Colorimetric technique-based biosensors for early detection of cancer

Shahsavar, Kosar; Alaei, Aida; Hosseini, Morteza

doi:10.1016/b978-0-12-823424-2.00012-0

Cited by 6 publications

(2 citation statements)

References 59 publications

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“…Several optical sensing techniques, such as chemiluminescence, fluorescence, and colorimetric, are capable of detecting various types of cancer biomarkers. There are a number of unique advantages to colorimetric sensing, such as low costs and dispensing with complex tools and specialized personnel [49]. Color changes are visible to the naked eye, so sophisticated tools are not required for data analysis.…”

Section: Colorimetric Sensingmentioning

confidence: 99%

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Singh

Kumar

2022

Nanomaterials

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Cancer belongs to a category of disorders characterized by uncontrolled cell development with the potential to invade other bodily organs, resulting in an estimated 10 million deaths globally in 2020. With advancements in nanotechnology-based systems, biomedical applications of nanomaterials are attracting increasing interest as prospective vehicles for targeted cancer therapy and enhancing treatment results. In this context, carbon nanotubes (CNTs) have recently garnered a great deal of interest in the field of cancer diagnosis and treatment due to various factors such as biocompatibility, thermodynamic properties, and varied functionalization. In the present review, we will discuss recent advancements regarding CNT contributions to cancer diagnosis and therapy. Various sensing strategies like electrochemical, colorimetric, plasmonic, and immunosensing are discussed in detail. In the next section, therapy techniques like photothermal therapy, photodynamic therapy, drug targeting, gene therapy, and immunotherapy are also explained in-depth. The toxicological aspect of CNTs for biomedical application will also be discussed in order to ensure the safe real-life and clinical use of CNTs.

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Section: Colorimetric Sensingmentioning

confidence: 99%

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Singh

Kumar

2022

Nanomaterials

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“…Metal nanoclusters represent a transition between single-atom metals and metal nanoparticles . The nanocluster size range varies from 1 to 10 nm and is typically composed of up to 100 atoms. − Their ultra-small size is not the only characteristic that makes them different from nanoparticles; their physicochemical properties, such as the availability of a large number of surface active sites for catalytic reactions, discrete energy levels, and unique electronic properties, could differentiate them from nanoparticles . Similar to metal nanoparticles, metal nanoclusters can be synthesized following the top-down or bottom-up approaches involving chemical and/or physical methods, and the synthesis approach is normally complex involving multiple steps where toxic ligands (used as stabilizers and protecting agents), reducing agents, solvents, and high temperature or pressure are applied. , The presence of ligands on the surface of the metallic nanoclusters can decrease the catalytic activity by blocking the accessibility of the reactant to the nanocluster’s surface.…”

Section: Introductionmentioning

confidence: 99%

Facile Biological-Based Synthesis of Size-Controlled Palladium Nanoclusters Anchored on the Surface of Geobacter sulfurreducens and Their Application in Electrocatalysis

Jimenez-Sandoval

Pedireddy

Katuri

et al. 2023

ACS Sustainable Chem. Eng.

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Metal nanoclusters can be synthesized following the top-down or bottom-up approaches involving multiple chemical and/or physical steps where strong ligands, toxic chemicals, and high temperature and pressure are normally applied. In contrast, biological methods eliminate the use and generation of hazardous substances and do not require the application of high temperature and pressure during the synthesis process. Biological methods based on the extracellular electron transfer (EET) capability of electroactive bacteria (EAB) are considered a promising sustainable route for the synthesis of metal nanoparticles; however, a fine control of the size of the nanoparticles has not been achieved yet. Herein, we report a facile biological-based synthesis method of size-controlled palladium (Pd) nanoclusters using the EET capability of Geobacter sulfurreducens. By controlling the metal precursor concentrations and dosing and incubation times, we synthesized size-controlled Pd nanoclusters (1.0 ± 0.6 to 4.8 ± 1.4 nm) anchored on the surface of G. sulfurreducens. The as-synthesized Pd nanoclusters anchored on the surface of G. sulfurreducens cells (Pd/GS) were tested for their performance as bifunctional electrocatalysts for the overall alkaline water splitting reaction. Despite a very low mass loading of 0.002 mg Pd cm −2 , the hybrid material (i.e., Pd/GS) showed exceptionally higher activity for hydrogen evolution reaction (HER) when compared to benchmark 10 wt % Pt/C and Pd/C. Similarly, Pd/GS showed higher activity for oxygen evolution reaction (OER) when compared to Pd/C and comparable OER activity when compared to benchmark IrO 2 . The findings in this study provide a promising sustainable route for designing size-controlled metal nanoclusters anchored on the surface of EAB as efficient and low-cost electrocatalysts for various applications.

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