Colorectal Screening Program in Northern Portugal: First Findings

Abstract

Introduction: In Portugal, a colorectal cancer screening program based on faecal immunochemical test followed by colonoscopy was shown to be cost-effective for individuals between 50 and 74 years old. We report the first findings of the implementation of a population-based program In Northern Portugal.Material and Methods: In the pilot phase, eligible subjects were allocated either to a direct mailing invitation or to primary care centers. In the first year of program implementation, we assessed the uptake rate, the faecal immunochemical test -positivity rate, the diagnostic yield of advanced neoplasia, and the quality parameters for post-faecal immunochemical test + colonoscopy.Results: We invited 100 501 eligible subjects (49% male with a median age of 55 years). Of these, 5228 participated in the pilot phase and 95 273 participated in the first year of the program. In the first year of the program, the adherence was 29%, with a positivity rate of 5% and a 60% compliance to colonoscopy. The faecal immunochemical test-detection rate of advanced neoplasia was 0.35/1000 subjects, and the positive predictive value at post- faecal immunochemical test + colonoscopy was 44% and 2% for advanced adenoma and invasive cancer, respectively. No major adverse events were reported after colonoscopy.Discussion: The suboptimal adherence to faecal immunochemical test and post-faecal immunochemical test + colonoscopy remains the most urgent step to be addressed.Conclusion: A centralized invitation system based on direct mailing was feasible and both colonoscopy quality and diagnostic yield were adequate antecipating the success of the programme.

Potential global loss of life expected due to COVID-19 disruptions to organised colorectal cancer screening

“… 50–69 Biennial 2 62.8% (2014) 54 Portugal, Norte 39.4 13. 50–69 Biennial 2 29.% (2019) 71 Singapore 33.0 16.2 50− f Annual 1 27.3% (2016) 72 , 73 Slovakia 43.9 21. 50–74 Biennial 3 34.0% (2019) 74 Slovenia 39.6 11.7 50–74 Biennial 3 50.5% (2012) 60 South Korea 27.2 7.8 50–80 Annual 1 19.1% (2019) 75 Spain k 35.8 11.5 50–69 Biennial 2 52.9% (2019) 76 , 77 Sweden 27.8 10.8 60–69 Biennial 4 68.4% (2016) 51 , 78 Switzerland 22.3 7.5 50–69 Biennial...…”

Zircon U–Pb Dating and Lu–Hf Isotopic Composition of Some Granite Intrusions in Northern and Central Portugal: Constraints on the Emplacement Age and Nature of the Source Rocks

“…D 3 folds were dated at 315-305 Ma [35,51]. A new extensional event E 2 (305-280 Ma [50]) occurred after the D 3 deformation period, with the development of a set of conjugate strike-slip faults (NNW-SSE, NNE-SSW and ENE-WSW) in higher crustal levels, under greenschist facies retrograde conditions [46,[52][53][54][55]. However, in the lower crustal levels, the high temperatures could have persisted as the result of the high thermal gradients from the D 2 deformation period and the intrusion of early synkinematic granitoids [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49].…”

Szűrő kolonoszkópos vizsgálatok hatékonyságának és biztonságosságának értékelése a Szegedi Tudományegyetemen és a Bács-Kiskun Vármegyei Oktatókórházban 2019 és 2022 között

“…A szűrés kimeneteli mutatói messze alatta maradnak a magyar szűrőprogram eredményeinek, ami az első lépcső során alkalmazott FOBT-vel történő előszűréssel magyarázható. A kétlépcsős programokban az adenomafelismerési arány 33,5-51,5% között változik, míg a malignitásé 2,16-9,0% között [11][12][13][14]. A United States Multisociety Task Force on Colorectal Cancer irányelve a FOBT nem negatív eseteiben az adenomafelismerési arány elvárt minimumértékét férfiaknál 45%-ban, nőknél pedig 35%-ban határozta meg [15].…”