Colorectal cancer lymph node staining by activated carbon nanoparticles suspension<i>in vivo</i>or methylene blue<i>in vitro</i>

Cai, Hongke; He, Haifei; Tian, Wei; Zhou, Meiqi; Hu, Yue; Deng, Yongchuan

doi:10.3748/wjg.v18.i42.6148

Cited by 54 publications

(61 citation statements)

References 37 publications

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“…It has been reported that ACNs were used as a tracer to increase the detected number of lymph nodes in the systematic nodal dissection tissue during video-assisted thoracic surgery for non-small-cell lung cancer [21]. Cai et al found that the mean number of detected lymph nodes per patient in CRC was significantly higher in the ACN group than in the control group [22]. In the present work, the quantity of harvested lymph nodes was significantly higher in the ACN group than in the control group, and the majority of retrieved lymph nodes were coloured black, demonstrating the outstanding tracing feature of ACN, helping the identification of lymph nodes from surrounding fat tissue.…”

Section: Discussionmentioning

confidence: 99%

Effect of activated carbon nanoparticles on lymph node harvest in patients with colorectal cancer

et al. 2019

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Aim The aim was to examine the effect of activated carbon nanoparticles (ACNs) on lymph node retrieval in colorectal cancer (CRC) patients. Methods This prospective randomized study of 80 subjects was performed between March 2016 and December 2016. Eighty patients with CRC were randomly divided into two groups, the ACN group and a control group. The patients in the ACN group were subjected to 1 ml of ACN injection in the subserosa around the tumour before colectomy and D3 lymphadenectomy. The patients in the control group received the same procedure without the injection of ACNs. After surgery, lymph nodes were isolated, and the greatest dimensions were measured by the same pathologist. Results The average number of lymph nodes harvested from each patient was markedly more in the ACN group (31.3 ± 8.1) than in the control group (21.9 ± 5.3; P < 0.001), and the average number of lymph nodes less than 5 mm in greatest dimension was significantly more in the ACN group (11.9 ± 4.9) than in the control group (4.1 ± 2.4; P < 0.001). The ACN group (15/40) had a higher rate of Stage III patients compared to the control group (6/39; P = 0.026). Besides, the greatest dimension of 32.8% metastatic lymph nodes was less than 5 mm. Conclusion There is significant upstaging following the use of ACNs, which could find more involved nodes. Therefore, ACNs can be used as a tracer to harvest more lymph nodes in CRC patients, with improvement in the accuracy of pathological staging.

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Section: Discussionmentioning

confidence: 99%

Effect of activated carbon nanoparticles on lymph node harvest in patients with colorectal cancer

et al. 2019

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“…However, some drawbacks, such as insufficient stability, short duration, and parathyroid staining, limit their usage in the surgery of PTC . Recently, activated carbon has been widely applied as a lymph node tracer in breast and gastric cancers . With the development of nanotechnology, carbon nanoparticles have been used as a novel lymph node tracer in malignant tumors since its approval in 2007 .…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Recently, activated carbon has been widely applied as a lymph node tracer in breast and gastric cancers. [20][21][22] With the development of nanotechnology, carbon nanoparticles have been used as a novel lymph node tracer in malignant tumors since its approval in 2007. 4,22 Carbon nanoparticle injections have also been used for helping identify lymph nodes in lymph node dissection or as tracers for sentinel lymph node biopsy in patients with PTC.…”

Section: Discussionmentioning

confidence: 99%

“…[20][21][22] With the development of nanotechnology, carbon nanoparticles have been used as a novel lymph node tracer in malignant tumors since its approval in 2007. 4,22 Carbon nanoparticle injections have also been used for helping identify lymph nodes in lymph node dissection or as tracers for sentinel lymph node biopsy in patients with PTC. 4 We further evaluate the feasibility of intraoperative injection of carbon nanoparticles as a lymphatic tracer and as guidance for lymph nodes dissection in clinically node-negative patients with PTC in this study.…”

Section: Discussionmentioning

confidence: 99%

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Carbon nanoparticle–guided central lymph node dissection in clinically node‐negative patients with papillary thyroid carcinoma

et al. 2015

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“…[10,11] This product is a stable suspension of carbon pellets of 150 nm in diameter. The diameter of carbon pellets is greater than the capillary endothelial cell gap (approximately 20–50 nm) and smaller than the lymphatic capillary endothelial cell gap (approximately 120–500 nm).…”

Section: Methodsmentioning

confidence: 99%

Potential role of carbon nanoparticles in protection of parathyroid glands in patients with papillary thyroid cancer

Zhu

et al. 2016

Medicine

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As a novel type of lymphatic tracer, carbon nanoparticles (CNs) were reported not to stain parathyroid glands (PGs) into black, so it may have a clinical potential in protection of PGs during thyroidectomy. The purpose of this study was to investigate the clinical application and significance of CN in protection of PGs from surrounding tissues.A total of 82 consecutive patients were enrolled into this study and were divided into CN group and control group. Parathyroid function (hypoparathyroidism and hypocalcemia) was evaluated.The identification rates of PGs (≤2) and PGs (≥3) were 24.4% and 75.6% in the CN group and 46.3% and 53.7% in the control group, respectively. The difference in the identification rates between the 2 groups was statistically significant (P = 0.038). Pathological results revealed 3 accidental PGs resection occurred in the CN group, whereas 9 accidental PGs removal occurred in the control group. The difference was statistically significant (P = 0.046). Moreover, the incidence of the patients with hypoparathyroidism was statistically significant between the 2 groups (36.6% in CN group vs 53.7% in control group, P = 0.043) at day 1, but not at day 7 (P = 0.424).CN may have a potential in protecting PGs clinically.

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Colorectal cancer lymph node staining by activated carbon nanoparticles suspensionin vivoor methylene bluein vitro

Abstract: Both activated carbon nanoparticles suspension in vivo and methylene blue in vitro can be used as tracers to increase the detected number of lymph nodes in colorectal cancer.

Cited by 54 publications

References 37 publications

Effect of activated carbon nanoparticles on lymph node harvest in patients with colorectal cancer

Effect of activated carbon nanoparticles on lymph node harvest in patients with colorectal cancer

Carbon nanoparticle–guided central lymph node dissection in clinically node‐negative patients with papillary thyroid carcinoma

Potential role of carbon nanoparticles in protection of parathyroid glands in patients with papillary thyroid cancer

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