Colorectal cancer in the young: trends, characteristics and outcome

Abstract

The frequency of CRC in young patients increased significantly. Vascular invasion is the single most important prognostic factor in young CRC. Along with vascular invasion, high proportion of T4 status in young patients increases the chances of recurrence and negates any survival advantage in young patients.

Rising Incidence of Rectal Carcinoma in the Young Age “Is it A Concern?" An Indian Perspective

“…In our data, 70.7% of the young had stage III disease at diagnosis, while only 48.2% of their older counterparts presented with this stage. This figure is much higher than in many other foreign studies ( Figure 1) [18,19].…”

Comparable survival for young rectal cancer patients, despite unfavourable morphology and more advanced-stage disease

“…Furthermore, these differences could be due to the large number of missing values in our study and the fact that interpretation can differ between Dutch and American pathologists. Recent data on the incidence rates of mucinous tumours in young patients are only available from small studies, mainly involving colorectal cancer patients; in these studies, the reported rate of mucinous tumours varied widely, from 6.1% to 32% [8,10,21]. Older studies recorded an average rate of mucinous tumours in young colorectal patients of 21% [27,28].…”

“…Young patients with rectal cancer more often present with advanced-stage disease and unfavourable tumour morphology compared with middle-aged patients [6][7][8][9][10]. Studies focusing on survival in young rectal cancer patients have shown at least equal or better outcomes compared with older patients [9,10].…”

“…More recent studies have been smaller and included patients with both colon and rectal cancer, leading to uncertainty about the possible effects of adverse tumour morphology and advanced-stage disease on survival in young rectal cancer patients [6,8,10,13,14].…”

Colorectal Cancer in the Kingdom of Saudi Arabia: Need for Screening

“…Whether or not we should start screening at a lower age is another question, which has been repeatedly brought up in other countries with similar epidemiological observation (Davis, 2011;Ganapathi et al 2011). Proper identification of cases of Lynch syndrome and other familial causes of CRC is necessary, as this group should be managed differently.…”