Combating Infectious Diseases with Synthetic Biology

Abstract

Over the past decades, there have been numerous outbreaks, including parasitic, fungal, bacterial, and viral infections, worldwide. The rate at which infectious diseases are emerging is disproportionate to the rate of development for new strategies that could combat them. Therefore, there is an increasing demand to develop novel, specific, sensitive, and effective methods for infectious disease diagnosis and treatment. Designed synthetic systems and devices are becoming powerful tools to treat human diseases. The advancement in synthetic biology offers efficient, accurate, and cost-effective platforms for detecting and preventing infectious diseases. Herein we focus on the latest state of living theranostics and its implications.

BioNexusSentinel: a visual tool for bioregulatory network and cytohistological RNA-seq genetic expression profiling within the context of multicellular simulation research using ChatGPT-augmented software engineering

“…Designing living therapeutics is another prospect, e.g. immune T-Cell therapies ( BBC_News 2022 ) or to counteract infectious diseases using commensal bacteria ( Khan et al 2022 ), especially with a multicellular histological simulation component related to our ongoing and past ( Matzko et al 2023 ) research. From the perspective of the Z-score based methods in GEP and the R statistics for the cell lineage classifier using Manhattan distance of feature vectors, diagnostics and therapeutics might be tailored regarding the healthy range of expression norms, or indeed cell lineage classification.…”

Phage therapy: breathing new tactics into lower respiratory tract infection treatments

“…Engineered phages, designed to target specific pathogens, have demonstrated potential as a therapeutic option for treating infections that occur after lung transplant in patients with CF [ 82 ]. After undergoing a lung transplant, a patient with CF, who had a medical history of infections caused by P. aeruginosa and Mycobacterium abscessus received phage therapy; The treatment involved the i.v.…”