Colorectal Considerations in Pediatric Patients

Gourlay, David M.

doi:10.1016/j.suc.2012.09.017

Cited by 5 publications

(11 citation statements)

References 57 publications

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“…The lack of adherence to the external anal sphincter prevented a complete obstruction. Atretic conditions have been experimentally induced with occlusion of blood supply to the intestinal segment, but the pathogenesis has also been postulated to be more complex (van der Gaag and Tibboel ; Gourlay ). In horses, atresia of the colon has been reported to occur twice as often as anal or rectal atresia (Benamou et al .…”

Section: Discussionmentioning

confidence: 99%

“…Atresia ani is a congenital anomaly where the anal membrane fails to break down, preventing passage of faeces, and has been reported in domestic animals and man (Dreyfuss and Tulleners ; Benamou et al . ; Gourlay ). In normal development, intestinal epithelium proliferates during early gestation leading to temporary luminal obstruction, which then regresses to maintain patency throughout the intestine.…”

Section: Introductionmentioning

confidence: 99%

“…Atresia ani affects both horses and cattle, but horses often have concurrent urogenital abnormalities (Dreyfuss and Tulleners ; Benamou et al . ; Gourlay ). Hypospadias is a developmental abnormality where the urethral meatus does not end at the tip of the glans penis (Brink and Schumacher ), and is classified based upon the location of the urethral defect: perineal, scrotal, penoscrotal, penile, subcoronal or glanular.…”

Section: Introductionmentioning

confidence: 99%

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Surgical management of atresia ani and perineal hypospadias in a miniature donkey foal

Nelson

Ferris

McCue

et al. 2015

Equine Veterinary Education

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A 3-week-old miniature donkey was evaluated for tenesmus and constipation resulting from atresia ani. The foal was also diagnosed with hypospadias extending from its perineum to the glans penis and caudoventral penile deviation. A common opening on the perineum allowed faeces and urine to be excreted together, preventing complete intestinal obstruction. Surgical correction of the atresia ani was performed, along with resection of the incomplete urethra, nonfunctional penis and testes. The anal and perineal reconstruction procedures resolved the miniature donkey's difficulty in defaecation. The anourethral portion of the repair healed, but the anoperineal portion dehisced and healed by second intention. The client was satisfied with the outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical management of atresia ani and perineal hypospadias in a miniature donkey foal

Nelson

Ferris

McCue

et al. 2015

Equine Veterinary Education

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“…As a result of the neural crest cells failing to adequately develop and migrate proximally, segments of bowel extending from the rectum to the small intestine may be affected. 1 The involved segment is most often limited to the rectosigmoid region in 80% of patients, with male patients affected 3 to 4 times more often than female patients. Most cases occur sporadically, but nearly 30% are associated with chromosomal or congenital anomalies such as Down syndrome or congenital central hypoventilation syndrome.…”

Section: Gastrointestinal Complications In Two Neonatesmentioning

confidence: 99%

Gastrointestinal Complications in Two Neonates

Basuray¹,

Swick²,

Splinter³

2021

Consultant

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“…Δίλαη δπλαηφλ λα δηαηεξεζνχλ ππνιείκκαηα ηνπ νκθαιεληεξηθνχ πφξνπ. πλήζε είλαη ηα εηιετθά εθθνιπψκαηα, πάλησο κφλν ιίγα απφ απηά θιεγκαίλνπλ θαη πξνθαινχλ πφλν [6][7][8][9][10] .…”

Section: γδνηκο μδρο ανασομηκζ σοτ παυδο δνσδροτ σοηυδηα δμβρτολογηαunclassified

Μελέτη Της Επίδρασης Της Βακτηριακής Αλλόθεσης Στην Μετεγχειρητική Πορεία Και Την Απώτερη Πρόγνωση Ασθενών Με Καρκίνο Του Παχέος Εντέρου

Κεραμιδάρης¹

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Introduction: Bacterial translocation is defined as the passage of live bacteria or theirconstituents from the gastrointestinal tract in extraintestinal sites. The importance ofbacterial translocation in colorectal cancer patients remains controversial. This studyinvestigates the association of bacterial translocation with long-term prognosis ofpatients with colorectal cancer. Additionally this study examines the predictive valueof serum procalcitonin measurement in patients with colorectal cancer.Material and Methods: This prospective study enrolled 54 consecutive patients withhistologically confirmed colorectal cancer. After receipt of patient's consent patientdemographics and clinical and pathological features of the disease were documented.Moreover, the value of serum procalcitonin, WBC, ESR and CRP were measured in ablood sample. In the operating room, immediately after laparotomy and before anysurgical manipulation irrigation of the peritoneal cavity with 100cc N / S 0.9% wasperformed and the washing was collected and sent for culture to determine thepossible presence of bacteria.Postoperatively, patients were followed for 60 days, during which all postoperativecomplications were recorded. Furthermore, long term overall survival and diseasefreesurvival were recorded.All statistical analyzes were performed with the statistical package SPSS. The p-value<0.05 was determined as statistically significant level of difference but we alsorecorded marginally significant statistical differences (0.05 <P <0.1).Results: The study included 32 men and 22 women with a mean age of 71 ± 11.02years . The median duration of hospitalization was 11 days , 35 % had complicationsduring hospitalization and 4% resulted in death. The cultures of the peritoneal lavagefluid was positive in 11% of patients with isolation Gram positive in 67% and Gramnegative pathogenic microorganism in 33%. Statistical analysis revealed no significant correlation between the culture of the peritoneal fluid and patientcharacteristics, clinical course, characteristics of the tumors and the levels of whiteblood cells , ESR , CRP, PCT and CEAThe analysis showed a significant positive correlation between the PCT andinflammatory markers (WBC, CRP, TKE) and the tumor marker CEA (p <0.05).Patients with distant metastases had significantly higher levels of PCT (0.074compared to 0.043 mg / L) compared to patients without metastases (p <0.05).Marginal statistical significance was found between the PCT and the degree ofdifferentiation (p = 0.09) The median follow up was 46 [ 22, 55 ] months . Duringfollow-up of patients 45.5 % had disease recurrence and 43.6 % died.The statistical analysis did not show the presence of significant correlation betweenthe result of the culture of the peritoneal fluid, and the overall and disease-freesurvival. The Kaplan-Meier survival showed a trend towards a shorter overallsurvival in patients with elevated levels of PCT No statistically significant correlationbetween the levels PCT and disease-free survival of patients was foundConclusion: The results of this study showed that bacterial translocation is relativelyfrequent in colorectal cancer and Procalcitonin is a useful biomarker for theinvestigation of patients with colorectal cancer. The clinical significance of bacterialtranslocation in patients with colorectal cancer is minimal as is not correlated withprognosis.

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Colorectal Considerations in Pediatric Patients

Cited by 5 publications

References 57 publications

Surgical management of atresia ani and perineal hypospadias in a miniature donkey foal

Surgical management of atresia ani and perineal hypospadias in a miniature donkey foal

Gastrointestinal Complications in Two Neonates

Μελέτη Της Επίδρασης Της Βακτηριακής Αλλόθεσης Στην Μετεγχειρητική Πορεία Και Την Απώτερη Πρόγνωση Ασθενών Με Καρκίνο Του Παχέος Εντέρου

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