Colored Cosmetic Contact Lenses

Singh, Shwetambari; Satani, Dipali; Patel, A.; Vhankade, Ravinder

doi:10.1097/ico.0b013e31823cbe9c

Cited by 62 publications

(29 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, four P. aeruginosa clinical isolates from human ocular surface infections (keratitis and conjunctivitis) and with varying degrees of resistance to commonly used antibiotics were included for comparison, as well as other three bacterial strains belonging to the Staphylococcus genus (i.e. S. aureus, S. epidermidis, S. hominis ) which are relevant not only for cornea, but also for conjunctival infections [44, 45]. Importantly, Esc-1a(1-21)NH 2 was found to be active against the selected clinical isolates with MIC values measured in the range of 2–8 μM for P. aeruginosa strains compared with a MIC of 1 μM or 8 μM for S. hominis or S. epidermidis , respectively.…”

Section: Resultsmentioning

confidence: 99%

Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis

Kolar

Luca

Baidouri

et al. 2014

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Pseudomonas aeruginosa is the primary bacterial pathogen causing contact lens related keratitis. Available ophthalmic agents have reduced efficacy and antimicrobial peptides (AMPs) hold promise as future antibiotics. Here we investigated the in vitro and in vivo anti-Pseudomonal activity of esculentin-1a(1-21)-NH2, derived from a frog skin AMP. The data revealed a minimum inhibitory concentration between 2 and 16 μM against reference strains or drug-resistant clinical isolates of P. aeruginosa without showing toxicity to human corneal epithelial cells up to 50 μM. At 1 μM the peptide rapidly killed bacterial cells and this activity was fully retained in 150 mM sodium chloride and 70% (v/v) human basal tears, particularly against the virulent ATCC 19660 strain. Furthermore, its dropwise administration at 40 μM to the ocular surface in a murine model of P. aeruginosa keratitis (three times daily, for 5 days post-infection) resulted in a significant reduction of infection. The mean clinical score was 2.89 ± 0.26 compared to 3.92 ± 0.08 for the vehicle control. In addition, the corneal level of viable bacteria in the peptide treated animals was significantly lower with a difference of 4 log10 colony counts, compared to 7.7 log10 cells recovered in the control. In parallel, recruitment of inflammatory cells was reduced by half compared to that found in the untreated eyes. Similar results were obtained when esculentin-1a(1-21)NH2 was applied prior to induction of keratitis. Overall, our findings highlight esculentin-1a(1-21)NH2 as an attractive candidate for the development of novel topical pharmaceuticals against Pseudomonas keratitis.

show abstract

Section: Resultsmentioning

confidence: 99%

Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis

Kolar

Luca

Baidouri

et al. 2014

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…Risk-taking and noncompliant behavior were also noted by the authors. More recently, Singh et al reported 13 cases of complications in patients wearing cosmetically tinted contact lenses 8. Much like the cases reported by Steinemann et al, none of the patients were aware of or instructed about proper lens handling techniques prior to use, and poor compliance was a common factor in all cases.…”

Section: Discussionmentioning

confidence: 98%

“…Despite the popularity of cosmetically tinted lenses, there have been negative reports regarding safety in the literature 5–10. Compliance-related reports in the literature all have in common patient histories of receiving the contact lenses without a prescription, with no or limited care, limited handling and wearing instructions, and no follow-up examinations 6,8–10. Complications related to compliance are not limited to cosmetically tinted contact lenses.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of studies on cosmetically tinted soft contact lenses

