Colorectal cancer in younger adults from a Bi‐National Colorectal Cancer Audit registry

Kong, Joseph; Su, Wai Kin; Ng, Chu Woon; Guerra, Glen R; Chakraborty, J.; Lutton, Nicholas; Morris, Bradley J.; Gourlas, Peter

doi:10.1111/ans.16250

Cited by 4 publications

(3 citation statements)

References 17 publications

(32 reference statements)

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“…There is a growing concern worldwide about the increasing incidence of CRC in younger adults (below 50 years old). This trend has raised clinical concerns that younger adults may present with more advanced disease, leading to a poorer prognosis compared to older cohorts due to a lack of screening (15,16). Recent studies have reported that a younger age at diagnosis and receiving systematic therapies could potentially result in longer OS and DSS for CRC patients (17).…”

Section: Discussionmentioning

confidence: 99%

Urban vs. rural: colorectal cancer survival and prognostic disparities from 2000 to 2019

Fu,

Pan,

Cai

et al. 2024

Front. Public Health

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This study aimed to analyze the differences in colorectal cancer (CRC) survival between urban and rural areas over the past 20 years, as well as investigate potential prognostic factors for CRC survival in both populations. Using registry data from Surveillance, Epidemiology, and End Results (SEER) from 2000 to 2019, 463,827 CRC cases were identified, with 85.8% in urban and 14.2% in rural areas. The mortality of CRC surpassed its survival rate by the sixth year after diagnosis in urban areas and the fifth year in rural areas. Furthermore, the 5-year overall survival (OS) of CRC increased by 2.9–4.3 percentage points in urban and 0.6–1.5 percentage points in rural areas over the past two decades. Multivariable Cox regression models identified independent prognostic factors for OS and disease-specific survival (DSS) of CRC in urban and rural areas, including age over 40, Black ethnicity, and tumor size greater than 5 cm. In addition, household income below $75,000 was found to be an independent prognostic factor for OS and DSS of CRC in urban areas, while income below $55,000 was a significant factor for rural areas. In conclusion, this study found a notable difference in CRC survival between rural and urban areas. Independent prognostic factors shared among both rural and urban areas include age, tumor size, and race, while household income seem to be area-specific predictive variables. Collaboration between healthcare providers, patients, and communities to improve awareness and early detection of CRC may help to further advance survival rates.

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Section: Discussionmentioning

confidence: 99%

Urban vs. rural: colorectal cancer survival and prognostic disparities from 2000 to 2019

Fu,

Pan,

Cai

et al. 2024

Front. Public Health

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“…However, unregulated inflammation can cause significant damage to the body, and a chronic inflammatory state impedes immune infiltration and increases angiogenesis, providing an ideal environment for the growth and reproduction of cancer cells and promoting the generation and spread of cancerous lesions. Relapsing tumors aggravate the inflammatory response in the body and form a negative feedback loop that increases the risk of postoperative relapse in patients[ 31 - 33 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of multiple risk factors for colorectal cancer relapse after laparoscopic radical resection

Luo,

He,

Luo

et al. 2023

World J Gastrointest Surg

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Postcholecystectomy bile duct injury (BDI) remains a devastating iatrogenic complication that adversely impacts the quality of life with high healthcare costs. Despite a decrease in the incidence of laparoscopic cholecystectomy-related BDI, the absolute number remains high as cholecystectomy is a commonly performed surgical procedure. Open Roux-en-Y hepaticojejunostomy with meticulous surgical technique remains the gold standard surgical procedure with excellent long-term results in most patients. As with many hepatobiliary disorders, a minimally invasive approach has been recently explored to minimize access-related complications and improve postoperative recovery. Since patients with gallstone disease are often admitted for a minimally invasive cholecystectomy, laparoscopic and robotic approaches for repairing postcholecystectomy biliary stricture are attractive. While recent series have shown the feasibility and safety of minimally invasive post-cholecystectomy biliary stricture management, most are retrospective analyses with small sample sizes. Also, long-term follow-up is available only in a limited number of studies. The principles and technique of minimally invasive repair resemble open repair except for the extent of adhesiolysis and the suturing technique with continuous sutures commonly used in minimally invasive approaches. The robotic approach overcomes key limitations of laparoscopic surgery and has the potential to become the preferred minimally invasive approach for the repair of postcholecystectomy biliary stricture. Despite increasing use, lack of prospective studies and selection bias with available evidence precludes definitive conclusions regarding minimally invasive surgery for managing postcholecystectomy biliary stricture. High-volume prospective studies are required to confirm the initial promising outcomes with minimally invasive surgery.

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“…The incidence of CRC in younger adults (<50 years old) is rising worldwide, which has been at a rate of 1% per annum since mid-1980s and nearly 2 times as high as that in older populations. 1 This trend raised clinical concerns that younger adults may have more advanced disease leading to poorer prognosis compared to their older cohort due to lack of screening. 2 The distribution of CRC is significantly different in regions all over the world.…”

Section: Introductionmentioning

confidence: 99%

Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

Sun¹,

Liu²,

Huang³

et al. 2021

IJGM

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Purpose This study aimed to analyze incidence and mortality trends and risk factors of colorectal cancer (CRC) in China during 2005–2015. Materials and Methods Patient cases were extracted from the Chinese Cancer Registry Annual Report. Joinpoint regression and Poisson regression were applied to analyze incidence and mortality trends and risk factors of CRC. Age-period-cohort model was used to evaluate the age, period and cohort effects on CRC. Results The standardized incidence and mortality rate of CRC in China showed a decreasing trend during 2005–2015. The incidence in men (APC=−1.22%, P<0.05) decreased from 2005 to 2015 and decreased in women (APC =−3.55%, P<0.05) from 2005 to 2013, then increased during 2013–2015 (APC =18.77%, P<0.05). The incidence and mortality in urban areas were higher than those in rural (The incidence in urban: APC =−0.97%, P<0.05; rural: APC =1.94%, P<0.05; the mortality in urban: APC =−0.67%, P<0.05; rural: APC =0.29%). For age-specific rates, the incidence begins to increase significantly at 40–45 age group and reached a peak at 75; the mortality increased significantly at 45–50. The age effect increased with age in general. The 1920 birth cohort had the highest risk of colorectal cancer incidence and death. Poisson regression showed region, gender and age were independent risk factors of CRC. Conclusion The age-adjusted standardized incidence rate (ASIR) and age-adjusted standardized mortality rate (ASMR) of CRC in China during 2005–2015 were decreasing. A great concern on men, rural areas and people aged over 75 should be aroused to prevent colorectal cancer.

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Colorectal cancer in younger adults from a Bi‐National Colorectal Cancer Audit registry

Cited by 4 publications

References 17 publications

Urban vs. rural: colorectal cancer survival and prognostic disparities from 2000 to 2019

Urban vs. rural: colorectal cancer survival and prognostic disparities from 2000 to 2019

Identification of multiple risk factors for colorectal cancer relapse after laparoscopic radical resection

Colorectal Cancer Incidence and Mortality Trends and Analysis of Risk Factors in China from 2005 to 2015

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