Colorectal visceral perception in diverticular disease

Abstract

Background and aims: The pathogenesis of asymptomatic diverticular disease (ADD) and symptomatic uncomplicated diverticular disease (SUDD) has not been elucidated. The aim of our study was to assess whether altered visceral perception or abnormal compliance of the colorectal wall play a role in these clinical entities. Methods: Ten ADD patients, 11 SUDD patients, and nine healthy controls were studied. Using a dual barostat device, sensations were scored and compliance curves obtained using stepwise intermittent isobaric distensions of the rectum and sigmoid, before and after a liquid meal. In addition, the colonic response to eating was assessed by monitoring the volumes of both barostat bags at operating pressure before and after the meal. Results: In the rectum, perception was increased in the SUDD group compared with controls (p = 0.010) and the ADD group (p = 0.030). Rectal compliance curves were not different between the groups. In the sigmoid colon, perception in the pre-and postprandial periods was increased in SUDD compared with controls (p = 0.018) but not when compared with ADD. Sigmoid volume-pressure curves had comparable slopes (compliance) in all groups but were shifted downwards in SUDD compared with ADD in the preprandial period (p = 0.026). The colonic response to eating (decrease in intrabag volume) was similar in all three groups, both in the rectum and sigmoid. Conclusion: Symptomatic but not asymptomatic uncomplicated diverticular disease is associated with heightened perception of distension, not only in the diverticula bearing sigmoid, but also in the unaffected rectum. This hyperperception is not due to altered wall compliance.

Diarrhea-Predominant Irritable Bowel Syndrome Is Associated With Diverticular Disease: A Population-Based Study

“…Visceral sensation may also be altered in patients with colonic diverticular disease; a heightened perception to mechanical distension in the diverticula bearing sigmoid and in the unaffected rectum was noted in patients with symptomatic, uncomplicated diverticular disease (15). Similar pathophysiological findings have been reported in IBS (16).…”

Colonic Diverticular Disease: Pathophysiology and Clinical Picture

“…One study showed heightened visceral perception of rectosigmoid perception (and not only in the area with diverticula), not due to altered compliance of the bowel wall [54]. This situation of hyperperception resembles IBS.…”

Enfermedad diverticular: mitos y realidades

“…Estudios recientes han planteado que la incidencia de DA podría ser < 5% 8 . Es importante mencionar que pacientes jóvenes presentarían una mayor incidencia de diverticulitis por año de vida en comparación a población de mayor edad, cuestionando la percepción tradicional acerca de la frecuencia de progresión de diverticulosis a DA 9 .…”

“…Un estudio menciona que en pacientes sin antecedentes de patología intestinal funcional, el desarrollo de SII era 4,7 veces más probable tras un episodio de DA 37 . Pacientes con EDSNC presentarían mayor percepción de dolor a la distensión, no solo del sigmoides, sino también del recto, confirmando la hipersensibilidad visceral 9 . Aumento de neuropép-tidos y alteraciones en la inervación entérica han sido sugeridos como mecanismos relacionados con la hipersensibilidad 38 .…”