Rah¹,

Schäfer²,

Zhang³

et al. 2013

OPTH

View full text Add to dashboard Cite

BackgroundConcerns regarding the safety of cosmetically tinted contact lenses have been reported in the literature. The purpose of this paper is to evaluate the safety of cosmetically tinted contact lenses in a large number of patients across six clinical trials that varied from 1 week to 3 months in duration.MethodsLenses tested included: Naturelle limbal ring daily disposable, Lacelle limbal ring daily disposable, Lacelle colored cosmetic daily disposable, Lacelle limbal ring planned replacement at 2 weeks, and Alamode traditional/annual colored cosmetic lens. The primary safety outcome was slit-lamp examination, including epithelial edema, epithelial microcysts, corneal staining, bulbar injection, limbal injection, upper lid tarsal conjunctival abnormalities, corneal neovascularization, and corneal infiltrates. High contrast logMAR visual acuity with lenses, and lens wearing time, movement, and centration, are also presented.ResultsA total of 871 subjects (1,742 eyes) and 23 clinical investigators participated in the six studies, with an average completion rate of 96.4% across all studies. The mean age of the patients was 26.8 ± 6.6 years, and 86.7% of participants were female. The total number of slit-lamp examinations across the six studies was 2,456 visits by eye (1,228 visits by patient). There were no slit-lamp signs > grade 2 for any finding, with the exception of corneal staining in one study. In this study, grade 3 corneal staining was noted in one eye (0.1%) at follow-up visit 1 and four (0.6%) of all eligible dispensed eyes at follow-up visit 2, with no eyes requiring medical treatment. No adverse events were reported during any of the trials.ConclusionThe cosmetically tinted lenses evaluated in this meta-analysis appear to be safe when properly prescribed by an eye care professional and used in a compliant manner.

show abstract

“…ese lens materials are composed of copolymers of HEMA and other hydrophilic or lipophilic monomers such as Nvinyl pyrrolidone (NVP) and methacrylates, the diversity of which contributes to the wide range of water contents of both ionic and nonionic lens materials [1,2]. Among these contact lenses, cosmetic-type soft lenses containing colored patterns are rapidly gaining market share over the conventional clear-type soft lenses among young people, especially in Asian markets [3,4]. Cosmetic contact lenses are used to change or enhance the iris color to give a softer look through complex print patterns or a pigmented ring pattern that overlap with the limbal ring of the iris [5].…”

Section: Introductionmentioning

confidence: 99%

ToF-SIMS and AFM Characterization of Brown Cosmetic Contact Lenses: From Structural Analysis to the Identification of Pigments

Kim

Lee

Jang

et al. 2020

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

Over the years, soft contact lenses for vision correction and cosmetic and therapeutic purposes have been greatly improved. For cosmetic contact lenses, the pigments need to be nontoxic, and the position of the pigment layer is particularly important because of the risks posed by pigment elution and the roughness of the lens surface. In this paper, we characterized the properties of brown cosmetic contact lenses made by three different manufacturers using surface analytical techniques. The surface topographies of the noncolored and colored parts were obtained by atomic force microscopy (AFM), and the position and composition of the pigment layer were determined by analyzing the cross section of the contact lenses using scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX). The influence of pigment location on surface roughness was also examined. In addition, to find the method of the evaluation for the risk of surface elution of the pigments in the colored parts, the mass spectra and ion images of the surfaces were obtained by time-of-flight secondary ion mass spectrometry (ToF-SIMS) with a new sample preparation. From the ToF-SIMS spectra, we observed specific fragment ions of the poly(hydroxyethyl methacrylate) (PHEMA) polymer and found differences in the composition of the pigment layer depending on the manufacturers. The cross-sectioned image and 3D chemical characterizations of metallic and specific ions in the brown cosmetic contact lenses clearly indicated the spatial distribution and location of the pigment layer that can be used for the evaluation of pigment elution.

show abstract

Colored Cosmetic Contact Lenses

Abstract: Over-the-counter use of decorative lenses as a cosmetic aid is rapidly increasing. Easy and unmonitored availability of these cosmetic lenses is followed by severe sight-threatening complications in young emmetropic individuals.

Cited by 62 publications

References 17 publications

Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis

Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis

A meta-analysis of studies on cosmetically tinted soft contact lenses

ToF-SIMS and AFM Characterization of Brown Cosmetic Contact Lenses: From Structural Analysis to the Identification of Pigments

Contact Info

Product

Resources

About