Colorectal cancer incidence and mortality: the current status, temporal trends and their attributable risk factors in 60 countries in 2000–2019

Abstract

Background: Globally, colorectal cancer (CRC) imposes a substantial burden on healthcare systems and confers considerable medical expenditures. We aimed to evaluate the global and regional burden in epidemiological trends and factors associated with the incidence and mortality of CRC. Methods: We used data from the GLOBOCAN database to estimate CRC incidence and mortality worldwide in 2020 and their association with the human development index (HDI). Trends of age-standardized rates of incidence and mortality in 60 countries (2000–2019) were evaluated by Joinpoint regression analysis using data of Global Burden of Disease 2019. The association between exposure to country-level lifestyle, metabolic and socioeconomic factors obtained from the World Health Organization Global Health Observatory and World Bank DataBank data and CRC incidence and mortality was determined by multivariable linear regression. Results: CRC incidence and mortality varied greatly in the 60 selected countries, and much higher incidence and mortality were observed in countries with higher HDIs, and vice versa. From 2000 to 2019, significant increases of incidence and mortality were observed for 33 countries (average annual percent changes [AAPCs], 0.24–3.82) and 18 countries (AAPCs, 0.41–2.22), respectively. A stronger increase in incidence was observed among males (AAPCs, 0.36–4.54) and individuals <50 years (AAPCs, 0.56–3.86). Notably, 15 countries showed significant decreases in both incidence (AAPCs, −0.24 to −2.19) and mortality (AAPCs, −0.84 to −2.74). A significant increase of incidence among individuals <50 years was observed in 30 countries (AAPCs, 0.28–3.62). Countries with higher incidence were more likely to have a higher prevalence of alcohol drinking, higher level of cholesterol level, higher level of unemployment, and a poorer healthcare system. Conclusions: Some high-HDI countries showed decreasing trends in CRC incidence and mortality, whereas developing countries that previously had low disease burden showed significantly increased incidence and mortality trends, especially in males and populations ≥50 years, which require targeted preventive health programs.

Prostate Cancer Incidence and Mortality: Global Status and Temporal Trends in 89 Countries From 2000 to 2019

“…A country was rated as a 3 star when the percent well-certified data ≥35%, a 4 star for the percent well-certified data ≥65%, and a 5 star for the percent well-certified data ≥85%. To assure the stability and reliability of the temporal trends as previous studies ( 38 , 39 ), we only analyzed the data for countries with a 3-star or higher level in the GBD dataset, and a total of 89 countries were included in the final analysis ( Table 1 ).…”

Analysis of Interventional Application Effect of Ultrasound-Guided QLB and TAPB in the Treatment and Analgesia of Patients Undergoing Laparoscopic Colorectal Surgery

“…Colorectal cancer is a common malignant tumor of the digestive system, and the incidence of cancer diseases is on the rise. With the continuous improvement of people's living standards, the incidence of this disease is also gradually increasing [ 1 ]. At the present stage, the clinical treatment of colorectal cancer is mainly through laparoscopic microincision, which has become a widely used surgical method in clinical practice due to its advantages of small wound, less intraoperative blood loss, and fast recovery [ 2 , 3 ].…”

Cost‐effectiveness of risk‐tailored screening strategy for colorectal cancer: A systematic review

“…Colorectal cancer (CRC) is one of the most common diagnosed cancer in the world, with 1 880 725 new cases and 915 880 death cases occurring in 2020 1 . For many countries in Asia, Eastern Europe, and South America, the CRC burden have been increasing in the past decades 2 . Because of relatively definite natural history from adenoma to cancer and its long preclinical phase for early detection, screening has been demonstrated effective in reducing the incidence and mortality of CRC 3…”

“…1 For many countries in Asia, Eastern Europe, and South America, the CRC burden have been increasing in the past decades. 2 Because of relatively definite natural history from adenoma to cancer and its long preclinical phase for early detection, screening has been demonstrated effective in reducing the incidence and mortality of CRC. 3 Quite a few countries have implemented population-based or opportunistic CRC screening programs for several decades, and main screening techniques included colonoscopy, sigmoidoscopy, fecal immunochemical test (FIT) and guaiac-based fecal occult blood test (FOBT).…”