Colorectal cancer stem cells: overview and potential targeted therapy

Amalinei, Cornelia; Pricope, Diana-Lavinia; Grigoras¸, Adriana

doi:10.1016/b978-0-443-13212-4.00018-0

Cited by 2 publications

(2 citation statements)

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“…Colorectal cancer is a multifaceted disease with a complex interplay of genetic, environmental, and lifestyle factors contributing to its development. 1 Risk factors for colorectal cancer include age, family history, genetics, and certain lifestyle choices (Figure 2). The risk of developing colorectal cancer increases significantly with age, making regular screenings crucial for individuals over 50 years old.…”

Section: Overview Of Colorectal Cancer and Precision Medicinementioning

confidence: 99%

“…This cancer typically develops from the growth of abnormal cells in the lining of the colon or rectum and may take several years to progress from benign polyps to invasive cancer (Figure ). Colorectal cancer is a multifaceted disease with a complex interplay of genetic, environmental, and lifestyle factors contributing to its development …”

Section: Overview Of Colorectal Cancer and Precision Medicinementioning

confidence: 99%

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Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted therapy and immunotherapy selection. Biomarkers such as microsatellite instability (MSI) and DNA mismatch repair deficiency (dMMR) guide treatment decisions, opening avenues for immunotherapy. Emerging technologies such as liquid biopsies, artificial intelligence, and machine learning promise to revolutionize early detection, monitoring, and treatment selection in precision medicine. Despite these advancements, ethical and regulatory challenges, including equitable access and data privacy, emphasize the importance of responsible implementation. The dynamic nature of colorectal cancer, with its tumor heterogeneity and clonal evolution, underscores the necessity for adaptive and personalized treatment strategies. The future of precision medicine in colorectal cancer lies in its potential to enhance patient care, clinical outcomes, and our understanding of this intricate disease, marked by ongoing evolution in the field. The current reviews focus on providing in-depth knowledge on the various and diverse approaches utilized for precision medicine against colorectal cancer, at both molecular and biochemical levels.

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Section: Overview Of Colorectal Cancer and Precision Medicinementioning

confidence: 99%

Section: Overview Of Colorectal Cancer and Precision Medicinementioning

confidence: 99%