Colorectal Carcinoma in Children and Adolescents in Low Middle Income Countries: Single Center Experience

Zekri, Wael; Ahmed, Soha; Elhemaly, Ahmed; Ahmed, Gehad; Zaki, Eman M.; Elkinaee, Naglaa; Elnashar, Amr; Adly, Marwan H; Younes, Alaa; Hamoda, Asmaa

doi:10.11648/j.crj.20210901.12

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…It is the third most common cancer in adults after lung cancer and breast cancer worldwide. Its incidence peaks at age 55-60 years (19) . In Egypt, CRC ranked the sixth, representing about 4% of total cancers in both sexes (20) .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Immunohistochemical Expression of CD44 and Osteopontin in Colorectal Carcinoma and colorectal adenoma

El-maksoud

elokda

Zidan

et al. 2023

Preprint

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Background Colorectal cancer (CRC) is a foremost global health concern and remains one of the major causes of cancer-related morbidity and mortality. It is the third most common cancer in adults after lung cancer and breast cancer worldwide. The theory that cancer originates from a subpopulation of tumor cells, named cancer stem cells (CSC), they have important role of CSC in the initiation and maintenance of the tumor, as well as invasion, metastasis and therapeutic resistance. Among CSC markers, CD44 and OPN are two of the most investigated colorectal CSC markers and their proteins are introduced as the subpopulation with a greater tumorigenicity. This study aiming assessing the immunohistochemical expression of CD44 & OPN in colorectal adenomas & CRCs. And their relation between immunohistochemical expression of CD44 & OPN with tumor differentiation (grading), lympho-vascular invasion, perineural invasion, desmoplasia and TNM stage. Methods this is a retrospective descriptive study that included Sixty paraffin embedded blocks from the pathology laboratory, Suez Canal University Hospital. Paraffin blocks included (14 cases of colorectal carcinoma and 18 cases of colorectal adenoma). paraffin blocks reviewed for clinicopathological prognostic factors and stained by CD44 & OPN, monoclonal antibodies by immunohistochemical method. Results The CD44 protein was overexpressed in 80% of CRC, while was positive (44.4%) in adenoma this difference was statistically significant. Also, in this study the difference between the expression OPN in CRC and adenomas was statistically insignificant. Conclusions CD 44 is highly expressed in large number of CRC (80 of tumors). It is also significantly more expressed in CRC than in adenomas, suggesting a role of CD 44 in CRC tumorigenesis and progression of adenomas into carcinomas. Our study also associated CD 44 overexpression with both late TNM stage and lympho-vascular invasion.

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Section: Discussionmentioning

confidence: 99%

Assessment of Immunohistochemical Expression of CD44 and Osteopontin in Colorectal Carcinoma and colorectal adenoma

El-maksoud

elokda

Zidan

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…It is the third most common cancer in adult after lung cancer and breast cancer. Its incidence peak is at age 55-60 years (19) . In Egypt, CRC ranges the sixth, representing about 4% of total cancers in both genders (20) .…”

Section: Discussionmentioning

confidence: 99%

Assessment of immunhistochemical expression of CD44 and osteopontin in colorectal carcinoma

et al. 2023

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Background: Colorectal carcinoma considered the most worldwide concern and one of the major causes of morbidity and mortality rates. The cancer originates from a types of tumor cells, called cancer stem cells, they have important in the initiation of the tumor, invasion, metastasis, and therapeutic resistance. Among CSC markers, CD44 and OPN are two of the most investigated colorectal cancer markers and they are considered as the subpopulation with a greater tumorigenicity. This study aiming assessing the immunohistochemical expression of CD44 & OPN in colorectal adenomas & CRCs. And their relation between immunohistochemical expression of CD44 & OPN with tumor differentiation (grading), lympho-vascular invasion, perineural invasion, desmoplasia and TNM stage. Methods: the study is a retrospective descriptive study that included forty-two paraffin embedded blocks from the pathology laboratory, Suez Canal University Hospital. Paraffin blocks included, paraffin blocks reviewed for clinicopathological prognostic factors and stained by CD44 & OPN, monoclonal antibodies by immunohistochemical method. Results: The CD44 protein was expressed in 80% of CRC, the expression of CD44 and lympho-vascular invasion and tumor stage. Conclusions: CD 44 is highly expressed in large number of CRC (80 of tumors). It is also significantly more expressed in CRC than in adenomas, suggesting a role of CD 44 in CRC tumorigenesis and progression of adenomas into carcinomas. Our study also associated CD 44 overexpression with both late TNM stage and lymphovascular invasion.

show abstract

“…It is the third most common cancer in adults after lung cancer and breast cancer worldwide. Its incidence peaks at age 55-60 years (15) . In Egypt, CRC ranked the sixth, representing about 4% of total cancers in both sexes (16) .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Immunohistochemical Expression of CD44 in Colorectal Adenoma and Colorectal Carcinoma

Arafa

elokda

Zidan

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Colorectal cancer (CRC) is a foremost global health concern and remains one of the major causes of cancer-related morbidity and mortality. It is the third most common cancer in adults after lung cancer and breast cancer worldwide. The theory that cancer originates from a subpopulation of tumor cells, named cancer stem cells (CSC), they have an important role of CSC in the initiation and maintenance of the tumor, as well as invasion, metastasis, and therapeutic resistance. Among CSC markers, CD44 is the most investigated colorectal CSC markers. This study aims to assess the immunohistochemical expression of CD44 in colorectal adenomas & CRCs. And its relation between immunohistochemical expression of CD44 with tumor differentiation (grading), lympho-vascular invasion, perineural invasion, desmoplasia and TNM stage.Methods this is a retrospective descriptive study that included Sixty paraffin embedded blocks from the pathology laboratory, Suez Canal University Hospital. Paraffin blocks included (14 cases of colorectal carcinoma and 18 cases of colorectal adenoma). paraffin blocks reviewed for clinicopathological prognostic factors and stained by CD44, monoclonal antibodies by immunohistochemical method.Results The CD44 protein was overexpressed in 80% of CRC, while was positive (44.4%) in adenoma this difference was statistically.Conclusions CD 44 is highly expressed in large number of CRC (80 of tumors). It is also significantly more expressed in CRC than in adenomas, suggesting a role of CD 44 in CRC tumorigenesis and progression of adenomas into carcinomas. Our study also associated CD 44 overexpression with both late TNM stage and lympho-vascular invasion.

show abstract

Colorectal Carcinoma in Children and Adolescents in Low Middle Income Countries: Single Center Experience

Cited by 3 publications

References 12 publications

Assessment of Immunohistochemical Expression of CD44 and Osteopontin in Colorectal Carcinoma and colorectal adenoma

Assessment of Immunohistochemical Expression of CD44 and Osteopontin in Colorectal Carcinoma and colorectal adenoma

Assessment of immunhistochemical expression of CD44 and osteopontin in colorectal carcinoma

Assessment of Immunohistochemical Expression of CD44 in Colorectal Adenoma and Colorectal Carcinoma

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