2020
DOI: 10.1101/2020.12.17.20242107
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Colorectal cancer screening within colonoscopy capacity constraints: can FIT-based programmes save more lives by trading-off more sensitive test cut-offs against longer screening intervals?

Abstract: IntroductionColorectal cancer (CRC) prevention programmes using faecal immunochemical testing (FIT) as the primary screen typically rely on colonoscopy for secondary and surveillance testing. Colonoscopy capacity is an important constraint, limiting the number of primary tests offered. Many European programmes lack sufficient colonoscopy capacity to provide optimal screening intensity regarding screening age ranges, intervals and FIT cut-offs. It is currently unclear how to optimise programmes within colonosco… Show more

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Cited by 3 publications
(3 citation statements)
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“…Concerningly, patients with colorectal cancers were the second-highest users of UEC, costing more than £3 million; efforts to redistribute stage and refine outcomes for this group should be priority policy decisions. In light of the significant morbidity and mortality in this disease [ 33 ], where there are existing screening programmes for early diagnosis, expanded access to the screening process with more effective disease detection testing thresholds might improve patient outcomes [ 34 ] and prompt reductions in UEC.…”
Section: Discussionmentioning
confidence: 99%
“…Concerningly, patients with colorectal cancers were the second-highest users of UEC, costing more than £3 million; efforts to redistribute stage and refine outcomes for this group should be priority policy decisions. In light of the significant morbidity and mortality in this disease [ 33 ], where there are existing screening programmes for early diagnosis, expanded access to the screening process with more effective disease detection testing thresholds might improve patient outcomes [ 34 ] and prompt reductions in UEC.…”
Section: Discussionmentioning
confidence: 99%
“…Concerningly, patients with colorectal cancers were the second-highest users of UEC, costing more than £3 million; efforts to redistribute stage and re ne outcomes for this group should be priority policy decisions. In light of the signi cant morbidity and mortality in this disease 33 , where there are existing screening programmes for early diagnosis, expanded access to the screening process, with more effective disease detection testing thresholds might improve patient outcomes 34 and prompt reductions in UEC.…”
Section: Discussionmentioning
confidence: 99%
“…Un estudio irlandés utilizó una metodología de micro-simulación 118 , para evaluar qué estrategia puede optimizar las acciones de rastreo de CCR, dado que en ese país también tienen restricciones para el acceso a la VCC. Consideraron variar el punto de corte de la detección de hemoglobina de la SOMF, variar el intervalo entre la realización de la prueba fecal y realizar el rastreo a diferentes edades.…”
Section: Evaluación De Indicadores De Implementación Del Programa Pro...unclassified