Colorectal tumor screening in women with a past history of breast, uterine, or ovarian malignancies

Rozen, Paul; Fireman, Zvi; Figer, Arié; Ron, Elaine

doi:10.1002/1097-0142(19860315)57:6<1235::aid-cncr2820570629>3.0.co;2-i

Cited by 33 publications

(10 citation statements)

References 16 publications

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“…It has been repeatedly reported that there is an increased risk for the co‐occurrence of breast cancer and GI malignancies in the same women (1,6). However, the results of the present study, which is a single institution group of patients with breast cancer, demonstrated slightly different results.…”

Section: Discussionmentioning

confidence: 99%

“…Contralateral breast cancer accounts for 40–50% of all second tumors in women with breast cancer (1), a risk that increases to approximately 40% at 10 years in women with BRCA‐1 / ‐2 gene mutations (5). Breast cancer has been reported to also confer a greater risk for gastrointestinal (GI) cancer (1,6). The relative risk of GI malignancies has been reported to be 1.2 in breast cancer patients (1), and even higher in the carriers of mutations in BRCA‐1 or BRCA‐2 genes (7).…”

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confidence: 99%

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Gastrointestinal Carcinomas Occurring in Breast Cancer Patients

Pappo¹,

Stahl-Kent²,

Sandbank³

et al. 2006

Breast Journal

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Breast cancer patients are reported to have a higher rate of second primary malignancies. We retrospectively reviewed the coexistence of breast and gastrointestinal (GI) tumors in the same patients and the characteristics of the tumors. The charts of all patients more than 35 years of age who were diagnosed with breast cancer and hospitalized for various reasons between 1985 and 2003 were reviewed and those who also had a diagnosis of GI malignancy were then selected. Age and tumor characteristics were evaluated. Out of all the patients, 2,650 had a diagnosis of breast cancer, while 40 (1.5%) also had GI malignancies. Among a comparable group of 70,784 consecutive female patients without breast cancer, 1,292 patients (1.8%) had a diagnosis of GI malignancy. The location of GI tumors in patients with both tumors was as follows: stomach, 6 (15%); right colon, 8 (20%); left colon, 7 (17.5%); sigma, 9 (22.5%); and rectum, 10 (25%). Seventeen of the patients (51.5%) had Dukes C and D tumors, 14 (42.5%) Dukes B, and 2 (6%) Dukes A or in situ. The stage of the others was not identified. The mean age at diagnosis of breast cancer was 68.5 years (range 48-88 years). In 23 (57.5%), GI cancer was diagnosed after breast cancer, in 7 (17.5%) it was diagnosed within 3 months of diagnosing breast cancer, and in 8 (20%) it was diagnosed prior to the diagnosis of breast cancer. Five patients suffered from an additional primary cancer: three endometrial, one lung, one esophageal, and one patient had two additional tumors in the endometrium and thyroid. We conclude that the rate of GI malignancies in breast cancer patients is slightly lower than in comparable patients without breast cancer. GI malignancies tend to be diagnosed later and are found more often in the distal colon.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Gastrointestinal Carcinomas Occurring in Breast Cancer Patients

Pappo¹,

Stahl-Kent²,

Sandbank³

et al. 2006

Breast Journal

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“…In patients with prior histories of breast, uterine or ovarian lesions, screening with fecal occult blood, flexible s1gmoidoscopy and colonoscopy when appropriate was reported by Rozen et al (23 ). A total of 183 patients were compared with 252 age-and ethnically matched controls.…”

Section: Recent Screening Studiesmentioning

confidence: 99%

Screening by Colonoscopy - Has the Time Arrived?

Hunt

1990

Canadian Journal of Gastroenterology

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Colorectal cancer mortality may be reduced by several screening strategies -mathematical modelling suggests that mortality may be reduced by one-third in patients over the age of 40 years who undergo annual fecal occult blood testing. Similar modelling suggests that either colonoscopy or barium enema may reduce mortality by up to 85%. This paper reviews the evidence for different screening approaches for colorectal cancer, and identifies high risk groups in whom full colonoscopy has been studied. These studies include patients with first degree relatives with colorectal cancer, family cancer syndrome, prior breast, uterine or ovarian lesions, and follow-up for prior adenomatous polyps or cancer. The role of colonoscopy in the surveillance of patients with chronic total ulcerative colitis for dysplasia is also reviewed. The implications for patient management and possible clinical strategies are discussed. Can J Gastroenterol 1990;4(9):527-432 Depistage par colonoscopie -Le moment est~il arrive? RESUME: Plusieurs strategies de depistage permettent de reduire la morcalite pour cancer recrn-colique -les modeles mathematiques suggerent que la mortalite peut etre diminuee d'un tiers chez les patients ages de plus de 40 ans qui subissent annuellement des tests de depistage du sang occultc clans lcs selles. Des modeles similaires suggerent que la colonoscopie ou le lavement baryte permet une reduction pouvant atteindre 85 %. Le present article examine les diverses methodes de depistage du cancer recto-colique et definit les groupes a haut risque pour qui la colonoscopie complete a ete etudiee (patients dont un parent proche est porteur de cancer recto-colique, syndrome de cancer familial, antecedents de cancer du sein, de !'uterus ou des ovaires; suivi des patients ayant eu des antecedents de polypes adenomateux ou de cancer). La surveillance colonoscopique a la recherche de dysplasie des cas de colite ulcereuse chronique a forme pancolique est egalement examinee. Les implications de la prise en charge et les strategies cliniques possibles sont egalement proposees.

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“…However, there is little information upon which to estimate the expected yield of screening among persons with this risk factor. Rozen et a1 [17] have reported on screening 183 women with histories of gynecologic cancer. Neoplastic conditions were three times as prevalent among these women compared to a control group.…”

Section: Prescreening By Risk Factorsmentioning

confidence: 99%

The current status of early detection and screening for colorectal cancer

Mettlin

Cummings

1986

Seminars in Surgical Oncology

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There are several approaches to the early detection of colorectal cancer that currently are in use in various segments of the health care system. Herein, the status of cancer control research regarding symptom and risk factor assessment, sigmoidoscopy and colonoscopy, double contrast barium enema, and fecal occult blood testing is reviewed. In addition to the different technologies of early cancer detection, there are different models of disease control intervention. These include the routine clinical activities of primary care providers as well as programmatic screening of mass populations. The currently available techniques for early colorectal cancer detection appear better suited for existing patient care settings than for programs outside the direct supervision and follow-up of the health professional.

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Colorectal tumor screening in women with a past history of breast, uterine, or ovarian malignancies

Cited by 33 publications

References 16 publications

Gastrointestinal Carcinomas Occurring in Breast Cancer Patients

Gastrointestinal Carcinomas Occurring in Breast Cancer Patients

Screening by Colonoscopy - Has the Time Arrived?

The current status of early detection and screening for colorectal cancer

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