Colorectal Cancer Mortality in Brazil

Souza, Dyego Leandro Bezerra de; Jerez-Roig, Javier; Cabral, Francisco J.; Lima, J. R.; Rutalira, Michael K.; Costa, Juan Adrizio G.

doi:10.1097/dcr.0000000000000186

Cited by 34 publications

(19 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are also disparities in the quality of the data between urban and rural areas of Brazilian states as well as in cities of smaller and larger populations [31]. While the quality of death notices and the percentage of under-reporting in Brazil seems to be improving in most states, the results reported for some regions still must be considered with caution, as the proportion of improperly defined causes of death can reach 10% in the Northern and Northeastern states of Brazil, leading to an underestimation of the mortality rates [32, 33]. Finally, the findings must be treated carefully in order to avoid the ecological fallacy of using aggregate results to make any inferences at the individual level.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated a steady increase in mortality rates for this type of cancer in Brazilian regions, especially in the South and Southeast, which presented rates similar to those of highly industrialised countries [5, 6]. Socioeconomic standards of individuals or population groups are evaluated through indicators, as they allow for international comparisons.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Socioeconomic differentials and mortality from colorectal cancer in large cities in Brazil

Parreira

Meira

Guimarães

2016

ecancer

View full text Add to dashboard Cite

The objective of this study was to compare the mortality pattern of colorectal cancer according to the social development profile of the large Brazilian cities. This was an ecological study that used as units of analysis Brazilian municipalities that were considered to be large (i.e. over 100,000 inhabitants). The social indicators adopted were obtained from the Atlas of Human Development in Brazil. Mortality data came from the Mortality Information System (MIS), represented by codes C18, C19, and C20. For data analysis, municipalities were characterised according to the indicator profile used by multivariate classification cluster analysis. It was observed that the Southeast, South, and Midwest regions concentrated over 90% of cities in the group of more developed municipalities, while the North and Northeast regions were represented by 60% of cities in the group of less developed municipalities. The mortality pattern of colorectal cancer in both groups was different, with a higher average mortality rate from colorectal cancer for populations living in cities from the more developed group (p = 0.02). The mortality rate from this cancer was shown to be directly proportional to the Municipal Human Developlemnt Index (MHDI) and inversely proportional to the inequality indicator (p < 0.001); therefore the highest means were observed among the municipalities with better socioeconomic conditions. It is important to consider social disparities to ensure equity in healthcare policy management.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Socioeconomic differentials and mortality from colorectal cancer in large cities in Brazil

Parreira

Meira

Guimarães

2016

ecancer

View full text Add to dashboard Cite

show abstract

“…CRC is the third most common neoplasia in the world and the fifth cause of cancer-related death in Southern Brazil [1]. There has been a significant increase in the global CRC incidence over the last 20 years and a still greater increase in CRC incidence is expected by 2025, due to population aging [2].…”

Section: Introductionmentioning

confidence: 99%

Clinical impact of the immunochemical fecal occult blood test for colorectal cancer screening in Brazil

Teixeira

Bonotto²,

Lima³

et al. 2017

aog

View full text Add to dashboard Cite

BackgroundColorectal cancer (CRC) screening programs based on the fecal occult blood test (FOBT) reduce CRC mortality. We carried out an observational prospective study to determine the accuracy of immunochemical FOBTs for the detection of CRC in individuals at average risk for the disease.MethodsThis population-based study was performed between April 2015 and January 2016 in two gastroenterology referral centers in Southern Brazil. It included 1039 average-risk volunteers aged 50-75 years who were symptom-free for colonic disease. Participants underwent OC-Light immunochemical fecal occult blood test (i-FOBT, EIKEN chemical Co., Tokyo, Japan) as well as screening colonoscopy.ResultsNine hundred forty-eight (91.2%) of the 1039 participants completed and returned the i-FOBT (95% confidence interval [CI] 89.4-92.9). Among the 73 participants with a positive i-FOBT who underwent colonoscopy, advanced CRC was detected in 9 (12.3%). Two (2.7%) early CRCs, 7 (9.5%) high-grade dysplasia adenomas and 25 (34.2%) low-grade dysplasia adenomas were also diagnosed. Among the 243 negative i-FOBT cases who underwent colonoscopy, one (0.4%) advanced CRC and 91 (37.6%) low-grade dysplasia adenomas were detected. The detection rate of CRC considering the whole screened population (n=1039) was 1.05% (11/1039).ConclusionsThe i-FOBT test in the CRC screening programs in Brazil showed a high compliance and high detection rates for cancers and high-risk adenomas. The i-FOBT test is feasible for CRC screening in an average-risk population.

