Combating cancer by utilizing noble metallic nanostructures in combination with laser photothermal and X-ray radiotherapy

Kayani, Zahra; Islami, Negar; Behzadpour, Niloufar; Zahraie, N.; Imanlou, Sanaz; Tamaddon, Paria; Salehi, Fatemeh; Daneshvar, Fatemeh; Perota, Ghazale; Sorati, Elmira; Mohammadi, Sahar; Sattarahmady, N.

doi:10.1016/j.jddst.2021.102689

Cited by 10 publications

(9 citation statements)

References 122 publications

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“…161,162 As an effective X-PDT "anti-cancer weapon", metal nanoparticles or nanoclusters containing high z-elements and rich d states are the best choices. [163][164][165] Due to the high atomic number Z and a rich free electron, heavy metal cluster complexes have a good luminescence efficiency. [166][167][168][169] They can increase the damage of radiation on tumor cells.…”

Section: Metal-based Materialsmentioning

confidence: 99%

Catalytic nanotechnology of X-ray photodynamics for cancer treatments

Zhang

Guo

et al. 2023

Biomater. Sci.

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Section: Metal-based Materialsmentioning

confidence: 99%

Catalytic nanotechnology of X-ray photodynamics for cancer treatments

Zhang

Guo

et al. 2023

Biomater. Sci.

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“…Photo-thermal therapy (PTT) requires 700–1100 nm of the near-infrared (NIR) wavelength using a laser in combination with therapeutic agents capable of absorbing the incoming wavelength and propagating it to tissues and local tumor cells in the form of heat [ 85 ].…”

Section: In Vitro and In Vivo Applications Of Aunps For Cancer Therapiesmentioning

confidence: 99%

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

et al. 2023

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The conventional methods of cancer treatment and diagnosis, such as radiotherapy, chemotherapy, and computed tomography, have developed a great deal. However, the effectiveness of such methods is limited to the possible failure or collateral effects on the patients. In recent years, nanoscale materials have been studied in the field of medical physics to develop increasingly efficient methods to treat diseases. Gold nanoparticles (AuNPs), thanks to their unique physicochemical and optical properties, were introduced to medicine to promote highly effective treatments. Several studies have confirmed the advantages of AuNPs such as their biocompatibility and the possibility to tune their shapes and sizes or modify their surfaces using different chemical compounds. In this review, the main properties of AuNPs are analyzed, with particular focus on star-shaped AuNPs. In addition, the main methods of tumor treatment and diagnosis involving AuNPs are reviewed.

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“…However, tumor hypoxia is the main obstacle in RT applications at low linear-energy transfer, typical for many photon/electron beams, because the O 2 concentration controls the DNA damage by reactive oxygen species. Nevertheless, recent reports [264,265] showed promising capabilities of integrated RT and PPT technologies.…”

Section: Combining Ppt With Other Therapies To Achieve Synergic Effic...mentioning

confidence: 99%

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Bucharskaya

Khlebtsov

et al. 2022

Materials

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Cancer remains one of the leading causes of death in the world. For a number of neoplasms, the efficiency of conventional chemo- and radiation therapies is insufficient because of drug resistance and marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored in tumor treatment. However, despite attractive promises, the current PPT status is limited by laboratory experiments, academic papers, and only a few preclinical studies. Unfortunately, most nanoformulations still share a similar fate: great laboratory promises and fair preclinical trials. This review discusses the current challenges and prospects of plasmonic nanomedicine based on PPT and photodynamic therapy (PDT). We start with consideration of the fundamental principles underlying plasmonic properties of AuNPs to tune their plasmon resonance for the desired NIR-I, NIR-2, and SWIR optical windows. The basic principles for simulation of optical cross-sections and plasmonic heating under CW and pulsed irradiation are discussed. Then, we consider the state-of-the-art methods for wet chemical synthesis of the most popular PPPT AuNPs such as silica/gold nanoshells, Au nanostars, nanorods, and nanocages. The photothermal efficiencies of these nanoparticles are compared, and their applications to current nanomedicine are shortly discussed. In a separate section, we discuss the fabrication of gold and other nanoparticles by the pulsed laser ablation in liquid method. The second part of the review is devoted to our recent experimental results on laser-activated interaction of AuNPs with tumor and healthy tissues and current achievements of other research groups in this application area. The unresolved issues of PPT are the significant accumulation of AuNPs in the organs of the mononuclear phagocyte system, causing potential toxic effects of nanoparticles, and the possibility of tumor recurrence due to the presence of survived tumor cells. The prospective ways of solving these problems are discussed, including developing combined antitumor therapy based on combined PPT and PDT. In the conclusion section, we summarize the most urgent needs of current PPT-based nanomedicine.

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Combating cancer by utilizing noble metallic nanostructures in combination with laser photothermal and X-ray radiotherapy

Cited by 10 publications

References 122 publications

Catalytic nanotechnology of X-ray photodynamics for cancer treatments

Catalytic nanotechnology of X-ray photodynamics for cancer treatments

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

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