Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles

Balaguer, Francesc; Moreira, Leticia; Lozano, Juan José; Link, Alexander; Ramirez, Georgina; Yan, Siyu; Cuatrecasas, Míriam; Arnold, Mildred; Meltzer, Stephen J.; Syngal, Sapna; Stoffel, Elena M.; Jover, Rodrigo; Llor, Xavier; Castells, Antoni; Boland, C. Richard; Gironella, Meritxell; Goel, Ajay

doi:10.1158/1078-0432.ccr-11-1424

Cited by 103 publications

(83 citation statements)

References 37 publications

(51 reference statements)

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“…In addition, more than one-third of all CRC-associated mortalities (29% in men and 43% in women) occurred in individuals aged ≥80 years (1). Lynch syndrome (LS), previously termed hereditary non-polyposis colorectal cancer (HNPCC), accounts for 3% of all CRCs and is caused by a germline mutation in one of the mismatch repair (MMR) genes mutL homolog 1 (MLH1), mutS homolog (MSH) 2, MSH6 and PMS1 homolog 2, mismatch repair system component (PMS2), and LS is the most common hereditary form of CRC (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome

Zhou

et al. 2016

Oncology Letters

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Abstract. The aim of the present study was to identify the differentially expressed microRNAs (DEMs) between Lynch syndrome (LS) and the normal colonic (N-C) control samples, predict the target genes (TGs) and analyze the potential functions of the DEMs and TGs. The miRNA expression dataset GSE30454, which included data of 13 LS and 20 N-C tissue samples, was downloaded from the Gene Expression Omnibus. The classical t-test in Linear Models for Microarray Data package was used for DEM identification. TG prediction was performed using 5 databases. The regulatory network of the DEMs and their TGs was constructed using Cytoscape. Functional and pathway enrichment analysis was performed. The transcription factors (TFs), tumor-associated genes (TAG) and tumor suppressor genes (TSGs) were then identified. Three key DEMs hsa-miR-137, hsa-miR-520e, and hsa-miR-590-3p were identified. Hsa-miR-520e and hsa-miR-137 had 4 common TGs, including SNF related kinase, metal-regulatory transcription factor 1 (MTF1), round spermatid basic protein 1 and YTH N6-methyladenosine RNA binding protein 3; hsa-miR-590-3p and hsa-miR-137 had 14 common TGs, including NCK adaptor protein 1 (NCK1), EPH receptor A7, and stress-associated endoplasmic reticulum protein 1; hsa-miR-590-3p and hsa-miR-520e had 12 common TGs, including Krüppel-like factor (KLF) 13, twinfilin actin binding protein 1, and nuclear factor I B. Through the functional and pathway enrichments analysis, MTF1 was involved in regulation of gene expression and metabolic processes, and sequence-specific DNA binding TF activity. KLF13 was involved in regulation of gene expression and regulation of cellular metabolic processes. NCK1 was enriched in the axon guidance pathway. In addition, the functional and pathway enrichment analysis showed certain TGs, such as hypoxia-inducible factor 1α, AKT serine/threonine kinase 2, and rapamycin-insensitive companion of mammalian target of rapamycin, participated in the mTOR signaling pathway. The 3 key DEMs hsa-miR-137, hsa-miR-520e, and hsa-miR-590-3p may have important roles in the process of LS.

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Section: Introductionmentioning

confidence: 99%

Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome

Zhou

et al. 2016

Oncology Letters

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“…MiRNAs have also been found to be differentially expressed in microsatellite stable (MSS) groups compared to microsatellite instable (MSI) in addition to subgroups (MSI-high and low) in CRC [161,207]. As stated earlier, MSI tumors have a favorable prognosis compared to MSS tumors and the identification of these patients might influence treatment decisions.…”

Section: E) Mirna As Prognostic Biomarkersmentioning

confidence: 84%

“…Examining the top five highly expressed miRNAs for association with clinicopathological parameters revealed that reduced expression of miR-192-5p was associated with increased pT stage and poorly differentiated tumors. Reduced expression of miR-192 has previously been associated with MSI status in CRC while overexpression of miR-192 exhibited reduced cell proliferation by targeting cell cycle progression [207,208,253,254]. 71 The expression patterns represented by hierarchical clustering reveal that the miRNAs were relatively uniformly expressed across all the patient samples thereby supporting the lack of associations between miRNA expression and clinicopathological parameters or outcome.…”

mentioning

confidence: 88%

Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients

et al. 2011

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“…Valeri et al [46] demonstrated the association of reduced expression of MSH2, MLH1 and MSH6 and induction of a mutator phenotype and MSI with over expression of miR-155 in LS. In another study, Balaguer et al [47] determined the up-regulation of miR-622 and miR-1238 in these patients. MSI status modulates the miRNA expression levels [48] .…”

Section: Lsmentioning

confidence: 96%

Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer

Tezcan

Tunca

et al. 2016

WJGO

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Colorectal cancer (CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC (EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, MutYH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach.

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Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles

Cited by 103 publications

References 37 publications

Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome

Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome

Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients

Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer

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