Colorimetric and fluorescent detection of synthetic cathinones in oral fluid with <i>meso</i>-aryl BODIPYs and Cu(<scp>ii</scp>)

Hernández-Contreras, Jordi; Parra, Margarita; Gil, Salvador; Costero, Ana M.; Arroyo, Pau; Sancenón, Félix; Martínez‐Máñez, Ramón; Sáez, José A.; Gaviña, Pablo

doi:10.1039/d2ra05188e

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…While the determination of synthetic cathinones in oral fluid by gas chromatography (GC) or liquid chromatography (LC) coupled to mass spectrometry systems (GC-MS and LC-MS or LC-MS/MS) is reported in the literature [15][16][17][18][19][20][21][22][23][24][25][26], synthetic cathinones in sweat specimens remain scarcely explored [27]. Moreover, no determination of synthetic cathinones by GC-MS/MS is reported in the international literature.…”

Section: Introductionmentioning

confidence: 99%

GC–MS/MS Determination of Synthetic Cathinones: 4-Chloromethcathinone, N-Ethyl Pentedrone, and N-Ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study

Nuñez-Montero,

Lombroni,

Maida

et al. 2023

IJMS

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This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its feasibility in determining human oral fluid concentrations and pharmacokinetics following the administration of 100 mg of 4-CMC orally and 30 mg of NEP and NEH intranasally. A total of 48 oral fluid and 12 sweat samples were collected from six consumers. After the addition of 5 μL of methylone-d3 and 200 μL of 0.5 M ammonium hydrogen carbonate, an L/L extraction was carried out using ethyl acetate. The samples, dried under a nitrogen flow, were then derivatized with pentafluoropropionic anhydride and dried again. One microliter of the sample reconstituted in 50 μL of ethyl acetate was injected into GC-MS/MS. The method was fully validated according to international guidelines. Our results showed how, in oral fluid, the two cathinones taken intranasally were absorbed very rapidly, within the first hour, when compared with the 4-CMC which reached its maximum concentration peak in the first three hours. We observed that these cathinones were excreted in sweat in an amount equivalent to approximately 0.3% of the administered dose for 4-CMC and NEP. The total NEH excreted in sweat 4 h after administration was approximately 0.2% of the administered dose. Our results provide, for the first time, preliminary information about the disposition of these synthetic cathinones in the consumers’ oral fluid and sweat after controlled administration.

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Section: Introductionmentioning

confidence: 99%

GC–MS/MS Determination of Synthetic Cathinones: 4-Chloromethcathinone, N-Ethyl Pentedrone, and N-Ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study

Nuñez-Montero,

Lombroni,

Maida

et al. 2023

IJMS

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Optical detection of scopolamine and ketamine with a BODIPY-Phen conjugate and Cu(II)

Hernández-Contreras,

Madrigal,

Arroyo

et al. 2024

Dyes and Pigments

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Advancements in colorimetric and fluorescent-based sensing approaches for point-of-care testing in forensic sample analysis

Rasheed,

Ikram,

Ahmad

et al. 2024

Microchemical Journal

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Colorimetric and fluorescent detection of synthetic cathinones in oral fluid with meso-aryl BODIPYs and Cu(ii)

Abstract: Colorimetric and fluorescent detection of synthetic cathinones in oral fluid by a 1 : 1 mixture of a BODIPY dye and Cu(ii).

Cited by 3 publications

References 22 publications

GC–MS/MS Determination of Synthetic Cathinones: 4-Chloromethcathinone, N-Ethyl Pentedrone, and N-Ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study

GC–MS/MS Determination of Synthetic Cathinones: 4-Chloromethcathinone, N-Ethyl Pentedrone, and N-Ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study

Optical detection of scopolamine and ketamine with a BODIPY-Phen conjugate and Cu(II)

Advancements in colorimetric and fluorescent-based sensing approaches for point-of-care testing in forensic sample analysis

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