Colorimetric aptasensor based on temporally controllable light-stimulated oxidase-mimicking fluorescein for the sensitive detection of exosomes in mild conditions

Zheng, Li-e; Huang, Min; Liu, Yiyang; Bao, Qiufang; Huang, Yuxiu; Ye, Yuhong; Liu, Mengmeng; Sun, Pengming

doi:10.1039/d4ay00561a

Anal. Methods

2024

DOI: 10.1039/d4ay00561a

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Colorimetric aptasensor based on temporally controllable light-stimulated oxidase-mimicking fluorescein for the sensitive detection of exosomes in mild conditions

Li-e Zheng,

Min Huang,

Yiyang Liu

et al.

Abstract: The analysis of exosomes provides important information for rapid and non-invasive screening of tumor. However, sensitive and convenient detection of exosomes still remains technical challenges. Herein, a colorimetric aptasensor for...

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Aptasensors and Advancement in Molecular Recognition Technology

Napit,

Jaysawal,

Chowdhury

et al. 2024

Adv Materials Technologies

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Synthetic oligonucleic acids known as aptamers exhibit remarkable selectivity and affinity for target recognition and binding. Selected via an iterative process known as “selective evolution of ligands by exponential enrichment” (SELEX), aptamers fold into defined 3D conformations to interact with their targets. The incorporation of aptamers as recognition elements has driven notable progress in biosensors, giving rise to the development of aptasensors. Here, the process of aptamer discovery and the development of various types of aptasensors are summarized. The fundamental design principles of aptasensors are elaborated along with the superiority of aptamers compared to antibodies. The various modes employed by aptasensors, such as structure‐switching design, hybridization chain reaction amplification, enzyme‐assisted recycling, and split aptamer design are examined. Further light is shed on the diverse landscape of aptasensors, their adaptability to different analytes aptasensors as well as their potential to propel advancements in modern biosensor technology. As a nucleic acids‐based biosensor platform, aptasensors poise to become a next generation of sensitive and cost‐effective technology to shape the future of molecular recognition in biosensing.

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Aptasensors and Advancement in Molecular Recognition Technology

Napit,

Jaysawal,

Chowdhury

et al. 2024

Adv Materials Technologies

View full text Add to dashboard Cite

show abstract

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Colorimetric aptasensor based on temporally controllable light-stimulated oxidase-mimicking fluorescein for the sensitive detection of exosomes in mild conditions

Abstract: The analysis of exosomes provides important information for rapid and non-invasive screening of tumor. However, sensitive and convenient detection of exosomes still remains technical challenges. Herein, a colorimetric aptasensor for...

Cited by 1 publication

References 53 publications

Aptasensors and Advancement in Molecular Recognition Technology

Aptasensors and Advancement in Molecular Recognition Technology

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