Colposcopic biopsy findings among women with either <scp>HPV</scp>‐16 only or <scp>HPV</scp>‐18 only who have normal cervical cytology

Yalçın, İbrahim; Sarı, Mustafa; Şahin, Hanifi; Gültekin, Murat; Güngör, Tayfun; Meydanlı, Mehmet Mutlu

doi:10.1002/ijgo.12652

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Interestingly, Çöl Madendağ et al (11) reported that the detected CIN 2+ lesions with normal cytology were higher in cases of non-16/18 HPV subtypes, contrary to 16/18 HPV subtypes. Yalcin et al (12) stated that the colposcopic evaluation of the normal cytologic results of the HPV 16 cases did not increase the detection rate of cervical cancer. Conflicting results are reported in the literature in cases of negative cytology results with positive non-16/18 HPV subtypes.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Colposcopic Biopsy Results of Non-HPV 16/18 Oncogenic Type Positive Patients

Vural¹,

Karadeniz²,

Karadeniz³

et al. 2021

csmedj

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Objective: This study aimed to evaluate and compare the risk in detecting cervical intraepithelial neoplasia (CIN) 2+ or higher lesions by performing immediate colposcopy in patients with positive high-risk non-human papillomavirus (HPV) 16/18 subtypes, regardless of their cytology results. Material and Methods:A total of 264 patients with HPV-positive subtypes, aged 20-65 years, with any type of cervical cytology results were included in the study. A liquid-based cytologic cervical cancer screening with HPV testing was carried out between November 2020 and May 2021. Cytological specimens were classified according to the Bethesda system (2014), and HPV identification was analyzed with Cobas 4800 system. Colposcopy-guided endocervical curettage and endometrial biopsy were performed.Results: A total of 123 patients had HPV non-16/18 oncogenic types, wherein 34 (69.3%) had no dysplasia, 9 (18.3%) had CIN 1, and 2 (4.08%) had CIN 2-3. Conclusion:Colposcopic evaluation may be considered in cases of non-16/18 high-risk HPV subtypes with abnormal cytologic results. Among the patients who had negative cervical cytology and positive non-HPV-16/18, 4.08% were women with CIN 2-3. Following the algorithm according to the guidelines, there will be a risk of 4.08% of misdiagnosing CIN 2+ lesions by gynecologists. Organizing large-scale randomized controlled studies will help in understanding the meaning or importance of this topic.

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Section: Discussionmentioning

confidence: 99%

Comparison of Colposcopic Biopsy Results of Non-HPV 16/18 Oncogenic Type Positive Patients

Vural¹,

Karadeniz²,

Karadeniz³

et al. 2021

csmedj

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“…El diagnóstico histológico es la prueba confirmatoria para la citología cervicouterina, mientras que la colposcopia es el complemento esencial entre ambos estudios, porque permite el examen clínico y morfológico que orienta las biopsias para la histología (92).…”

Section: Histología Y Colposcopíaunclassified

Virus Papiloma Humano. Un enemigo silencioso en el Ecuador y el mundo

Carrión Ordóñez,

Bravo Salinas,

Escandón Carrión

et al. 2024

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“…[9][10][11][12] The initiatives to implement molecular tests in population screening are justified because there is evidence that the presence of hrHPV infection, even among women with normal cytology, increases the risk of CIN2þ and may contribute to bringing the diagnosis forward by more than a decade depending on the case. [11][12][13][14][15] In addition, HPV16/18 coinfection is related to high rates of high-grade lesions (56.7%) and cancer (71.1%), 16 which demonstrates the importance of tests based on the polymerase chain reaction (PCR) technique with genotyping of the viral types.…”

Section: Introductionmentioning

confidence: 99%

Risk Profile of High-grade Cervical Lesions and Cervical Cancer Considering the Combination of Cytology, HPV Genotype, and Age among Women Undergoing Colposcopy

Possati-Resende,

Fritsch,

Souza

2023

Rev Bras Ginecol Obstet

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Objective The present study aims to establish a risk profile for high-grade cervical lesions and cervical cancer (CIN2 + ) in women undergoing colposcopy at the Hospital do Câncer de Barretos, through the analysis of Human Papillomavirus (HPV) infection, cervical cytology, and patient's age. Methods Retrospective cross-sectional study based on a computerized database of women aged ≥ 18 years old who underwent colposcopy at the Prevention Department of the Hospital do Câncer de Barretos from 2017 to 2019. Results A total of 3,411 women were included, 58.0% were positive for high-risk-HPV test, with a higher prevalence of CIN2+ for HPV16 (30.3%) and other HPV (45.0%). Cytological findings that suggest invasive cervical cancer (squamous cells or adenocarcinoma), regardless of the status of HPV test, showed 100% diagnosis of CIN2 + , while atypias that suggest high-grade lesions, HSIL and ASC-H, positive for HPV test, showed in 86 and 55.2%, respectively, diagnosis of CIN2 + . ASC-H cytological results among women aged > 40 years old and negative HPV were mainly associated with benign findings. We observed that ≤ CIN1 has a higher prevalence among older women with negative HPV, while for high-grade lesions there is an increase among young women HPV16- and/or 18-positive. In cancer diagnosis, we observed a predominance of HPV 16/18 regardless of the age group. Conclusion The highest risks of precursor lesions and cervical cancer were found among women with positive HPV 16/18 tests and severe cytological atypia in population screening tests. In addition, cytological findings of ASC-H HPV negative in women > 40 years old usually represent benign findings in histological investigation.

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Colposcopic biopsy findings among women with either HPV‐16 only or HPV‐18 only who have normal cervical cytology

Abstract: Although the risk of high-grade squamous intraepithelial lesions was increased among women with HPV-16 only, this finding did not influence the rate of invasive cervical cancer when compared with women in the HPV-18 only group.

Cited by 4 publications

References 23 publications

Comparison of Colposcopic Biopsy Results of Non-HPV 16/18 Oncogenic Type Positive Patients

Comparison of Colposcopic Biopsy Results of Non-HPV 16/18 Oncogenic Type Positive Patients

Virus Papiloma Humano. Un enemigo silencioso en el Ecuador y el mundo

Risk Profile of High-grade Cervical Lesions and Cervical Cancer Considering the Combination of Cytology, HPV Genotype, and Age among Women Undergoing Colposcopy

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