Colorectal cancer: Metabolic interactions reshape the tumor microenvironment

Chen, Jiawei; Zhu, Haodong; Ye, Yin; Jia, Siyuan

doi:10.1016/j.bbcan.2022.188797

Cited by 29 publications

(17 citation statements)

References 104 publications

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“…The intricate tumor microenvironment (TME) of CRC signi cantly impacts patient prognoses, which encompasses not only the tumor cells but also includes tumor-associated broblasts, endothelial cells, and various in ltrating immune cells (Chen et al, 2022). Recognizing the critical role of immune cell in ltration in solid tumors, our study delved into the in uence of prognostic signature DAGs on the in ltration levels of diverse immune cells.…”

Section: Discussionmentioning

confidence: 99%

Analysis of autophagy-related gene signature associated with clinical prognosis and immune microenvironment in colorectal cancer

Miao,

Song,

Liang

et al. 2024

Preprint

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Purpose: Autophagy has a critical involvement in the initiation and progression of various cancers, including colorectal cancer (CRC). The feasibility of using autophagy-related genes as prognostic tools for CRC patients is yet to be determined. Methods: We gathered RNA sequencing data and clinical details for colorectal cancer (CRC) from TCGA as our training set and used the GSE39582 dataset from the GEO database for validation. Autophagy-related genes (ARGs) were obtained from the Human Autophagy Database. Using the R limma package, we identified differentially expressed ARGs (DAGs) in TCGA's CRC samples. Prognostic DAGs signatures were established via Cox and LASSO Cox regression analyses. CRC patients were divided into high-risk and low-risk groups based on median risk scores, with their prognosis assessed through Kaplan-Meier, ROC, and calibration curve analyses. The CIBERSORT algorithms were employed to examine the association between immune status and the signature. Immunohistochemistry assays were conducted to evaluate the prognostic significance of these DAGs in CRC samples. Results: Our study developed a signature consisting of 11 key prognostic DAGs (CANX, NRG1, WIPI1, EIF2AK3, WDR45, PELP1, ULK1, WIPI2, DAPK1, ULK3, MAP1LC3C), revealing that high-risk patients had markedly reduced overall survival compared to low-risk ones. This signature, independently predictive after adjusting for clinical factors, was validated using the GSE39582 dataset and showed a strong correlation with immune status in TCGA CRC samples. Conclusion: The autophagy-related signature independently predicts CRC prognosis and guides immunotherapy strategies.

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Section: Discussionmentioning

confidence: 99%

Analysis of autophagy-related gene signature associated with clinical prognosis and immune microenvironment in colorectal cancer

Miao,

Song,

Liang

et al. 2024

Preprint

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“…Signal messengers, including cytokines, metabolites, and exosomes, derived from cancer cells can be utilized by the surrounding cells within the TME to induce metabolic alteration and cancer-associated transformation. In turn, the cargos secreted from cancer-associate cells further provide the nutrition and energy supply for cancer cells, supporting their metabolic reprogramming to promote proliferation, migration, metastasis, and radiochemoresistance [ 17 ]. The TME has a dynamic composition including various cell types, such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages, regulatory T cells, and myeloid-derived suppressor cells, as well as extracellular factors surrounding cancer cells which has functional and structural roles under physiological and pathological conditions [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Prognostic and therapeutic value and clinical implications of fibroblast activation protein-α as a novel biomarker in colorectal cancer

et al. 2023

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The identification of contributing factors leading to the development of Colorectal Cancer (CRC), as the third fatal malignancy, is crucial. Today, the tumor microenvironment has been shown to play a key role in CRC progression. Fibroblast-Activation Protein-α (FAP) is a type II transmembrane cell surface proteinase expressed on the surface of cancer-associated fibroblasts in tumor stroma. As an enzyme, FAP has di- and endoprolylpeptidase, endoprotease, and gelatinase/collagenase activities in the Tumor Microenvironment (TME). According to recent reports, FAP overexpression in CRC contributes to adverse clinical outcomes such as increased lymph node metastasis, tumor recurrence, and angiogenesis, as well as decreased overall survival. In this review, studies about the expression level of FAP and its associations with CRC patients' prognosis are reviewed. High expression levels of FAP and its association with clinicopathological factors have made as a potential target. In many studies, FAP has been evaluated as a therapeutic target and diagnostic factor into which the current review tries to provide a comprehensive insight.

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“…Colorectal cancer (CRC), a malignant tumor of the gastrointestinal tract, which derives from the epithelial cells of the colon or rectum, with the highest incidence and tumor-related mortality ( 1 ). The occurrence and progression of CRC are extremely connected with the patient’s age, gender, lifestyle, dietary habits, and genetic factors ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Crosstalk between colorectal cancer cells and cancer-associated fibroblasts in the tumor microenvironment mediated by exosomal noncoding RNAs

Sun

Zhang

et al. 2023

Front. Immunol.

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Colorectal cancer (CRC) is a common malignant tumor of the digestive system, and its morbidity rates are increasing worldwide. Cancer-associated fibroblasts (CAFs), as part of the tumor microenvironment (TME), are not only closely linked to normal fibroblasts, but also can secrete a variety of substances (including exosomes) to participate in the regulation of the TME. Exosomes can play a key role in intercellular communication by delivering intracellular signaling substances (e.g., proteins, nucleic acids, non-coding RNAs), and an increasing number of studies have shown that non-coding RNAs of exosomal origin from CAFs are not only closely associated with the formation of the CRC microenvironment, but also increase the ability of CRC to grow in metastasis, mediate tumor immunosuppression, and are involved in the mechanism of drug resistance in CRC patients receiving. It is also involved in the mechanism of drug resistance after radiotherapy in CRC patients. In this paper, we review the current status and progress of research on CAFs-derived exosomal non-coding RNAs in CRC.

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Colorectal cancer: Metabolic interactions reshape the tumor microenvironment

Cited by 29 publications

References 104 publications

Analysis of autophagy-related gene signature associated with clinical prognosis and immune microenvironment in colorectal cancer

Analysis of autophagy-related gene signature associated with clinical prognosis and immune microenvironment in colorectal cancer

The Prognostic and therapeutic value and clinical implications of fibroblast activation protein-α as a novel biomarker in colorectal cancer

Crosstalk between colorectal cancer cells and cancer-associated fibroblasts in the tumor microenvironment mediated by exosomal noncoding RNAs

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