Colour vision impairment is associated with disease severity in multiple sclerosis

Martínez-Lapiscina, Elena H.; Ortiz-Pérez, Santiago; Fraga-Pumar, Elena; Martínez‐Heras, Eloy; Gabilondo, Iñigo; Llufriú, Sara; Bullich, Santiago; Figueras, Marc; Sáiz, Albert; Sánchez-Dalmau, Bernardo; Villoslada, Pablo

doi:10.1177/1352458513517591

Cited by 37 publications

(30 citation statements)

References 29 publications

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“…In this model including GCC thickness, thalamus volume, and lesions within the ORs, only GCC thickness remained statistically significant [OR = 0.89 95 % CI (0.81-0.98) p = 0.023]. When we added disease duration, age, and sex also as covariates to the previous model, the results were HRR scores have been linked to disease severity and neuroaxonal damage [6]. Moreover, Saidha S and colleagues have recently described that retinal atrophy parallels brain atrophy [20].…”

Section: Risk Of Dyschromatopsia By Retinal and Brain Damagementioning

confidence: 52%

“…Given that dyschromatopsia has been linked to disease severity and markers of diffuse neuroaxonal damage [6], we assessed the role of GCC thickness in dyschromatopsia development in MS independently of NBPV and T1 MPRAGE lesion load. We found that preserving one micron in GCC thickness was associated with a 12 % lower probability of color vision impairment.…”

Section: Discussionmentioning

confidence: 99%

“…Taken together, these findings indicate that MS can lead to damage along the entire color vision pathway [3][4][5]. However, while dyschromatopsia is well documented in MS patients, even in those without a history of Acute Optic Neuritis (AON) [6,7], the precise site of injury producing color vision impairment remains unknown. The strong correlation between quantitative color vision assessment scores and Optical Coherence Tomography (OCT) retinal measurements suggests that the primary process underlying acquired dyschromatopsia in MS patients is damage to the anterior visual pathway [8].…”

Section: Introductionmentioning

confidence: 99%

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Color vision impairment in multiple sclerosis points to retinal ganglion cell damage

et al. 2015

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Multiple Sclerosis (MS) results in color vision impairment regardless of optic neuritis (ON). The exact location of injury remains undefined. The objective of this study is to identify the region leading to dyschromatopsia in MS patients' NON-eyes. We evaluated Spearman correlations between color vision and measures of different regions in the afferent visual pathway in 106 MS patients. Regions with significant correlations were included in logistic regression models to assess their independent role in dyschromatopsia. We evaluated color vision with Hardy-Rand-Rittler plates and retinal damage using Optical Coherence Tomography. We ran SIENAX to measure Normalized Brain Parenchymal Volume (NBPV), FIRST for thalamus volume and Freesurfer for visual cortex areas. We found moderate, significant correlations between color vision and macular retinal nerve fiber layer (rho = 0.289, p = 0.003), ganglion cell complex (GCC = GCIP) (rho = 0.353, p < 0.001), thalamus (rho = 0.361, p < 0.001), and lesion volume within the optic radiations (rho = -0.230, p = 0.030). Only GCC thickness remained significant (p = 0.023) in the logistic regression model. In the final model including lesion load and NBPV as markers of diffuse neuroaxonal damage, GCC remained associated with dyschromatopsia [OR = 0.88 95 % CI (0.80-0.97) p = 0.016]. This association remained significant when we also added sex, age, and disease duration as covariates in the regression model. Dyschromatopsia in NON-eyes is due to damage of retinal ganglion cells (RGC) in MS. Color vision can serve as a marker of RGC damage in MS.

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Section: Risk Of Dyschromatopsia By Retinal and Brain Damagementioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Color vision impairment in multiple sclerosis points to retinal ganglion cell damage

et al. 2015

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“…39 In addition to impaired HCVA and LCVA, patients with MS are commonly found to have impaired color vision, both with and without a history of ON. [44][45][46] Recent studies using OCT have observed that performance in tests of color vision is strongly correlated with thickness of RNFL 43,47 and PMB, 43,47 as well as TMV, 47 in MS patients. These associations are stronger when using SD-OCT technology than with TD-OCT, reflecting the superior resolution and accuracy of the former.…”

Section: Relationship Of Oct Parameters With Clinical Outcome Measuresmentioning

confidence: 99%

Optical Coherence Tomography in Multiple Sclerosis

et al. 2016

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Retinal optical coherence tomography (OCT) has recently become a vital tool for clinicians and researchers in ophthalmology and, increasingly, in neurology. Optical coherence tomography is quickly and easily performed, well-tolerated by patients, and allows high-resolution viewing of unmyelinated axons and other retinal structures in vivo. These factors have led OCT to find favor as a method of quantifying neuroaxonal loss in multiple sclerosis (MS), and the increasing acceptance of the anterior visual pathway as a model to investigate MS in humans.In this short review, the authors discuss OCT findings in MS research, and the relationships of these structural findings with established functional outcome measures such as visual acuity and electrophysiological examinations. The utility of OCT in patients with acute optic neuritis is emphasized. Optical coherence tomography is a particularly powerful tool when the individual retinal layers are visualized and quantified following the segmentation of scans; this technique shows promise as a method for defining novel MS phenotypes.

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“…LCVA testing using 2.5% contrast charts has emerged from this work as a test that is sensitive for detecting visual disability and tracking it over time (9, 10). RNFL thickness is another informative outcome measure increasingly utilized in clinical practice and trials (6, 11) and color vision is frequently impaired in MS patients with and without a history of optic neuritis (12, 13). Because most of these tests have not been evaluated in patients with moderate to severe visual dysfunction, whether these instruments will be useful across the full spectrum of MS patients has yet to be established.…”

Section: Introduction1mentioning

confidence: 99%

Quantitative visual tests after poorly recovered optic neuritis due to multiple sclerosis

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et al. 2016

Multiple Sclerosis and Related Disorders

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Background Visual dysfunction in MS can be quantified using a variety of tests. Many vision tests have not been formally evaluated among MS patients with existing visual dysfunction. Objective Evaluate several versions of visual acuity and contrast sensitivity tests, measures of central and peripheral vision, retina structure, electrophysiologic function, and quality of life among MS patients with moderate/severe visual dysfunction. Methods Cross-sectional study of 46 patients with stable, incompletely recovered optic neuritis. Testing included Snellen eye charts, several Sloan low contrast charts, Pelli Robson (PR) contrast sensitivity charts, optical coherence tomography, visual fields, Farnsworth Munsell 100-hue test, visual evoked potentials (VEP), and visual function quality of life (VFQ-25) testing. Results 98% of eyes could read two lines of the PR chart, while only 43% read the 2.5% contrast chart. Low contrast tests correlated strongly with each other and with retinal nerve fiber layer (RNFL) thickness, visual fields, and color vision but not with VEPs. For patients with RNFL <75μm, VFQ-25 scores dropped by approximately 2 points for every 1 μm decrease in RNFL. Conclusion Among MS patients with visual impairment due to optic neuritis, PR contrast sensitivity could be utilized as a single chart. Visual quality of life was associated with RNFL thinning below 75μm.

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Colour vision impairment is associated with disease severity in multiple sclerosis

Abstract: Colour vision impairment is associated with greater MS severity.

Cited by 37 publications

References 29 publications

Color vision impairment in multiple sclerosis points to retinal ganglion cell damage

Color vision impairment in multiple sclerosis points to retinal ganglion cell damage

Optical Coherence Tomography in Multiple Sclerosis

Quantitative visual tests after poorly recovered optic neuritis due to multiple sclerosis

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