“…Different spectrophotometric methods have been applied for the determination of phenylephrine with different reagents such as 4-aminoantipyrine in presence of periodate or alkaline ferricyanide (Al-Abachi and Al-Ward, 2002;Hiskey and Levin, 1960) , nitrous acid in presence of copper ion (Yahia and Laila, 1976) , chloranil (Amer et al, 1982) , ninhydrin in sulphuric acid (Muszalska et al, 2000), periodate (Neil and Gelenn, 1971), methylbenzothiazoline-2-one hydrazone in presence of iron (Gala et al, 1994), haematoxylin (Ibrahim;Alaa,2007), 4-aminophenol (Sane and Narkar,1980), chloramine (Szekerer et al, 1973), N,N-dimethylaniline hydrochloride with potassium ferricyanide (Tatsuzawa and Shimoda, 1968), hydroxyl ammonium chloride with cupric ion (Deodhar and Mehta, 1978), sodium borate (Doulakas, 1975), fluorodinitrobenzene (Tammilehto, 1975), bromothymol blue (Matthew et al,1972), and diazotized p-nitroaniline (Auerbach, 1950;Kelly and Auerbach, 2006). Also, the ultraviolet (Fabrizo, 2006) and derivative spectrophotometry (Kazemipour and Ansari, 2005) methods have been used.…”