Colostral transfer of bovine immunoglobulin E and dynamics of serum IgE in calves

Abstract

The role of IgE in protective immunity is becoming understood, therefore the colostral transfer of IgE and the age-dependent changes of IgE levels may be important for neonatal immunity. To investigate this question, serum samples were collected from range-fed Hereford cows and their calves from birth through 9 months of age. The sera were assayed for total IgE during the first week postpartum, indicating colostral transfer of IgE. Thereafter, serum levels declined rapidly within 3 weeks from birth. The IgE levels began to increase after 12 weeks of age, and in some cases reached adult levels. The passive transfer of maternal IgE through colostrum may be important in providing early protection from disease, especially against intestinal parasites.

Colostrum Management for Dairy Calves

“…16 Although not well understood, colostral transfer of IgE also occurs and may be important in providing early protection against intestinal parasites. 19 After absorption into the calf's circulation, the duration of passive immunity from maternal Ig is highly variable and depends to a great extent on the total mass of Ig consumed and absorbed within the first 24 hours of life. The rate of decay of colostral antibodies can be influenced by multiple factors, including active viral infections or vaccination.…”

Colostrum Management for Dairy Calves

“…Smaller amounts of IgA and IgM are largely derived from local synthesis by plasmacytes in the mammary gland [13]. Although not well understood, colostral transfer of IgE also occurs and may be important in providing early protection against intestinal parasites [16].…”

Evolution of Immune Functions of the Mammary Gland and Protection of the Infant

“…79 In most mammals IgE is antiparasitic. In mice, IgE induces the production of mast cells from murine bone marrow precursors and increases their ability to produce certain cytokines.…”