Colorectal Cancer Screening

Garborg, Kjetil

doi:10.1016/j.suc.2015.05.007

Cited by 25 publications

(22 citation statements)

References 61 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many investigations have indicated that selected chemokines may be involved in tumor development as well as in supporting the formation of the metastatic spread [20]. A prime example is chemokine CXCL-8, which has demonstrated to be involved in tumor angiogenesis and linked with promoting distant metastases in many malignancies, including CRC [21].…”

Section: Discussionmentioning

confidence: 99%

CXCL-8 in Preoperative Colorectal Cancer Patients: Significance for Diagnosis and Cancer Progression

Pączek

Łukaszewicz-Zając

Gryko

et al. 2020

IJMS

View full text Add to dashboard Cite

Introduction. Since colorectal cancer (CRC) is the second most commonly diagnosed malignancy in Europe and third worldwide, novel biomarkers for diagnosing the disease are critically needed. Objectives. According to our knowledge, the present study is the first to evaluate the clinical usefulness of serum CXCL-8 (C-X-C motif chemokine 8) in the diagnosis and progression of CRC compared to classical tumor marker CEA (carcinoembryonic antigen) and marker of inflammation CRP (C-reactive protein). Patients and Methods. The study included 59 CRC patients and 46 healthy volunteers. Serum levels of selected proteins were measured using ELISA (enzyme-linked immunosorbent assay), CMIA (chemiluminescent microparticle immunoassay), and immunoturbidimetric methods. Results. Serum concentrations of CXCL-8, similarly to those of the classical tumor marker CEA and inflammatory state marker CRP, were significantly higher in CRC patients than in healthy controls. There were statistically significant differences in CXCL-8 concentrations between tumor stages, as established by the Kruskal–Wallis test and confirmed by the post hoc Dwass–Steele–Critchlow–Fligner test. CXCL-8 levels were also significantly elevated in CRC patients with distant metastases compared to patients in the subgroup without metastases. Diagnostic sensitivity, predictive values for negative results (NPV), and AUC (area under the Receiver Operating Characteristic Curve—ROC curve) of CXCL-8 were higher than those of CEA, while diagnostic specificity and predictive values for positive results (PPV) of CXCL-8 were higher than those of CRP. Conclusions. Our findings indicate greater utility of CXCL-8 in comparison to the classical tumor marker CEA in the diagnosis of CRC. Moreover, serum CXCL-8 might be a potential biomarker of colorectal cancer progression.

show abstract

Section: Discussionmentioning

confidence: 99%

CXCL-8 in Preoperative Colorectal Cancer Patients: Significance for Diagnosis and Cancer Progression

Pączek

Łukaszewicz-Zając

Gryko

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Despite recent advances in treatment, overall survival remains poor in advanced colorectal cancer patients [1–3]. Metastasis is a major cause of death in patients with a variety of cancers.…”

Section: Introductionmentioning

confidence: 99%

Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer

Park

Lee

et al. 2016

Oncotarget

View full text Add to dashboard Cite

Filamin A interacting protein 1-like (FILIP1L) expression, which is decreased in various cancers, may inhibit carcinogenesis. In this study, we evaluated the effects of FILIP1L on oncogenic behavior and prognosis in colorectal cancer. siRNA-mediated FILIP1L knockdown enhanced tumor cell migration and invasion and inhibited apoptosis and cell cycle arrest in COLO205 cells. pcDNA-myc vector-mediated FILIP1L overexpression suppressed tumor cell migration and invasion and induced apoptosis and cell cycle arrest in HCT116 cells. FILIP1L knockdown enhanced angiogenesis by increasing VEGF-A and HIF-1α levels and decreasing angiostatin level. FILIP1L overexpression suppressed angiogenesis by decreasing VEGF-A and -D l level and increasing angiostatin and endostatin levels. Phosphorylated β-catenin levels decreased and phosphorylated Akt and GSK-3β levels increased following FILIP1L knockdown. FILIP1L overexpression had the opposite effects. FILIP1L expression was associated with reductions in tumor size, cell differentiation, lymphovascular invasion, stage, invasion depth and lymph node metastasis, and with longer overall survival. Mean Ki-67 labeling indexes and microvessel density values were lower in FILIP1L-positive tumors than in FILIP1L-negative tumors. These results indicate that FILIP1L suppresses tumor progression by inhibiting cell proliferation and angiogenesis in colorectal cancer.

show abstract

“…Among the recommended CRC screening modalities, colonoscopy is widely preferred and considered the gold standard given the advantage of cancer prevention via removal of adenomatous polyps 4 5. This has been well established by the findings in the National Polyp Study 28.…”

Section: Discussionmentioning

confidence: 99%

“…It has been estimated that if the national guidelines for CRC screening were strictly followed, as many as 60% of deaths from CRC could be prevented 3. Colonoscopy is currently the most commonly used CRC screening modality within the USA, likely owing to its ability to provide complete visualisation of the colon and rectum, while simultaneously allowing for tissue sampling and polyp removal 4. Although the overall percentage of USA adults aged over 50 years who received CRC screening by either faecal occult blood test, sigmoidoscopy or colonoscopy nearly doubled from 34.8% in 1987 to 66.1% in 2010, approximately 40% of Americans are still not receiving CRC screening according to the national guidelines 3 5.…”

Section: Introductionmentioning

confidence: 99%

Training mid-career internists to perform high-quality colonoscopy: a pilot training programme to meet increasing demands for colonoscopy

Shah-Ghassemzadeh

Jackson²,

Juma

et al. 2017

Postgraduate Medical Journal

View full text Add to dashboard Cite

Background Colorectal cancer (CRC) is the second leading cause of cancer deaths in the USA. Despite a recent rise in CRC screening there remains an increasing demand for colonoscopy, yet a limited supply of gastroenterologists who can meet this need. Objective To determine if a mid-career general internist (GIN) could be trained to perform high-quality colonoscopes via an intensive training programme. Design A GIN trained 2-3 days/week, 4-5 hours/day, for 7 months with an experienced gastroenterologist. Their independent performance was then compared with that of a gastroenterology attending (GA), with and without a gastroenterology fellow (GF). Main measures The primary outcome was to compare caecal intubation rates, adenoma detection rates (ADRs), interval CRC rates and complications between the three groups. Key results 989 patients were initially included in the study, and 818 were included in the final analysis. Caecal intubation rates were 95%, 94% and 93% for the GIN, GA+GF and GA, respectively ( p=0.31). The overall polyp detection rates were 68%, 39% and 44% among the GIN, GA+GF and GA, respectively ( p<0.0001). The ADRs were 56%, 33% and 34% for the GIN, GA+GF and GA, respectively ( p<0.0001). Three complications occurred, all within the GA group. No interval cancers were diagnosed within a 5-year surveillance period, across all three groups. Conclusions The GIN attained high success rates in all quality measures. Training mid-career GINs to perform high-quality screening colonoscopes, through a standardised curriculum, may be a reasonable approach to address the growing demand for colonoscopists. BACKGROUND

show abstract

Colorectal Cancer Screening

Cited by 25 publications

References 61 publications

CXCL-8 in Preoperative Colorectal Cancer Patients: Significance for Diagnosis and Cancer Progression

CXCL-8 in Preoperative Colorectal Cancer Patients: Significance for Diagnosis and Cancer Progression

Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer

Training mid-career internists to perform high-quality colonoscopy: a pilot training programme to meet increasing demands for colonoscopy

Contact Info

Product

Resources

About