Colorectal cancer in the young, many questions, few answers

Deen, K.I.; Silva, Hiroshi; Deen, Raeed; Chandrasinghe, Pramodh

doi:10.4251/wjgo.v8.i6.481

Cited by 60 publications

(47 citation statements)

References 67 publications

(91 reference statements)

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“…The distribution of incidence by age is important because it guides the screening strategy and particularly the lower limit of age to be targeted by this intervention. Indeed, it is clear that for ages with low specific incidence rates (young adult) with generally poor prognosis and sometimes familial or genetic characteristics are not suitable for mass screening (the cost-effectiveness of screening would be reduced) [13,[56][57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

Khiari

Hsaïri

2018

Colorect. Cancer

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. The aim of this study was to determine CRC incidence and to describe clinicopathological features in north Tunisia for the period 2007–2009. The North Tunisia Cancer Registry was the source of data for the identification of patients. The age-standardized incidence rates (ASRs) were respectively 13.6 cases (7.5/100,000 for colon cancer and 6.2 for rectal cancer) and 11.1 cases (6.5/100,000 for colon cancer and 4.4 for rectal cancer) per 100,000 among male and female. The ASR varied widely by regions in northern Tunisia. The most common site in colon cancer was the distal colon comparing to the proximal one (49.0 and 29.9% respectively). Adenocarcinoma was the most common histological type. CRC screening should be strengthened in Tunisia to achieve a reduction of CRC incidence and mortality.

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Section: Discussionmentioning

confidence: 99%

Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

Khiari

Hsaïri

2018

Colorect. Cancer

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“…However, the trends of CRC in East Asian countries are quite different. Young-age CRC is common in these countries 5. Different studies conducted in Pakistan had also shown the average age of CRC to be 40 to 45 years 67…”

Section: Introductionmentioning

confidence: 99%

Red flag symptoms: detailed account of clinicopathological features in young-onset colorectal cancer

2017

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Background/AimsColorectal cancer has long been considered disease of the West, typically occurring in old age; however, the incidence is rising in Asia. The pattern of disease is quite different in Asia, occurring at a younger age and at an advanced stage. Recognition of disease at an early stage is still a challenge for physicians. Few data are available regarding young-onset colorectal cancer in Pakistan. We conducted this study to fill this gap and provide deeper insight into clinical symptoms and histopathological features of young-onset colorectal cancer.MethodsWe collected data regarding clinical features by directly interviewing patients and obtaining histopathological data from hospital records. Patients aged less than 50 years were included in the study. Statistical analysis was performed using IBM SPSS version 20.0.ResultsResults in 105 patients showed mean age at diagnosis was 35.90±9.39, with male predominance; the majority of patients had no family history of colorectal cancer. Most patients had left-sided tumors with advance stage and intermediate grade (grade 2). Mucinous histology was common. Rectal bleeding was the first symptom for left-sided tumors, whereas most of the right-sided lesions presented with sudden obstruction.ConclusionsPainless rectal bleeding in the early thirties should alert physicians to advise appropriate investigation, as the majority of young-onset colorectal cancer patients develop painless bleeding 2 to 3 years before appearance of other symptoms.

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“…Antiproliferative Activity. Breast and colon cancer are the most common cancer worldwide [46,47]. According to the National Cancer Registry 2007 of Malaysia, breast and colorectal cancer also are the most common cancer in Malaysia [48].…”

Section: Antiplasmodial Activitymentioning

confidence: 99%

New Silver Complexes with Mixed Thiazolidine and Phosphine Ligands as Highly Potent Antimalarial and Anticancer Agents

Sofyan

Nordin

Razak

et al. 2018

Journal of Chemistry

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Five silver(I) complexes containing a mixed ligand system of phosphine and thiazolidine were successfully synthesized. e structural information of the complexes was assembled using various spectroscopic techniques such as CHN elemental analysis, Fourier transformed infrared (FTIR), 1 H, 13 C, and 31 P{ 1 H} NMR spectroscopy, and thermogravimetric analysis (TGA). A bidentate phosphine ligand acted as a chelating agent which bond to the silver in 1 : 2 molar ratios. Meanwhile, thiazolidine was attached to the silver in a 1 : 1 molar ratio. e antiplasmodial properties of all synthesized complexes were investigated on chloroquine-resistant P. falciparum parasite via HRP2 assays and cytotoxicity tests on Vero cells. Of all the synthesized complexes, complex 2 showed the highest SI value (more than 12.4) followed by complex 5 (6.6). e potent properties of compounds 2 and 5 were also noted in the in vitro antiproliferative assays involving MDA-MB-231 and MCF-7 breast cancer cell lines as well as HT-29 colon cancer cell line. Complex 2 was selective for MDA-MB-231 cells (GI 50 � 1.9 ± 0.3 µM), while complex 5 acted predominantly on breast carcinoma cells (GI 50 MDA-MB-231 � 4.7 ± 1.1 µM; MCF-7 � 2.9 ± 0.9 µM) instead of colon carcinoma (HT-29) cells (GI 50 � 15.1 ± 1.9 µM).

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Colorectal cancer in the young, many questions, few answers

Cited by 60 publications

References 67 publications

Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

Red flag symptoms: detailed account of clinicopathological features in young-onset colorectal cancer

New Silver Complexes with Mixed Thiazolidine and Phosphine Ligands as Highly Potent Antimalarial and Anticancer Agents

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