Colorimetric Assay of Aspirin Using Modified Method

Abdulkadir, Maadh Q.; Al-Mudhafar, May Mohammed Jawad; Mohammed, Amera Abbas; Alzahawie, Suha K.

doi:10.22401/jnus.12.3.01

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…This was overcome by using an acidified solution of FeCl3.6H2O to neutralize excess sodium hydroxide. The absorbance spectra of violet colored aspirin complex showed maximum absorbance at 530 nm as shown in Figure 4, which follows previous studies (17).…”

Section: Preliminary Studiessupporting

confidence: 88%

“…Aspirin has been successfully determined by oxidation-reduction reaction with KMnO4 (16). The most commonly used methods for the quantitative analysis of aspirin are spectrophotometric in which Fe(III) salts are used as coloring reagents to form a violet complex, the absorbance of which is used as a measure of aspirin quantitatively (17). In 2006, Kohl et al showed that similar absorbance work could easily be performed by using colored solutions and digital images obtained with charge-coupled devices (18).…”

Section: Introductionmentioning

confidence: 99%

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A Novel Method to Assay Aspirin in Pharmaceutical Formulations by Smartphone Camera-Based Image Scanning Densitometry

KHAN,

ANWAR

2024

Journal of the Turkish Chemical Society Section A: Chemistry

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Aspirin, a widely-used anti-inflammatory drug, can lead to serious consequences when overdosed. Therefore, there's a need for simple, cost-effective methods to determine its concentration and mitigate potential risks. This study aimed to develop a method for assessing aspirin in pharmaceutical preparations without the need for expensive equipment and with minimal sensitivity to ambient light. In this work, aspirin was subjected to a reaction with Fe(III), leading to the formation of violet-colored spots on filter paper and a 96-microwell plate. These colored spots were then captured using a smartphone in normal lighting conditions and analyzed on a computer. The integrated density of each spot was measured using a novel grayscale technique, and a calibration curve was created to relate integrated density to aspirin concentration. Analytical parameters and reagent concentrations were optimized for accuracy. To validate the method, three commercial aspirin samples were assayed and compared to ultraviolet-visible spectrophotometry, a reference method. The developed technique demonstrated excellent precision (coefficient of variation <0.68%) and relative errors below 5.2%. When compared to traditional color models like red-green-blue (RGB) and hue-saturation-luminosity (HSL), the grayscale model showed superior correlation (R2> 0.996), while the RGB model yielded less precise results (R2= 0.792). This study showcased the effectiveness of a cost-effective methodology for accurate aspirin quantification using a smartphone camera, even in the presence of ambient light.

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Section: Preliminary Studiessupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

A Novel Method to Assay Aspirin in Pharmaceutical Formulations by Smartphone Camera-Based Image Scanning Densitometry

KHAN,

ANWAR

2024

Journal of the Turkish Chemical Society Section A: Chemistry

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“…Different formulations (about 500 mg each) of Rivo, Rivo micro (Arabic company for drugs, Egypt), Aspocid (Chemical industries development company, Egypt), Esacard (Multi‐Apex for pharmaceutical industries, Egypt), Aspirin (Memphis company for pharmaceutical and chemical industries, Egypt), were dissolved in 50 mL 0.5 mol L −1 sodium hydroxide solution and heated for an hour, filtered, adjusted to pH 5.0 and finally diluted to 250 mL. The concentration of sal − in these formulations was both potentiometrically and spectrophotometrically 62 determined. The results in Table 3 showed a good agreement between the proposed methods with high recovery percent (97.5–102.2 %).…”

Section: Resultsmentioning

confidence: 99%

Total Synthesis of the Spirocyclic Oxindole Alkaloids Corynoxine, Corynoxine B, Corynoxeine, and Rhynchophylline

et al. 2013

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Racemic total syntheses of four spirocyclic oxindole alkaloids are reported. The general starting material was an N‐2‐butenylated 2‐hydroxytryptamine, which underwent a base‐mediated Mannich spirocyclisation with a functionalised aldehyde to generate the C‐ring. The second key step was a Pd‐catalysed cyclisation of an α‐keto ester enolate (in the original aldehyde) onto an allylic carbonate (in the N‐substituent) to form the D‐ring. The stereoselectivities of the key steps were moderate, but the isomers were readily purified, so that the natural products could be conveniently prepared, three of them for the first time.

