Colour and melanophore function in rainbow trout after long term exposure to the new antifoulant medetomidine

Lennquist, Anna; Lindblad, L.; Hedberg, Daniel; Kristiansson, Erik; Förlin, Lars

doi:10.1016/j.chemosphere.2010.05.014

Cited by 15 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…() used cultures of zebrafish embryos to perform a screen for small molecules that alter chromatophore development, which both confirmed earlier studies but also provided new insight into developmental processes that also could be of importance for testing of drugs. Fish scales with chromatophores can be maintained in vitro and were recently used for toxicological testing of a novel antifouling boat‐paint (Lennquist et al., ). Further development is ongoing with a combination of cell science, bioengineering, and information technologies.…”

Section: Color Change In Toxicology and Bio‐detectionmentioning

confidence: 99%

Rapid color change in fish and amphibians – function, regulation, and emerging applications

Sköld

Aspengren²,

Wallin

2012

Pigment Cell Melanoma Res

236

160

View full text Add to dashboard Cite

Summary Physiological color change is important for background matching, thermoregulation as well as signaling and is in vertebrates mediated by synchronous intracellular transport of pigmented organelles in chromatophores. We describe functions of and animal situations where color change occurs. A summary of endogenous and external factors that regulate this color change in fish and amphibians is provided, with special emphasis on extracellular stimuli. We describe not only color change in skin, but also highlight studies on color change that occurs using chromatophores in other areas such as iris and on the inside of the body. In addition, we discuss the growing field that applies melanophores and skin color in toxicology and as biosensors, and point out research areas with future potential.

show abstract

Section: Color Change In Toxicology and Bio‐detectionmentioning

confidence: 99%

Rapid color change in fish and amphibians – function, regulation, and emerging applications

Sköld

Aspengren²,

Wallin

2012

Pigment Cell Melanoma Res

236

160

View full text Add to dashboard Cite

show abstract

“…The interdisciplinary research program Marine Paint [2], in which our group has been a part, has since 2001 been investigating the substance medetomidine [29] (see Scheme 1) which is based on imidazole for antifouling purposes [30][31][32]. Medetomidine is exceptionally efficient against fouling barnacles [33], which is one of the most problematic foulants in the north Atlantic, yet, without seriously affecting nontarget organisms [34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Imidazole and Triazole Coordination Chemistry for Antifouling Coatings

Trojer

Movahedi

Blanck

et al. 2013

Journal of Chemistry

View full text Add to dashboard Cite

Fouling of marine organisms on the hulls of ships is a severe problem for the shipping industry. Many antifouling agents are based on five-membered nitrogen heterocyclic compounds, in particular imidazoles and triazoles. Moreover, imidazole and triazoles are strong ligands for Cu2+and Cu+, which are both potent antifouling agents. In this review, we summarize a decade of work within our groups concerning imidazole and triazole coordination chemistry for antifouling applications with a particular focus on the very potent antifouling agentmedetomidine. The entry starts by providing a detailed theoretical description of the azole-metal coordination chemistry. Some attention will be given to ways to functionalize polymers with azole ligands. Then, the effect of metal coordination in azole-containing polymers with respect to material properties will be discussed. Our work concerning the controlled release of antifouling agents, in particular medetomidine, using azole coordination chemistry will be reviewed. Finally, an outlook will be given describing the potential for tailoring the azole ligand chemistry in polymers with respect to Cu2+adsorption and Cu2+→Cu+reduction for antifouling coatings without added biocides.

show abstract

“…Skin pigmentation is a manifestation of self-protection for fish to adapt to the environment during evolution; however, numerous pollutants have been confirmed to induce skin pigmentation abnormalities [ 18 , 19 , 20 ]. BuP, as an emerging contaminant with endocrine-disrupting effects, can exert toxic effects on multiple tissues and organs after long-term exposure.…”

Section: Discussionmentioning

confidence: 99%

Butylparaben Exposure Induced Darker Skin Pigmentation in Nile Tilapia (Oreochromis niloticus)

Liu

Zhang

Liang³

et al. 2023

Toxics

View full text Add to dashboard Cite

Butylparaben (BuP), as an emerging contaminant with endocrine-disrupting effects, may exert effects on skin pigmentation in fish by interfering with the neuroendocrine system. Therefore, models of BuP exposure in Nile tilapia (Oreochromis niloticus) were established by adding different doses of BuP (0, 5, 50, 500, and 5000 ng/L) for 56 days. The obtained results showed that BuP exposure induced darker skin pigmentation, manifested as increased melanin content of skin, while genes related to melanin synthesis, including α-MSH and Asip2, significantly changed. In addition, BuP exposure reduced dopamine and γ-aminobutyric acid content in the brain, which is related to the synthesis of α-MSH. Furthermore, the release of neurotransmitters from the brain is affected by light. Thus, the relative gene expression levels in the phototransduction pathway were evaluated to explore the molecular mechanism of BuP-induced darker skin pigmentation, and the obtained results showed that Arr3a and Arr3b expression was significantly upregulated, whereas Opsin expression was significantly downregulated in a BuP dose-dependent manner, indicating that BuP inhibited phototransduction from the retina to the brain. Importantly, correlation analysis results showed that all melanin indexes were significantly positively correlated with Arr3b expression and negatively correlated with Opsin expression. This study indicated that BuP induced darker skin pigmentation in Nile tilapia via the neuroendocrine circuit, which reveals the underlying molecular mechanism for the effects of contaminants in aquatic environments on skin pigmentation in fish.

show abstract

Colour and melanophore function in rainbow trout after long term exposure to the new antifoulant medetomidine

Cited by 15 publications

References 33 publications

Rapid color change in fish and amphibians – function, regulation, and emerging applications

Rapid color change in fish and amphibians – function, regulation, and emerging applications

Imidazole and Triazole Coordination Chemistry for Antifouling Coatings

Butylparaben Exposure Induced Darker Skin Pigmentation in Nile Tilapia (Oreochromis niloticus)

Contact Info

Product

Resources

About