Colorimetric microdetermination of captopril in pure form and in pharmaceutical formulations

Shama, S. A.; Amin, Alla El-Sayed; Omara, Hany A.

doi:10.1016/j.jqsrt.2006.02.012

Cited by 23 publications

(11 citation statements)

References 14 publications

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“…It is well known that captopril, owing to the presence of the thiol group (-SH) in its structure, undergoes redox reaction with different oxidants in acid media, such as Fe(III), 20,27,30 Ce(IV); 18 Mn(VII), 25 bromine, generated in situ by the action of acid on a bromate-bromide mixture, 26 KBrO 3 , 28 KIO 3 , 22 chloramine-T. 21,23 In this work, dichromate was chosen as the oxidative agent. The ability of Cr(VI) to oxidize the CP was exploited for indirect determination of the drug.…”

Section: Resultsmentioning

confidence: 99%

“…As can be seen in this table, some of the reported procedures have higher detection limits. 21,25,[28][29][30]33 Limit of detection (LOD) and limit of quantification (LOQ) were calculated as follows:…”

Section: Analytical Parameters Of Spectrophotometric Methodsmentioning

confidence: 99%

“…19 Numerous spectrophotometric methods have also been proposed for CP determination. 1,[20][21][22][23][24][25][26][27][28][29][30][31][32][33] Generaly, these approaches involve the use of reagents that react with this compound to form species with absorb in the visible region. The US Pharmacopoeia recommends volumetric and HPLC methods for the assay in bulk and tablet formulations.…”

Section: Introductionmentioning

confidence: 99%

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Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Moldovan

Badea

Bunaciu³

et al. 2012

Quím. Nova

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Recebido em 21/9/11; aceito em 6/4/12, publicado na web em 3/7/12 A spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 μg mL -1. The assay limits of detection and quantitation were 0.024 and 0.08 μg mL -1 , respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.

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Section: Resultsmentioning

confidence: 99%

Section: Analytical Parameters Of Spectrophotometric Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Moldovan

Badea

Bunaciu³

et al. 2012

Quím. Nova

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show abstract

“…The suggested mechanism [31,32] and determine the unreacted oxidant by measuring the decrease in absorbance of dyes at their λ max as shown in (Figures 1,2). …”

Section: Resultsmentioning

confidence: 99%

Spectrophotometry Microdetermination of Some Antihypertensive Drugs in Pure Form and in Pharmaceutical Formulations

Shama

Amin

Omara

2011

J. Chil. Chem. Soc.

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Simple, rapid, accurate, precise and sensitive spectrophotometric method for the microdetermination of enalapril maleate (ENM) and lisinopril dihydrate (LIS) has been developed. The method is based on oxidation of the drug by potassium permanganate in acidic medium and determine the unreacted oxidant by measuring the decrease in absorbance for three different acidic dyes; acid red 73 (AR), amaranth dye [acid red 27] (AM) and acid orange 7 (AO) at a suitable λ max (510, 521 and 484 nm for ENM and 509, 521 and 485 nm for LIS), respectively. Regression analysis of Beer's law plots showed good correlation in the concentration ranges 0.7-12, 0.5-7.6 and 0.6-9.5 µg mL -1 and 0.5-9.0, 0.4-6.1 and 0.4-7.2 µg mL -1 for ENM and LIS using AR, AM and AO, respectively. The apparent molar absorptivity, Sandell sensitivity, detection and quantitation limits are calculated. Statistical treatment of the results reflects that the proposed procedures are precise, accurate and easily applicable for the determination of ENM and LIS in pure and in pharmaceutical preparations.

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“…7 Some analytical techniques have been employed for CPT and NAC determination. Luminometric, 8 spectrophotometric, [9][10][11] electroanalytical 12-15 and titrimetric 16 methods have been proposed for independent determination of one among these large consumed drugs in batch mode. The application of the same pattern reaction to determine these thiol drugs was reported by exploring the reaction with 1,2-naphthoquinone-4-sulfonic acid to develop a fluorimetric method in batch mode.…”

Section: Introductionmentioning

confidence: 99%

Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations

Chagas¹,

Santos²,

Santos³

et al. 2009

J. Braz. Chem. Soc.

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em meio ácido. A ordem de adição de reagentes foi avaliada e os parâmetros analíticos foram otimizados. As faixas lineares de concentração foram de 2,5-90 e de 5,0-50 mg L -1 para CPT e NAC, respectivamente. Os limites de detecção (3σ) foram calculados em 0,22 e 1,8 mg L -1 e desvios padrão relativos (N = 10) foram inferiores que 1,0 e 2,1% para CPT e NAC, respectivamente. O procedimento foi empregado para a determinação de CPT e NAC em diversas formulações farmacêuticas e os resultados concordaram com os obtidos pelos métodos de referência para 95% de confiabilidade aplicando teste-t pareado.A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on the reaction with iminoquinone radical produced from the N,N-dimethyl-p-phenilenediamene (DMPD) oxidation in acid medium. The reagents addition order was evaluated and analytical parameters were optimized. The linear concentrations ranges were 2.5-90 and 5.0-50 mg L -1 for CPT and NAC, respectively. Limits of detection (3σ) were calculated at 0.22 and 1.8 mg L -1 and the relative standard deviation (N = 10) were lower than 1.0 and 2.1% for CPT and NAC, respectively. The procedure was employed for CPT and NAC determination in diverse pharmaceutical formulations and by applying paired t-test the results were in agreement with those obtained by reference methods for 95% confidence level.

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Colorimetric microdetermination of captopril in pure form and in pharmaceutical formulations

Cited by 23 publications

References 14 publications

Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Spectrophotometry Microdetermination of Some Antihypertensive Drugs in Pure Form and in Pharmaceutical Formulations

Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations

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