Colorimetric surface plasmon resonance imaging (SPRI) biosensor array based on polarization orientation

Wong, Chi Lok; Chen, George Chung Kit; Li, Xiaochao; Ng, Beng Koon; Shum, Ping; Chen, Peng; Lin, Zhiping; Lin, Chunqing; Olivo, Malini

doi:10.1016/j.bios.2013.02.040

Cited by 22 publications

(12 citation statements)

References 31 publications

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“…The SPR sensor is a sensitive label-free technique [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ] for the detection of bio-molecular interactions, such as antigen-antibody binding [ 18 , 19 ]. It also allows for a real-time response to facilitate rapid detection [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ], while the system cost is low compared to surface enhanced Raman spectroscopy (SERS) [ 29 , 30 ] and microscopy-based optical detection [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

A Phase-Intensity Surface Plasmon Resonance Biosensor for Avian Influenza A (H5N1) Detection

Wong

Chua

Mittman

et al. 2017

Sensors

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In this paper, we present a phase-intensity surface plasmon resonance (SPR) biosensor and demonstrate its use for avian influenza A (H5N1) antibody biomarker detection. The sensor probes the intensity variation produced by the steep phase response at surface plasmon excitation. The prism sensor head is fixed between a pair of polarizers with a perpendicular orientation angle and a forbidden transmission path. At SPR, a steep phase change is introduced between the p- and s-polarized light, and this rotates the polarization ellipse of the transmission beam. This allows the light at resonance to be transmitted and a corresponding intensity change to be detected. Neither time-consuming interference fringe analysis nor a phase extraction process is required. In refractive index sensing experiments, the sensor resolution was determined to be 6.3 × 10−6 refractive index values (RIU). The sensor has been further applied for H5N1 antibody biomarker detection, and the sensor resolution was determined to be 193.3 ng mL−1, compared to 1 μg mL−1 and 0.5 μg mL−1, as reported in literature for influenza antibody detection using commercial Biacore systems. It represents a 517.3% and 258.7% improvement in detection limit, respectively. With the unique features of label-free, real-time, and sensitive detection, the phase-intensity SPR biosensor has promising potential applications in influenza detection.

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Section: Introductionmentioning

confidence: 99%

A Phase-Intensity Surface Plasmon Resonance Biosensor for Avian Influenza A (H5N1) Detection

Wong

Chua

Mittman

et al. 2017

Sensors

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“…Biosensing with metasurfaces is closely related to surface plasmon polaritons (SPPs), which has been widely used for such applications [150][151][152][153][154][155][156][157][158][159]. However, the 2D periodic structures of metasurfaces can allow lower radiative damping loss at resonance and enable high quality factor detection with Fano resonance and plasmonic induced transparency [160].…”

Section: Antibodies and Proteinsmentioning

confidence: 99%

Metasurfaces for biomedical applications: imaging and sensing from a nanophotonics perspective

et al. 2020

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Metasurface is a recently developed nanophotonics concept to manipulate the properties of light by replacing conventional bulky optical components with ultrathin (more than 104 times thinner) flat optical components. Since the first demonstration of metasurfaces in 2011, they have attracted tremendous interest in the consumer optics and electronics industries. Recently, metasurface-empowered novel bioimaging and biosensing tools have emerged and been reported. Given the recent advances in metasurfaces in biomedical engineering, this review article covers the state of the art for this technology and provides a comprehensive interdisciplinary perspective on this field. The topics that we have covered include metasurfaces for chiral imaging, endoscopic optical coherence tomography, fluorescent imaging, super-resolution imaging, magnetic resonance imaging, quantitative phase imaging, sensing of antibodies, proteins, DNAs, cells, and cancer biomarkers. Future directions are discussed in twofold: application-specific biomedical metasurfaces and bioinspired metasurface devices. Perspectives on challenges and opportunities of metasurfaces, biophotonics, and translational biomedical devices are also provided. The objective of this review article is to inform and stimulate interdisciplinary research: firstly, by introducing the metasurface concept to the biomedical community; and secondly by assisting the metasurface community to understand the needs and realize the opportunities in the medical fields. In addition, this article provides two knowledge boxes describing the design process of a metasurface lens and the performance matrix of a biosensor, which serve as a “crash-course” introduction to those new to both fields.

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“…To date, SPRi sensors based on intensity [4,9,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31], angle [32,33,34,35,36,37,38], wavelength [39,40,41,42,43,44,45], phase [6,46,47,48,49,50,51,52,53,54,55], and polarization [28,38,56,57,58,59,60,61,62,63] interrogation have been widely reported.…”

Section: Optical Configurations Of Sprimentioning

confidence: 99%

“…A resolution of 10 −6 RIU was obtained which is limited by external temperature and intensity drifts. Since 2011, Wong et al [61,62,63] have developed spectral-phase SPRi sensors based on polarization control scheme. As shown in Figure 5, two polarizers with perpendicular transmission axes are configured in series so that the transmission of an incident beam is forbidden.…”

Section: Optical Configurations Of Sprimentioning

confidence: 99%

Recent Advances in Surface Plasmon Resonance Imaging Sensors

Wang

Loo

Chen

et al. 2019

Sensors

113

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The surface plasmon resonance (SPR) sensor is an important tool widely used for studying binding kinetics between biomolecular species. The SPR approach offers unique advantages in light of its real-time and label-free sensing capabilities. Until now, nearly all established SPR instrumentation schemes are based on single- or several-channel configurations. With the emergence of drug screening and investigation of biomolecular interactions on a massive scale these days for finding more effective treatments of diseases, there is a growing demand for the development of high-throughput 2-D SPR sensor arrays based on imaging. The so-called SPR imaging (SPRi) approach has been explored intensively in recent years. This review aims to provide an up-to-date and concise summary of recent advances in SPRi. The specific focuses are on practical instrumentation designs and their respective biosensing applications in relation to molecular sensing, healthcare testing, and environmental screening.

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Colorimetric surface plasmon resonance imaging (SPRI) biosensor array based on polarization orientation

Cited by 22 publications

References 31 publications

A Phase-Intensity Surface Plasmon Resonance Biosensor for Avian Influenza A (H5N1) Detection

A Phase-Intensity Surface Plasmon Resonance Biosensor for Avian Influenza A (H5N1) Detection

Metasurfaces for biomedical applications: imaging and sensing from a nanophotonics perspective

Recent Advances in Surface Plasmon Resonance Imaging Sensors

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