Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine

Alarcon, Emilio I.; Vulesevic, Branka; Argawal, A; Ross, Alex; Bejjani, P; Podrebarac, James; Ranjithkumar, R.; Phopase, Jaywant; Suuronen, Erik J.; Griffith, May

doi:10.1039/c6nr01339b

Cited by 77 publications

(55 citation statements)

References 51 publications

(77 reference statements)

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“…While a dose-dependent cellular toxicity caused by AgNPs and Ag + in A549 human lung-derived cells, the cytotoxicity of both silver compounds significantly decreased following pre-treatment with the antioxidant N -acetyl-cysteine [ 111 ]. For safe fabrication and incorporation of different shapes of AgNPs in collagen hydrogels, a method was developed recently by anchoring NPs to a thio-modified LL37 peptide [ 112 ]. Upon subcutaneous implementation, no toxic effects were observed on human endothelial and cornea epithelial cells, with no significant interleukin-6 activation.…”

Section: Risk Management Of Npsmentioning

confidence: 99%

Toxicological Considerations, Toxicity Assessment, and Risk Management of Inhaled Nanoparticles

Bakand

Hayes

2016

IJMS

172

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Novel engineered nanoparticles (NPs), nanomaterial (NM) products and composites, are continually emerging worldwide. Many potential benefits are expected from their commercial applications; however, these benefits should always be balanced against risks. Potential toxic effects of NM exposure have been highlighted, but, as there is a lack of understanding about potential interactions of nanomaterials (NMs) with biological systems, these side effects are often ignored. NPs are able to translocate to the bloodstream, cross body membrane barriers effectively, and affect organs and tissues at cellular and molecular levels. NPs may pass the blood–brain barrier (BBB) and gain access to the brain. The interactions of NPs with biological milieu and resulted toxic effects are significantly associated with their small size distribution, large surface area to mass ratio (SA/MR), and surface characteristics. NMs are able to cross tissue and cell membranes, enter into cellular compartments, and cause cellular injury as well as toxicity. The extremely large SA/MR of NPs is also available to undergo reactions. An increased surface area of the identical chemical will increase surface reactivity, adsorption properties, and potential toxicity. This review explores biological pathways of NPs, their toxic potential, and underlying mechanisms responsible for such toxic effects. The necessity of toxicological risk assessment to human health should be emphasised as an integral part of NM design and manufacture.

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Section: Risk Management Of Npsmentioning

confidence: 99%

Toxicological Considerations, Toxicity Assessment, and Risk Management of Inhaled Nanoparticles

Bakand

Hayes

2016

IJMS

172

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“…These metal NPs possess strong antibacterial activity, photocatalytical activity, high surface area, and high drugloading capacity make these potential candidates for skin tissue repair. 38,39 Magnetite NPs providing high specific surface area and lower internal diffusion resistance loaded with Provided attachment and spreading of PC12 cells, exhibited better electrical property and promoted cell proliferation 184 Cornea Silver NPs Fabrication of corneal implants and lenses for cornea replacements 185 A combination of lipofection with silica ironoxide magnetic NPs…”

Section: Skin Tementioning

confidence: 99%

Nanomaterials as potential and versatile platform for next generation tissue engineering applications

et al. 2019

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Tissue engineering (TE) is an emerging field where alternate/artificial tissues or organ substitutes are implanted to mimic the functionality of damaged or injured tissues. Earlier efforts were made to develop natural, synthetic, or semisynthetic materials for skin equivalents to treat burns or skin wounds. Nowadays, many more tissues like bone, cardiac, cartilage, heart, liver, cornea, blood vessels, and so forth are being engineered using 3‐D biomaterial constructs or scaffolds that could deliver active molecules such as peptides or growth factors. Nanomaterials (NMs) due to their unique mechanical, electrical, and optical properties possess significant opportunities in TE applications. Traditional TE scaffolds were based on hydrolytically degradable macroporous materials, whereas current approaches emphasize on controlling cell behaviors and tissue formation by nano‐scale topography that closely mimics the natural extracellular matrix. This review article gives a comprehensive outlook of different organ specific NMs which are being used for diversified TE applications. Varieties of NMs are known to serve as biological alternatives to repair or replace a portion or whole of the nonfunctional or damaged tissue. NMs may promote greater amounts of specific interactions stimulated at the cellular level, ultimately leading to more efficient new tissue formation. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2433–2449, 2019.

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“…Furthermore, the opacity of the cornea was unaffected by the treatment. Also, the incorporation of nanosilver into collagen hydrogels can produce collagen mimetic matrices with antimicrobial properties (Alarcon et al, 2016). Sometimes point-specific corneal healing is insufficient and replacement is necessary.…”

Section: Corneal Regeneration or Replacement Using Bioactive Materialsmentioning

confidence: 99%

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.

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Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine

Cited by 77 publications

References 51 publications

Toxicological Considerations, Toxicity Assessment, and Risk Management of Inhaled Nanoparticles

Toxicological Considerations, Toxicity Assessment, and Risk Management of Inhaled Nanoparticles

Nanomaterials as potential and versatile platform for next generation tissue engineering applications

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

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