally to ensure proper brain functioning.This review summarizes the recent evidence indicating that Axin, a scaffold protein, plays a central role in orchestrating presynaptic and postsynaptic signaling complexes to regulate synapse development and plasticity in the central nervous system. V C 2013 IUBMB Life, 65(8):685-691, 2013.

show abstract

Combgap Relays Wingless Signal Reception to the Determination of Cortical Cell Fate in the Drosophila Visual System

Cited by 21 publications

References 75 publications

An axon scaffold induced by retinal axons directs glia to destinations in theDrosophilaoptic lobe

An axon scaffold induced by retinal axons directs glia to destinations in theDrosophilaoptic lobe

Misexpression screen for genes altering the olfactory map in Drosophila

Axin: An emerging key scaffold at the synapse

Contact Info

Product

Resources

About