Colorimetric Schirmer strip for tear glucose detection

Kang, Byoung‐Hoon; Park, Moonseong; Jeong, Ki‐Hun

doi:10.1007/s13206-017-1405-7

Cited by 20 publications

(21 citation statements)

References 32 publications

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“…The response region contained gel-encapsulated B5 for measuring the tear glucose concentration. The microfluidic channel of the μPAD was used for collecting the same amount of human tears [16]. The procedures of folding the strip and injecting a trace amount of water on the strip were used to pre-concentrate the glucose and hence improve the sensitivity and limit of detection for glucose [16].…”

Section: Resultsmentioning

confidence: 99%

“…The microfluidic channel of the μPAD was used for collecting the same amount of human tears [16]. The procedures of folding the strip and injecting a trace amount of water on the strip were used to pre-concentrate the glucose and hence improve the sensitivity and limit of detection for glucose [16]. The carbopol polymer mixed with GOx was designed as an efficient glue to connect the sampling site with the response region (the region of gel mixed with GOx in Figure 1) and provide a biocompatible medium for glucose with B5 .…”

Section: Resultsmentioning

confidence: 99%

“…Glucose sensing μPADs were prepared with reference to Kang et al [16] and modified as follows. 5 µL of Complex B5 (1.6 × 10 −3 M) in dichloromethane was dropped onto the response region of the μPADs and Schirmer strips (Figure 1b,c).…”

Section: Methodsmentioning

confidence: 99%

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Detecting Glucose Levels in Blood Plasma and Artificial Tear by Au(I) Complex on the Carbopol Polymer: A Microfluidic Paper-Based Method

et al. 2018

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We report on a selective paper-based method and a microfluidic paper-based analytical device (μPAD) for the detection of human plasma glucose and tear glucose using carbopol polymer-encapsulated Au(I) complex (AuC2C6H4OMe)2(Ph2P(C6H4)3PPh2), (B5). To the best of our knowledge, this demonstrates for the first time the glucose sensing based on dual emission, i.e., fluorescence and phosphorescence, of a single type molecule on the carbopol polymer. Upon addition of human blood treated with anticoagulants to μPADs, plasma is separated from the blood and flows into the response region of the μPADs to react with carbopol polymer-encapsulated B5, in which the ratiometric luminescence is analyzed. The plasma glucose concentration can be quantitively detected at 1.0–50.0 mM on paper, and tear glucose can be detected at 0.1–4.0 mM on μPADs. Owing to the structural design, this device has superior ratiometric changes of dual emission over other Au(I) complexes for signal transduction. The encapsulation of carbopol polymer also offers long-term storage stability. In tear measurement, carbopol polymer is not only used to encapsulate enzyme to remain the enzyme’s activity, but also played as a glue (or media) to connect microfluidic channel and response region. This further improves the sensitivity and limit of detection for glucose. Moreover, this sensor provides a faster response time, a wider range for glucose sensing than reported previously, and no statistical difference of the data from a commercial glucometer, allowing for practical diagnosis of diabetes and healthy individuals.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Detecting Glucose Levels in Blood Plasma and Artificial Tear by Au(I) Complex on the Carbopol Polymer: A Microfluidic Paper-Based Method

et al. 2018

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“…As reported in previous studies, the band gap of CdS x Se 1−x films becomes larger with increasing x, varying from 1.74 eV (CdSe) to 2.45 eV (CdS), corresponding to the highest intensity of the samples, which matches well with our results. [25][26][27][28] Thus, the photoresponse of the three kinds of alloy nanowires of CdS, CdS 0.5 Se 0.5 , and CdSe is shown to be determined by the bandgap of nanowires, which could be engineered by controlling the mixing ratio of the source materials of the sintered target. 15,16) The I-V curves for the photosensors of CdS x Se 1-x ternary alloy nanowires (x = 0, 0.5, 1.0) at different synthesis zones were estimated with the intensity of incident light in the range of 7.9-33.4 (μW/cm 2 ) for the wavelength of 415 nm, 28.07-138.7 (μW/cm 2 ) for the wavelength of 502 nm and 8.8-66.4 (μW/cm 2 ) for the wavelength of 620 nm.…”

Section: In-situ Synthesis Of Cds X Se 1-x Ternary Alloy Nanowiresmentioning

confidence: 99%

Characterization of <italic>in-situ</italic> Synthesized CdSxSe1−x Ternary Alloy Nanowire Photosensor

Kim¹,

An²,

Chang³

et al. 2019

J. Korean Ceram. Soc

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CdS x Se 1-x ternary alloy nanowires (x = 0, 0.5, 1.0) were fabricated by in-situ synthesis on interdigitated electrode. Morphology analysis of the alloy nanowires according to the synthesis zone and composition analysis of the nanowires were carried out by SEM and EDX. The crystal structures of the alloy nanowires were studied by XRD analysis. The I-V characteristics of the nanowire photosensors were analyzed according to the intensity of incident light. The influence of zonal synthesis position on the photosensor response to the wavelength of incident light was also analyzed, and was found to be related to the bandgap of alloy nanowires. The analysis results indicate that photosensors with a specific photoresponse could be selected based on the composition of the source materials of nanowires as well as by controlling the in-situ synthesis zone.

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“…However, additional processes such as nanofabrication or gel casting are required to form a sieving matrix in typical glass or PDMS based chips [25,26]. Several advent of microfluidic paper-based analytical devices (μPADs) overcome complexity in fabrication [27][28][29][30]. The micro-/nanoscale cellulose pores inherent in paper allow high resolution separation of molecules without additional processes for the sieving matrix [31,32].…”

Section: Introductionmentioning

confidence: 99%

On-chip Paper Electrophoresis for Ultrafast Screening of Infectious Diseases

Kang

et al. 2021

BioChip J

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The outbreak of new viral strains promotes advances in universal diagnostic techniques for detecting infectious diseases with unknown viral sequence. Long double-stranded RNA (dsRNA), a hallmark of infections, serves as a virus marker for prompt detection of viruses with unknown genomes. Here, we report on-chip paper electrophoresis for ultrafast screening of infectious diseases. Negatively charged RNAs pass through the micro and nanoscale pores of cellulose in order of size under an external electric field applied to the paper microfluidic channel. Quantitative separation of long dsRNA mimicking poly I:C was analyzed from 1.67 to 33 ng·μL−1, which is close to the viral dsRNA concentration in infected cells. This paper-based capillary electrophoresis chip (paper CE chip) can provide a new diagnostic platform for ultrafast viral disease detection at the point-of-care (POC) level.

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Colorimetric Schirmer strip for tear glucose detection

Cited by 20 publications

References 32 publications

Detecting Glucose Levels in Blood Plasma and Artificial Tear by Au(I) Complex on the Carbopol Polymer: A Microfluidic Paper-Based Method

Detecting Glucose Levels in Blood Plasma and Artificial Tear by Au(I) Complex on the Carbopol Polymer: A Microfluidic Paper-Based Method

Characterization of <italic>in-situ</italic> Synthesized CdSxSe1−x Ternary Alloy Nanowire Photosensor

On-chip Paper Electrophoresis for Ultrafast Screening of Infectious Diseases

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