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Potentiometric Sensing of Aspirin Metabolite in Human Plasma and Pharmaceutical Preparations Using Co(III)‐complex Based Electrodes: Experimental and Quantum Chemical Calculations

Shehab

Mansour

2016

Electroanalysis

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[a] 1Introduction Salicylate (sal À )i st he main metabolite coming from the hydrolysis of acetylsalicylate and its derivatives,w hich are extensively employed as an analgesic, inflammatory,a ntimicrobial agents,a nd also as ah eart attack protective in severalp harmaceuticalf ormulations [1][2][3].T he diagnosis of poisoning usually involves the determination of sal À in plasma. In general, the sal À level ranges from 30-100 mg/l after usual therapeutic doses, 50-300 mg/l with high doses and 700-1400 mg/l following acuteo verdose.I na ddition, salicylic acid is used as an antiseptic and ap reservative for foods and also applied in synthesis of dyes.T herefore, the determination of sal À and its derivatives in pharmaceuticals and biological samples is vital.S everal methods were reported for analysis of sal À including high performance liquid chromatography [4],f luorometry [5],U V spectrophotometry [6,7],f low injection atomic absorption spectrometry [8],p otentiometric [9-13] and voltammetry [14].M ost of them are tediousa nd time-consuming. In addition, Tr inderr eaction[ 15],a st he most widely used methodf or determination of sal À ,a lways lacks adequate selectivity due to the shortcomings of this reaction.In fact, direct potentiometric methodsb ased on ion-selective electrodes (ISEs) are of simpler design, lower cost, faster time,h igher selectivity,a nd employed for direct measurement of ionic species in the pharmaceutical and biological samples.T he design and synthesis of selective anion receptors that recognize anionic molecules is ag reat challenge for scientists. Theh ydration energy is high for big anions and this makes the receptors hard to sense these ions [16][17][18][19][20][21].Benzimidazole derivatives are also of wide interest because of their diverse biological activityand clinical applications as antihelmintic [22] Abstract:T hree novel poly vinyl chloride( PVC) (A), carbon paste (CP) (B), and coated glassy carbon-MWCNT (CGC) (C)s alicylate (sal, o-nitrophenyloctyl ether as amediator and tridodecylmethylammonium chloride as ac ationic additive were successfully usedf or determination of sal À in human plasma and pharmaceutical formulations.T he sal À -sensors exhibited enhanced sensitivity with slopeo fÀ63.5, À60.5 and À58.9 mV/decade and detection limit of 1.0 10 À5 , 4.0 10 À7 ,a nd 1.0 10 À6 mol L À1 for A-C sensors respectively.Q uantum chemicalc alculations were carried out by HF and DFT/B3LYP methodst oe xplore and investigate the interaction between the receptor and the different anions.T he intermolecular H-bondc reated between the uncoordinated C=Oofsalicylate group and the secondary amino groupi nt he complexi st he key factor of the selectivity of the proposed sensor. Al inear relation is established between the natural charge on the Co center and the value of the binding energy, where the decrease in positive charge is associated by an increase in the anionbinding energy.

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Colorimetric Assay of Aspirin Using Modified Method

Cited by 3 publications

References 2 publications

A Novel Method to Assay Aspirin in Pharmaceutical Formulations by Smartphone Camera-Based Image Scanning Densitometry

A Novel Method to Assay Aspirin in Pharmaceutical Formulations by Smartphone Camera-Based Image Scanning Densitometry

Total Synthesis of the Spirocyclic Oxindole Alkaloids Corynoxine, Corynoxine B, Corynoxeine, and Rhynchophylline

Potentiometric Sensing of Aspirin Metabolite in Human Plasma and Pharmaceutical Preparations Using Co(III)‐complex Based Electrodes: Experimental and Quantum Chemical Calculations

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