Colorimetric Determination of Local Anesthetic Compounds

Bandelin, F.J.; Kemp, C.R.

doi:10.1021/i560156a004

Cited by 15 publications

(4 citation statements)

References 3 publications

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“…The use of A -acyl substituent containing a free primary amino group (see compound 6, Table I) was successful. The hydrolysis rate found for the N-(p -aminophenylacetyflalanine (6) was, in fact, of the same order as that found for the N-( phenylacetyl)alanine (7), one of the best substrates of BPA. In order to determine if the high susceptibility of the p-aminophenylacetyl group is retained even in the case of the derivatives of primary amines, the hydrolysis of AMp-aminophenylacetyl)-2-aminobutane (8) was examined and compared with that of the A/-(phenylacetyl) -2-aminobutane (16).…”

Section: Resultssupporting

confidence: 69%

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Approach to the use of benzylpenicillin acylase for configurational correlations of amino compounds. 2. Hydrolysis of N-(p-aminophenylacetyl) derivatives of some chiral primary amines

Rossi¹,

Calcagni²,

Romeo³

1979

J. Org. Chem.

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Section: Resultssupporting

confidence: 69%

“…In the IR spectrum (CHC13) all compounds showed strong absorption at 3400, 2920,1640, and 1500 cm-1. 6 All compounds were crystallized from ethyl acetate-hexane unless otherwise specified. c Yield based on starting amine.…”

Section: Resultsmentioning

confidence: 99%

Approach to the use of benzylpenicillin acylase for configurational correlations of amino compounds. 2. Hydrolysis of N-(p-aminophenylacetyl) derivatives of some chiral primary amines

Rossi¹,

Calcagni²,

Romeo³

1979

J. Org. Chem.

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“…One approach is to determine PNA in mixtures by a method which depends on the amine functionality. This can be done by modification of the method of Bandelin and Kemp (8) which involves diazotizing the amine and coupling with N-(1 -napthylamine)ethylenediamine to produce an azo dye with Xmax = 550 ± 5 nm. Addition of an unknown containing 3-64 ag PNA in 5 ml 10% H2SO4 to 25 µ 0.1% NaNOa formed the diazonium salt.…”

Section: Trace Determination Of Vacor Rodenticide By Pulse Polarographymentioning

confidence: 99%

Trace determination of Vacor rodenticide by pulse polarography

Whittaker¹,

Osteryoung²

1976

Anal. Chem.

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Q Botch Mode 0 Continuous Mode 10-6 2 3 4 5 7 10-1 WEIGHED PARTICLE CONCENTRATION IN SAMPLE, gm/ml Figure 6. Check of particle mass calculated from population counts and directly weighedmates of minimum secondary coincidence error. Corrected counts were obtained simply by subtracting the intercepts from the corresponding observed number at any total particle concentration. The mass of particles calculated from corrected counts was plotted in Figure 5. The corrected points show a better agreement with the lower solid line (weighed) than the uncorrected points. It is clear from Figure 5 that most of the error was due to the secondary effect. In plotting the corrected mass, the 3% or so mass that remained below the threshold of channel 13 was ignored.Significant error in material balance can result from errors such as the existence of spurious counts, as evidenced in Figure 5. A material balance check on the population counts therefore is important. The mass obtained from counting (Equation 1) is plotted vs. the expected mass (from weighing) in Figure 6 for various narrow-size particles using both the batch and continuous modes of counting. Considering the smallness of the numbers, the agreement is satisfactory. No consistent bias was observed in the results of the mass balance experiments. CONCLUSIONSIt has been demonstrated in the present work that the Model T Coulter Counters are accurate in the population mode. Spurious counts, however, existed for particles at the low-size end of the distribution below the threshold size of the measurement spectrum. Secondary coincidence error is in-dicated to be a problem in continuous crystal size distribution analysis. Such analyses are always based on a finite segment of size, but the distribution being measured is continuous and contains large numbers of particles below the lowest size scanned by the Coulter Counter. Some account of the excessive spurious counts that are expected in the lowest size channels has to be made to avoid erroneous conclusions. NOMENCLATURE K , = volumetric shape factor = mid-channel size, pm m, = calculated mass, g m, = weighedmass, g N = total true number of particles n = total observed number of particles Ani = average number in channel i t = time, min V = volume of stock suspension, ml Y = volume of suspension used for counting, ml a = sensing volume of an aperture, ml p = density of particles, g/cm3 r = average retention time, minutes LITERATURE CITED

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“…He reports a similar study for demerol (112), for hydrastis and its principal alkaloids, hydrastine and berberine (114), and together with Warren (118), has described the crystallographic data which serve to differentiate the four principal alkaloids of cinchonaquinine, quinidine, cinchonine, and cinchonidine. The adaptation of the method of Bratton and Marshall (SO) for the determination of sulfonamide derivatives to the colorimetric determination of local anesthetic agents is discussed by Bandelin and Kemp (11). Benzocaine, procaine hydrochloride, butacaine sulfate, and butyl aminobenzoate give positive tests while sulfonamides interfere.…”

Section: Alkaloids and Related Substancesmentioning

confidence: 99%

Pharmaceuticals and Natural Drugs

Hilty¹

1949

Anal. Chem.

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Colorimetric Determination of Local Anesthetic Compounds

Cited by 15 publications

References 3 publications

Approach to the use of benzylpenicillin acylase for configurational correlations of amino compounds. 2. Hydrolysis of N-(p-aminophenylacetyl) derivatives of some chiral primary amines

Approach to the use of benzylpenicillin acylase for configurational correlations of amino compounds. 2. Hydrolysis of N-(p-aminophenylacetyl) derivatives of some chiral primary amines

Trace determination of Vacor rodenticide by pulse polarography

Pharmaceuticals and Natural Drugs

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