Colorectal Carcinoma in Childhood: A Retrospective Multicenter Study

Abstract

Colorectal carcinoma in children is characterized by aggressive tumor behavior and delayed diagnosis, resulting in a worse prognosis than in adults. Heightened physician awareness of the possibility of this disease in children, with special attention to adolescents with predisposing factors and rectal bleeding, could help to improve outcome.

Different Clinical Manifestations Between Primary Gastrointestinal Malignancies and Benign Tumors in Children

“…This is most likely due to a failure to consider potential GI malignancy in pediatric patients, thus leading to delays in diagnosis that range from months to years (14)(15)(16)(17)(18)(19)(20). The median duration from onset to diagnosis of the present study is 1 month in the malignant group; however, interestingly, the median duration in the benign group (2 months) is longer than that of the malignant group, although without a statistically significant difference (P > 0.05).…”

Important considerations in treating children, adolescents and young adults with colorectal carcinoma

“…Some of the best evidence for a unique biology for AYA CRC compared with CRC in older adults includes more advanced tumor stage at diagnosis, a greater frequency of mucinous histology and signet-ring cells, high microsatellite instability (MSI) and mutations of mismatch repair (MMR) genes [32,34,35,[78][79][80]. Although several publications over the last two decades support the observation of poorer clinical outcomes for younger (<30 years old) patients compared with older adults [20][21][22]25,26,31,[33][34][35][36], these data are difficult to interpret. First, most of these reports are retrospective reviews of small numbers of patients that span a decade or more, making evaluations of treatment approaches difficult (Table 1).…”

Metastatic Liver Disease: Colorectal Carcinomas

“…Pediatric CRC can also develop in the setting of ulcerative colitis (Wilcox and Beattie 1956). Saner 1946;Scholefield 1946;Johnston 1947;Buchman and Calhoun 1958;Hoerner 1958;Salem and Postlethwait 1960;Donaldson et al 1971;Rao et al 1985;Koh and Johnson 1986;Lamego and Torloni 1989;Brown et al 1992; Ameh and Nmadu 2000; Kravarusic et al 2007;and Ferrari et al 2008.…”