Colorectal carcinoma in gharbiah district, Egypt: Comparison between the elderly and non-elderly

Abstract

<p class="a"><strong>Objective:</strong> This work was conducted to study colorectal carcinoma (CRC) in Gharbiah district, Egypt and to verify the effect of age on the treatments and their outcomes.<span><br /> </span><strong>Methods:</strong> <span>B</span>etween 2000 and 2002, 293 cases with CRC were identified in the Gharbiah population based cancer registry (GPBCR); 159 of whom were treated at Tanta Cancer Center (TCC). Patients were grouped into elderly and non-elderly (<span>≥</span> and < 65 years, respectively).<span><br /> </span><strong>Results:</strong> CRC was the 6th cancer in Egypt, representing 4% of the total cancers and 53% of GIT cancers. The median age was 53 years with male predominance. Colon cancers were more common than rectal cancers. Most patients had tumors that were localized, low grade and adenocarcinoma (AC). Constipation, abdominal pains and bleeding per rectum were the commonest complaints. Surgery, radiotherapy and chemotherapy were adopted in 84, 28 and 72% of patients,<span> </span>respectively. The median OS and PFS were 23 and 25 months (95%CI: 17-29 and 11.8-18.2), respectively. Compared to non-elderly, elderly patients were more likely to have rectal tumors, non-AC histology, non-metastatic disease; more comorbidities were less likely to receive chemotherapy particularly in the adjuvant setting (<em><span>P</span></em>< 0.05 for all). The OS and PFS of elderly patients were not statistically different from the non-elderly.<span><br /> </span><strong>Conclusions:</strong> Within the limits of this retrospective trial, elderly patients with CRC tend to have more rectal and non-metastatic cancers. They were more likely to have comorbidities and less likely to receive chemotherapy. However, the OS and DFS were comparable to non-elderly.</p><p><strong><br /></strong></p&gt

Evaluation of microRNAs-29a, 92a and 145 in colorectal carcinoma as candidate diagnostic markers: An Egyptian pilot study

“…Also, CRC was mainly moderately differentiated (56%), and more commonly and comparably presented in stages II and III (24% and 20%, respectively), and mostly localized (≥ 80%). This was in concordance with many studies [24,27,28], and Zeeneldin et al, except for the higher incidence of metastasis among young patients [18].…”

“…This is a common CRC demographic feature in Egypt [17,18,24]. Also, most of positive FOBT (92.8%) had CRC, which confirms its reliability in diagnosis [25,26].…”

“…This agreed with another Egyptian studies [17,18,24]. On the contrary, Khafagy et al found the rectum the commonest site affected [27].…”

“…CRC was the 6th cancer in Egypt, representing 4% of the total cancers and 53% of GIT cancers [18]. miRNAs have been linked to CRC initiation, development, and progress, diagnosis, prognosis, and also therapy [19,20], for their function as non-coding tumour suppressors and oncogenes, as well as their their interference with apoptosis [6].…”

The expression profiling of serum miR-92a, miR-375, and miR-760 in colorectal cancer: An Egyptian study

“…Patients' diagnosis and cancer staging were based on the colonoscopic findings, abdominal radio-imaging, pathological findings, and clinical decisions. Based on these findings, patients were classified according to the American Joint Committee on Cancer (AJCC) 2010 into three stages: 4. In addition to 27 control subjects who were selected as apparently healthy volunteers without gastrointestinal symptoms, chronic disease history, cancer, and family history of CRC.…”