Colorectal cancer in Crohn’s disease: a series of 6 cases

Abstract

Background Colorectal cancer (CRC) is the most malignant complication in patients with Crohn’s disease (CD). We report 6 cases of CD-related CRC treated surgically at our hospital. Case presentation From 2010 to 2016, six CD patients were diagnosed with CRC. All patients were diagnosed with CD at < 25 years old, and the interval from onset of CD to diagnosis of CRC was > 10 years (range, 15–42 years) in all patients. The histological type of cancer was mucinous carcinoma in two cases, well-differentiated tubular adenocarcinoma in two cases, and moderately differentiated tubular adenocarcinoma in two cases. CRC was detected by screening colonoscopy in three cases (50%), and from clinical symptoms in the remaining three cases (50%). Two cases underwent colonoscopy within 2 months after symptom onset, detecting CRC in the relatively early stage. However, one case was diagnosed with advanced-stage CRC by endoscopy 1 year after symptom onset, and experienced poor prognosis. Conclusions Regular surveillance colonoscopy is needed to detect early-stage CRC in CD patients. Clear surveillance methods need to be established based on evidence.

Perirectal Mucinous Adenocarcinoma After Subtotal-Colectomy for Crohn’s Disease: A Case Report

“…As expected, risk factors for CRC development in CD include younger age at CD diagnosis and disease duration > 10 years. While non-mucinous adenocarcinoma is still the most prevalent CRC identified in patients with Crohn’s disease, there is a higher prevalence of the mucinous subtype in patients with Crohn's disease as compared to the general population [ 8 ] Compared to non-mucinous adenocarcinoma, patients with the mucinous subtype are usually diagnosed at a more advanced stage and have a poorer response to chemotherapies. A recent population-based study reported an approximately 93% 5-year survival rate for patients with localized disease [ 9 ].…”

Dextran-Coated Iron Oxide Nanoparticles Loaded with 5-Fluorouracil for Drug-Delivery Applications

“…Colorectal cancer (CRC) is the third most prevalent malignant tumor and the second most prevalent cause of cancer death in the world. Generally, CRC occurs in people older than 50 [ 1 ], more in men than in women [ 2 ], and in those who have a family history of CRC [ 3 ] as well as inflammatory bowel disease [ 4 ]. Overweight or obesity [ 5 ], low physical exercise [ 6 ], excess consumption of red meat and processed meat, diets low in fiber, calcium, milk, and whole grains [ 7 ], smoking [ 8 ], and alcohol use [ 9 ] are risk factors for this pathology.…”