Colorimetric detection of insulin in human serum using GO/AuNPs/TX-100 nanocomposite

Mirsalari, Marzieh; Elhami, Shahla

doi:10.1016/j.saa.2020.118617

Cited by 16 publications

(6 citation statements)

References 45 publications

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“…On the other hand, colorimetric techniques have the advantage of being low cost, simple and by the naked eye allows quantitative or semi-quantitative detection of a target analyte through a color change, but its main disadvantage is that it is generally less sensitive [ 141 ]. In the case of colorimetric platforms for AD biomarkers, many have limits of detection at the nanomolar level (nM) of concentration, which is not sufficient for clinical applications.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported the development of portable optical sensing platforms [ 145 , 146 , 147 ]. Miniaturized platforms, as capillary, paper, and fiber-based would be very useful for AD detection due to their low cost, portability, and reduction of sample volume to be analyzed [ 141 ], which is important for a potential application in clinical diagnosis and multiplexed detection.…”

Section: Discussionmentioning

confidence: 99%

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Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Oyarzún

Tapia-Arellano

Cabrera

et al. 2021

Sensors

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Alzheimer’s disease (AD), considered a common type of dementia, is mainly characterized by a progressive loss of memory and cognitive functions. Although its cause is multifactorial, it has been associated with the accumulation of toxic aggregates of the amyloid-β peptide (Aβ) and neurofibrillary tangles (NFTs) of tau protein. At present, the development of highly sensitive, high cost-effective, and non-invasive diagnostic tools for AD remains a challenge. In the last decades, nanomaterials have emerged as an interesting and useful tool in nanomedicine for diagnostics and therapy. In particular, plasmonic nanoparticles are well-known to display unique optical properties derived from their localized surface plasmon resonance (LSPR), allowing their use as transducers in various sensing configurations and enhancing detection sensitivity. Herein, this review focuses on current advances in in vitro sensing techniques such as Surface-enhanced Raman scattering (SERS), Surface-enhanced fluorescence (SEF), colorimetric, and LSPR using plasmonic nanoparticles for improving the sensitivity in the detection of main biomarkers related to AD in body fluids. Additionally, we refer to the use of plasmonic nanoparticles for in vivo imaging studies in AD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Oyarzún

Tapia-Arellano

Cabrera

et al. 2021

Sensors

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“…In fact, Au-based colorimetric sensors are among the most promising analytical methods for providing a rapid, simple, sensitive, and cost-effective way to detect target analytes. AuNPs have been applied to the detection of insulin in human serum (Mirsalari & Elhami, 2020), polyaromatic hydrocarbons (C.-M. Ma et al, 2022), melamine in milk samples (Xinran Hu, Chang, et al, 2018), glucose sensing (H. He et al, 2012), and breast cancer SK-BR-3 cell lines (Wentong Lu et al, 2010). Beside this type of setup, lateral flow immunoassays are also a type of colorimetric sensors that has been gaining wide application in the diagnostics field for simple and rapid detection of analytes (see Box 2).…”

Section: Aunps Colorimetric-based Sensingmentioning

confidence: 99%

Engineering gold nanoparticles for molecular diagnostics and biosensing

Oliveira

Ferreira

Fernandes

et al. 2022

WIREs Nanomed Nanobiotechnol

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Advances in nanotechnology and medical science have spurred the development of engineered nanomaterials and nanoparticles with particular focus on their applications in biomedicine. In particular, gold nanoparticles (AuNPs) have been the focus of great interest, due to their exquisite intrinsic properties, such as ease of synthesis and surface functionalization, tunable size and shape, lack of acute toxicity and favorable optical, electronic, and physicochemical features, which possess great value for application in biodetection and diagnostics purposes, including molecular sensing, photoimaging, and application under the form of portable and simple biosensors (e.g., lateral flow immunoassays that have been extensively exploited during the current COVID-19 pandemic). We shall discuss the main properties of AuNPs, their synthesis and conjugation to biorecognition moieties, and the current trends in sensing and detection in biomedicine and diagnostics. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vitro Nanoparticle-Based Sensing Diagnostic Tools > In Vivo Nanodiagnostics and Imaging K E Y W O R D S biodetection, bioimaging, diagnostics, gold nanoparticles, nanomedicine 1 | INTRODUCTION 1.1 | Nanoparticles for diagnosticsNanoparticle-based diagnosis has relied strongly on the continuous progresses in nanoscience and nanotechnology, particularly on the discovery and characterization of new nanomaterials and their applications in biomedicine. Several of these developments have stemmed from the fundamental research on the properties and functions of nanomaterials, where metal nanoparticles have a prominent position, particularly those of gold, iron, silver, platinum, copper, and cobalt (Doria et al., 2012;Habibullah et al., 2021).Beatriz B. Oliveira and Daniela Ferreira contributed equally to this study.

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“…The colorimetric approach was used to measure insulin concentrations between 2 and 300 ng/ml with a LOD of 0.1 ng/ml. [218] For insulin measurement, a novel bio-assay on the biocompatible PVA and borax hydrogel modified silver dots (PBH@AgD) platform was developed. In the presence of insulin the fluorescence of PBH@AgD was likewise increased.…”

Section: Insulin Sensingmentioning

confidence: 99%

Recent advances in nanomaterials‐based optical sensors for detection of various biomarkers (inorganic species, organic and biomolecules)

Harshita

Kailasa

2022

Luminescence

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This review briefly emphasizes the different detection approaches (electrochemical sensors, chemiluminescence, surface‐enhanced Raman scattering), functional nanostructure materials (quantum dots, metal nanoparticles, metal nanoclusters, magnetic nanomaterials, metal oxide nanoparticles, polymer‐based nanomaterials, and carbonaceous nanomaterials) and detection mechanisms. Furthermore, the emphasis of this review is on the integration of functional nanomaterials with optical spectroscopic techniques for the identification of various biomarkers (nucleic acids, glucose, uric acid, oxytocin, dopamine, ascorbic acid, bilirubin, spermine, serotonin, thiocyanate, Pb2+, Cu2+, Hg2+, F−, peptides), and cancer biomarkers (mucin 1, prostate specific antigen, carcinoembryonic antigen, CA15‐3, human epidermal growth factor receptor 2, C‐reactive protein, and interleukin‐6). Analytical characteristics of nanomaterials‐based optical sensors are summarized in the tables, providing the insights of nanomaterials‐based optical sensors for biomarkers detection. Finally, the opportunities and challenges of nanomaterials‐based optical analytical approaches for the detection of various biomarkers (inorganic, organic, biomolecules, peptides and proteins) are discussed.

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Colorimetric detection of insulin in human serum using GO/AuNPs/TX-100 nanocomposite

Cited by 16 publications

References 45 publications

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Engineering gold nanoparticles for molecular diagnostics and biosensing

Recent advances in nanomaterials‐based optical sensors for detection of various biomarkers (inorganic species, organic and biomolecules)

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