Colorectal cancer screening prevalence and predictors among Asian American subgroups using Medical Expenditure Panel Survey National Data

Sy, Angela; Lim, Eunjung; Ka’opua, Lana Sue; Kataoka‐Yahiro, Merle; Kinoshita, Yumiko; Stewart, Susan L.

doi:10.1002/cncr.31098

Cited by 13 publications

(21 citation statements)

References 27 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different mechanisms, which eventually contribute to traditional cytotoxic therapeutic resistance, are typically accomplished by generating drug efflux pumps to diminish the delivery of the drug to the target site inside the cancer cell, or by changing the enzymes involved in drug metabolism. Alternately, multi-drug resistance can be generated by genetic and epigenetic modification leading to altered drug sensitivity and mediating at one least mechanism by ATP binding cassette (ABC) protein transporters, responsible for the decreased drug uptake into the cancer cells and exerting their mode of action through diminishing the intracellular concentration of the chemotherapeutic drug, which subsequently leads to the generation of drug resistance (Van der Jeught, 2018). The role of ABC transporters has been postulated in drug resistance and might be instigated via the drug efflux mechanism and can interfere with 5-FU activity to rapidly impede both DNA and RNA synthesis processes.…”

Section: Figurementioning

confidence: 99%

“…Matrix metalloproteinases (MMPs) is an important enzyme that degrades the extracellular matrix, while collagen type IV and gelatin were the main substrates for these enzymes. In particular, matrix metalloproteinases-9 (MMP-9) or gelatinase B is constitutively expressed in various cell types, including keratinocytes, macrophages, polymorphonuclear leukocytes, and some malignant tumor cells (Mackay et al, 1992;Van den Steen, 2002). MMP-9 can degrade many extracellular matrix (ECM) proteins through proteolytic cleavage and is closely related to ECM remodeling which supports tumor invasion and metastasis.…”

Section: Figurementioning

confidence: 99%

“…Colorectal cancer (CRC) is a cancer type that is aberrantly generated in the Thai population and is closely linked to the rapidly increasing incidence rates of morbidity in malignant neoplasia (Sy et al, 2018). As described in the National Comprehensive Cancer Network Guidelines (2018), patients are guided towards regimens which are commonly used as chemotherapy regimens for CRC including 5-FU/LV, Capecitabine, CAPEOX, FOLFIRI, and FOLFOX (National Comprehensive Cancer Network Guidelines for colorectal cancer, 2018).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fucoxanthin enhances 5-FU chemotherapeutic efficacy in colorectal cancer cells by affecting MMP-9 invasive proteins

Manmuan¹,

Manmuan²

2019

J app pharm sci

View full text Add to dashboard Cite

Drug resistance is a major inconvenience which lowers the traditional chemotherapeutic efficacy and is a highly undesirable therapeutic problem which poses particular challenges in the case of colorectal cancer. Fucoxanthin is a natural orange-carotenoid, predominantly found in edible brown algae and justifiably considered as a nutritional ingredient with the capacity to powerfully enhance concurrent drug chemotherapy. It has been well-documented that fucoxanthin has good potential for anti-cancer activity while offering a remarkable range of biological activities. Accordingly, it has gained prominence in the research field as interest grows in the molecular mechanism which is associated with cancer therapy. This study was undertaken to assess the anti-cancer activity and to explore the molecular mechanism of fucoxanthin on the inhibition of cell proliferation, cell adhesion, and cell invasion, in addition to determining the synergistic effect of drug-drug combinative treatment in colorectal cancer cells. SW-620 cells were cultivated with fucoxanthin for 24, 48, 72, and 96 hours with co-treatment by 5-FU to evaluate the synergistic potential. The cell viability of cancerous cells was determined by MTT colorimetric assay. The inhibitory effects of cell invasion and adhesion were measured in the presence of fucoxanthin with 5-FU in various concentrations to determine MMP-9 gene and protein expression after treatment of the cells by RT-PCR and ELISA assay. The results illustrated that fucoxanthin profoundly inhibited cell proliferation of SW-620 cells, accompanied by arrested growth and diminished invasive ability, which was mediated at least in part by the down-regulation of MMP-9, mRNA, and protein expression. In particular, fucoxanthin strongly attenuated the anti-proliferative effect of established 5-FU by modulating the habitual hallmark of cancerous cells. These results illustrate the capacity of fucoxanthin to eradicate cancer cells and indicate the possibility that fucoxanthin could serve as a promising natural marine product derived from seaweed. The critical data in our studies will serve as the preliminary results for further studies of marine drugs in both experimental models and well-controlled clinical trials.

show abstract

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fucoxanthin enhances 5-FU chemotherapeutic efficacy in colorectal cancer cells by affecting MMP-9 invasive proteins