show abstract

“…Colorectal cancer is one of the most prevalent worldwide 6 . In the United States, the disease is the third most diagnosed neoplasia 7 , whereas in Brazil it is among the six most prevalent types of cancer 8 . The most common symptoms are changes in bowel habits, weight loss, abdominal pain, hematochezia, and anemia 9 .…”

Section: Introductionmentioning

confidence: 99%

“…Regarding men and women in Brazil, the prevalence varies between 35 and 72%, with high-risk HPVs being responsible for 25-56% of cases. When the precancerous lesions and lesions linked to cancer are assessed, it is observed that HPV 16 and 18 are responsible for approximately 55% of the cases with high-risk lesions and around 70% of cases of cervical cancer, both in South America and in Brazil 8 . Another risk factor is the genetic predisposition, such as familial adenomatous polyposis or first degree relatives with colorectal cancer 12 .…”

Section: Introductionmentioning

confidence: 99%

Prevalência de câncer colorretal associado ao papilomavírus humano: uma revisão sistemática com metanálise

Pelizzer

Dias

Poeta

et al. 2016

Rev. bras. epidemiol.

View full text Add to dashboard Cite

Introduction:Colorectal cancer is one of the most prevalent types of tumors worldwide. Deaths caused by these malignant tumors remain high and have stayed practically at the same level for the last few decades. Among the established risk factors for the development of cancer are infections due to pathogens or viruses. Among the viruses, the human papillomavirus (HPV) is the most prevalent, with over 180 strains, 40 of which are directly related to anogenital infections. Objective: Systematically assess the main studies which link HPV to colorectal cancer with meta-analysis. Methods: The search strategy adopted was the logic based on specific descriptors (English language), in combination with the Boolean operators (AND/OR). The search was conducted in the following databases: PubMed, ScienceDirect, and Scientific Electronic Library Online (SciELO), between April and May 2015. Results: 1,549 samples were assessed, with 956 (61.7%) being males. Six hundred thirty out of 1,358 cases of colorectal cancer due to HPV were diagnosed (51.9%). From these, 408 of 767 (51.9%) were male and 404 of 598 (67.5%) were linked to HPV 16 and 18, with tumor prevalence in the area of the cervix (253 of 411; 61.3%). From the total of 598 samples for the prevalence estimate of HPV 16 and 18, the number of cases with similar numbers was 204 (31.7%) and 200 (35.8%), respectively. Relatively significant numbers were found in the area of the cervix, 253 (61.3%), and the area of the rectum, 158 (38.7%). Conclusion: After conducting the present study, the link between HPV and colorectal cancer was made evident, without a distinction between the sexes, with similar values between HPV 16 and HPV 18.

show abstract

Colorectal Cancer Mortality in Brazil

Cited by 34 publications

References 27 publications

Socioeconomic differentials and mortality from colorectal cancer in large cities in Brazil

Socioeconomic differentials and mortality from colorectal cancer in large cities in Brazil

Clinical impact of the immunochemical fecal occult blood test for colorectal cancer screening in Brazil

Prevalência de câncer colorretal associado ao papilomavírus humano: uma revisão sistemática com metanálise

Contact Info

Product

Resources

About