Colorimetric chemosensor of symmetrical benzoylthiourea derivatives as for detection of Cu2+ in aqueous solution

Hamedan, N. A.; Hasan, Sharizal; Zaki, Hamizah Mohd; Alias, Nurul Zawani

doi:10.1088/1757-899x/172/1/012038

Cited by 10 publications

(9 citation statements)

References 2 publications

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“…There are reports in literature wherein acyl thiourea derivatives have been used as a probe for detection of Cu 2+ ion [16][17][18] Hence, we were motivated to assess the application of NG1 as a sensor for metal ions. Thus, to assess the sensing properties of probe NG1, experiments were performed by co-incubating NG1 with a series of divalent metal ions.…”

Section: Methodsmentioning

confidence: 99%

A novel sensor for sequential and cellular detection of copper and lactic acid

Gour

Kharbanda²,

Pandey³

et al. 2020

Preprint

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<div> We report self assembling/aggregation properties of acyl-thiourea derivative, N-((6-methoxy-pyridin-2-yl)carbamothioyl)benzamide<a>(NG1) </a><a>[i1]</a> and the disaggregation induced emission which leads to its application as fluorescence and colorimetric probe for the sensitive detection of Cu2+. The microscopy analysis of NG1via SEM, and AFM reveal that it self-assembles to give fiber-like morphologies.Interestingly,NG1 also assembles to fluorescent fibers which show tunable emission properties. Addition of Cu2+to these fibers causedisruption/disaggregation of fibers and a golden yellow fluorescence is produced due to disaggregation induced emission enhancement (DIEE). The application of NG1 as selective sensor for copper was further assessed by UV visible and fluorescence spectroscopy. Limit of Detection(LOD) of Cu2+ with colorimetry was 2.5ppm while LOD of Cu2+ with fluorescence was as low as 0.1ppm. This yellow fluorescence is quenched after the addition of lactic acid and hence NG1 could potentially be used for the sequential detection of both Cu and lactate.Further, structural modification of the probe NG1 suggest crucial role of both pyridine and acyl-thiourea moiety in the binding of Cu2+. The experimental results of interaction of NG1 with Cu2+ and lactate were also validated theoretically by quantum chemical calculations based on density functional theory (DFT). Finally, we explore the ability of NG1for the sequential detection of Cu2+ and lactate in cells, which suggestsNG1 can be used effectively for the cellular imaging applications and to selectively sense Cu2+. To, the best of our knowledge,</div> this is the first report wherein a dual sensor for Cu2+and lactate ion is synthesized and it may in allpossibilities pave the way for the diagnosis of Cu2+associated disorders like Wilson’s disease and in the detection of elevated lactate levels which are associated with the wide range of pathologies likemitochondrial diseases, cerebral ischemia and cancer. <div> </div>

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Section: Methodsmentioning

confidence: 99%

A novel sensor for sequential and cellular detection of copper and lactic acid

Gour

Kharbanda²,

Pandey³

et al. 2020

Preprint

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“…Hamedan et al 97 synthesized symmetrical benzoyl thiourea derivative 120 and used it as a colorimetric sensor for the naked-eye detection of Cu 2+ ions. This sensor like the previous example displayed selectivity towards Cu 2+ ions in ACN/H 2 O binary solutions, thus benzoylthiourea 120 plays a vital role in colorimetric recognition.…”

Section: Applicationsmentioning

confidence: 99%

Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review

et al. 2022

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“…The method used for analysis on the application was based on a study with some modifications (Hamedan et al, 2017). The concentration for compounds M and MI in this step were fixed at 1x10 -5 M while the concentrations for Cd 2+ ion were 0.5x10 -5 M and 1x10 -5 M. 0.00508 g of MI and 0.00560 g of M were dissolved with saturated methanol in 25 mL volumetric flask.…”

Section: Preparation Of CD 2+ Ion and Probe Solutionmentioning

confidence: 99%

“…Then from the stock 0.5x10 -5 M and 1x10 -5 M of Cd 2+ ions were prepared by transferring 0.5 µL, 10 µL and 0.1 mL into three separated 10 mL volumetric flask and saturated methanol was added until calibration mark. All solutions were left aside for 30-60 minutes to allow them to dissolve completely in methanol solution (Hamedan et al, 2017).…”

Section: Preparation Of CD 2+ Ion and Probe Solutionmentioning

confidence: 99%

A Preliminary Study on Detection of Cadmium (Ii) Ion Using Benzoyl Phenylthiourea

Nasri¹,

Jumal²

2020

J. wast. bio. manag.

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Two benzoyl phenylthiourea derivatives namely: 1-benzoyl-3-(4-bromophenyl)-2- thiourea (M) and 1-(4-chlorobenzoyl)-3-(4-methylphenyl)-2-thiourea (MI) were successfully synthesized and characterized by using Carbon, Hydrogen and Nitrogen (CHN) micro elemental analysis, Fourier Transform Infra-Red (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy methods. Elemental analysis for M (C14H11N2SOBr) and MI (C15H13N2SOCl) were compatible with the expected theoretical calculation. The FTIR spectrum obtained for M and MI compounds show the presence of four important functional groups; ʋ(N-H), ʋ(C=O), ʋ(C-N) and ʋ(C=S) that appeared at 3380-3367 cm-1, 1666-1681 cm-1, 1342-1268 cm-1 and 1146-1152 cm-1, respectively. The NMR spectrum data for MI shows the chemical shift at 6.63-7.85 ppm for Ar-H group, 2.26-2.40 ppm for methyl group, 7.44 ppm for N1H and 3.09 ppm for N2H. For the application, M and MI were used as probes in detecting Cd2+ in methanol solution. UV-Visible spectrophotometer was used to analyze the absorbance values of the compound before and after Cd2+ was added. It is found that compound M displayed the behavior of ‘turn off’ sensors while compound MI possessed the behavior of ‘turn on’ when detecting 0.5×10-5 M and 1×10- 5 M of Cd2+ ion. The behavior of ‘turn on’ and ‘turn off’ is due to the increasing or decreasing of absorbance when Cd2+ was added to the compounds.

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Colorimetric chemosensor of symmetrical benzoylthiourea derivatives as for detection of Cu²⁺ in aqueous solution

Cited by 10 publications

References 2 publications

A novel sensor for sequential and cellular detection of copper and lactic acid

A novel sensor for sequential and cellular detection of copper and lactic acid

Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review

A Preliminary Study on Detection of Cadmium (Ii) Ion Using Benzoyl Phenylthiourea

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