Colorectal Cancer: Epidemiology, Disease Mechanisms and Interventions to Reduce Onset and Mortality

Aran, Veronica; Victorino, Ana Paula; Thuler, Luiz Cláudio Santos; Ferreira, Carlos Gil

doi:10.1016/j.clcc.2016.02.008

Cited by 281 publications

(228 citation statements)

References 109 publications

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“…Reproductive factors and the use of oral contraceptives are the main risk factors of breast cancer (24), and they vary significantly across China owing to the contradiction between traditional concept and westernized concept alongside with the economic development. Colorectal cancer is also well-known for its relation with a westernized lifestyle, obesity and other factors that are easy to find in an affluent society (25).…”

Section: Discussionmentioning

confidence: 99%

Comparison of cancer incidence and mortality in three GDP per capita levels in China, 2013

Yang

Zheng

Zhang

et al. 2017

Chinese Journal of Cancer Research

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Objective: In this research, the patterns of cancer incidence and mortality in areas with different gross domestic product per capita (GDPPC) levels in China were explored, using data from population-based cancer registries in 2013, collected by the National Central Cancer Registry (NCCR).Methods: Data from 255 cancer registries were qualified and included in this analysis. Based on the GDPPC data of 2014, cities/counties were divided into 3 levels: high-, middle-and low-GDPPC areas, with 40,000 and 80,000 RMB per year as cut points. We calculated cancer incidences and mortalities in these three levels, stratified by gender and age group. The national population of the Fifth Census in 2000 and Segi's population were applied for age-standardized rates. Results:The crude incidence and mortality rates as well as age-standardized incidence rate (ASIR) showed positive associations with GDPPC level. The age-standardized mortality rate (ASMR) nevertheless showed a negative association with GDPPC level. The ASMR in high-, middle-and low-GDPPC areas was 103.12/100,000, 112.49/100,000 and 117.43/100,000, respectively. Lung cancer was by far the most common cancer in all three GDPPC levels. It was also the leading cause of cancer death, regardless of gender and GDPPC level. Negative associations with GDPPC level were found for the ASIRs of lung, stomach, esophageal and liver cancer, whereas colorectal and breast cancer showed positive associations. Except for breast cancer, the ASMRs of the other five cancers were always higher in middle-and low-GDPPC areas than in high-GDPPC areas. Conclusions:The economic development is one of the main factors of the heavy cancer burden on Chinese population. It would be reasonable to implement cancer control strategies referring to the local GDPPC level.

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Section: Discussionmentioning

confidence: 99%

Comparison of cancer incidence and mortality in three GDP per capita levels in China, 2013

Yang

Zheng

Zhang

et al. 2017

Chinese Journal of Cancer Research

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“…In previous years, scientists have concentrated their attention on the mechanisms behind these factors and the approaches of enhancing disease prevention and treatment. Enhancing the awareness of the population with respect to the advantages of a healthy lifestyle, comprising a balanced diet accompanying with exercise, could totally diminish CRC risk [2].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Awareness Levels toward Colorectal Cancer Early Detection and Prevention in Saudi Arabia

Ahmed¹

2017

GHOA

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“…Although, there are hereditary and non-hereditary CRC types, but the majority is non-hereditary and commonly caused by somatic mutations in response to environmental factors. In the past few years, scientists have concentrated their thoughtfulness on the mechanisms behind these factors and the methods of enhancing disease prevention and treatment [3]. CRC is not a homogenous disease, but can be classified into different subtypes, which are characterized by specific molecular and morphological alterations [4].…”

Section: Introductionmentioning

confidence: 99%

Histopathological Pattern of Colorectal Cancer in Relation to Age and Gender in Northern Saudi Arabia

Ahmed¹,

Alawad²,

Alharbi³

et al. 2017

JCPCR

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Colorectal Cancer: Epidemiology, Disease Mechanisms and Interventions to Reduce Onset and Mortality

Cited by 281 publications

References 109 publications

Comparison of cancer incidence and mortality in three GDP per capita levels in China, 2013

Comparison of cancer incidence and mortality in three GDP per capita levels in China, 2013

Assessment of Awareness Levels toward Colorectal Cancer Early Detection and Prevention in Saudi Arabia

Histopathological Pattern of Colorectal Cancer in Relation to Age and Gender in Northern Saudi Arabia

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