Colormaps Of Computed Tomography Liver Perfusion Parameters Achieved Using Different Computing Methods Match

Reproducibility of Computed Tomography perfusion parameters in hepatic multicentre study in patients with colorectal cancer

“…The fitting procedure of both vascular and tissue signals was carried out by adopting two widely used parametric models, the Lagged Normal (LN) [33] and the Gamma Variate (GV) [34] functions, respectively, similarly to what done in [23]. The fitting procedure was performed using the Interior Point [35], a constrained nonlinear optimization algorithm implemented in the fmincon function of Matlab © (MathWorks Inc, Natick, MA, USA).…”

“…However, under the MS approach C T A (t) and C T P (t) cannot be analytically separated. Commonly (as in [23]), they are approximated according to Eqs. 15 and 16 [42]:…”

“…Therefore, attaining a common agreement between MS-and DV-based CTp parameter values is necessary to achieve the reproducibility of results [22], to improve the effectiveness of multicentre trials and favouring the CTp standardization. A first worthy attempt has been accomplished in [23], where a match between perfusion maps computed with MS and DV was achieved, on a reduced number of patients, just for visual purposes, with perfusion values min-max normalized, separately for MS and DV.…”