Manmuan¹,

Manmuan²

2019

J app pharm sci

View full text Add to dashboard Cite

show abstract

“…Despite guidance and recommendations, overall screening rates remain below the 80% target rate endorsed by The National Colorectal Cancer Round Table 6 . Roughly one‐third of eligible adults in the US are not up‐to‐date with CRC screening or have not been screened for CRC, and adherence to screening recommendations varies between sub‐groups in the population 7–10 …”

Section: Introductionmentioning

confidence: 99%

Colorectal cancer screening preferences among physicians and individuals at average risk: A discrete choice experiment

et al. 2022

View full text Add to dashboard Cite

Background: Guidelines include several options for average-risk colorectal cancer (CRC) screening that vary in aspects such as invasiveness, recommended frequency, and precision. Thus, patient and provider preferences can help identify an appropriate screening strategy. This study elicited CRC screening preferences of physicians and individuals at average risk for CRC (IAR).Methods: IAR aged 45-75 years and licensed physicians (primary care or gastroenterology) completed an online discrete choice experiment (DCE). Participants were recruited from representative access panels in the US. Within the DCE, participants traded off preferences between screening type, screening frequency, true-positive, true-negative, and adenoma true positive (physicians only). A mixed logit model was used to obtain predicted choice probabilities for colonoscopy, multi-target stool DNA (mt-sDNA), fecal immunochemical test (FIT), and methylated septin 9 (mSEPT9) blood test.Results: Preferences of IAR and physicians were affected by screening precision and screening type. IAR also valued more regular screening. Physicians preferred colonoscopy (96.8%) over mt-sDNA (2.8%; p < 0.001), FIT (0.3%; p < 0.001) and mSEPT9 blood test (0.1%; p < 0.01). IAR preferred mt-sDNA (38.8%) over colonoscopy (32.5%; p < 0.001), FIT (19.2%; p < 0.001), and mSEPT9 blood test (9.4%; p < 0.001). IAR naïve to screening preferred non-invasive screening (p < 0.001), while the opposite was found for those who previously underwent colonoscopy or sigmoidoscopy.Conclusions: While physicians overwhelmingly preferred colonoscopy, preferences of IAR were heterogenous, with mt-sDNA being most frequently preferred on average. Offering choices in addition to colonoscopy could improve CRC screening uptake among IAR.

show abstract

“…The prevalence of CRC is high-frequency in America, North-Western Europe, Australia, Japan, China, Singapore, and Canada, and the lower one is reported in African and Asian countries, including Iran (third common malignancy in Iran) [2][3][4]. The National Colorectal Cancer Roundtable in 2015 suggested, there was an upward tendency in the CRC prevalence, and it could reach up to 80% [5]. Some kinds of therapeutic trends, such as surgery, radiation and chemotherapy have considerable outcome for these patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of herpes simplex, varicella zoster and Cytomegalovirus in tumorous and adjacent tissues of patients, suffering from colorectal cancer in Iran

et al. 2019

View full text Add to dashboard Cite

Background: Colorectal cancer (CRC) can be considered as a result of multiple risks factors, and the significant role of infectious ones, especially viral diseases could not be underestimated. Despite endorsed attempts to identify the accelerating effects of different herpes viridea, such as HSV-1, HSV2, VZV and CMV on the deterioration of different kinds of malignancy, the relationship between these viruses and CRC have not successfully been understood. Taking advantages of these facts, we assessed the role of these viruses on CRC progression. Methods: In this case-control study, 88 cancerous specimens and 70 their adjacent paraffin-embedded tissues from Modares Hospital between 2011 and 2019 were collected. We extracted the DNA of each tissue and investigated the presence of HSV-1, HSV2, VZV and CMV. Results: Our data indicated the presence of HSV-1 DNA in the three control samples; however, we could not find an obvious relationship between HSV2, VZV, CMV infection and this type of cancer. The presence of HSV-1 DNA in control tissues introduced HSV-1 as a probable factor for the killing of colorectal cancer cells. Conclusions: we supposed that HSV-1 can function as an inhibitor of colon cancer progresion, but it is required to studied more in order to find the role of this virus on CRC.

show abstract

Colorectal cancer screening prevalence and predictors among Asian American subgroups using Medical Expenditure Panel Survey National Data

Cited by 13 publications

References 27 publications

Fucoxanthin enhances 5-FU chemotherapeutic efficacy in colorectal cancer cells by affecting MMP-9 invasive proteins

Fucoxanthin enhances 5-FU chemotherapeutic efficacy in colorectal cancer cells by affecting MMP-9 invasive proteins

Colorectal cancer screening preferences among physicians and individuals at average risk: A discrete choice experiment

Prevalence of herpes simplex, varicella zoster and Cytomegalovirus in tumorous and adjacent tissues of patients, suffering from colorectal cancer in Iran

Contact Info

Product

Resources

About